An element of thought: phosphorus and mental philosophy in the nineteenth century

Georges Cabanis (1757-1808), through his writings on the relation of the physical and moral, or psychological, aspects of man, left a legacy that made the study of mental activity a part of physiology. His views on the importance of phosphorus to the function of the brain thrust that element into a prominent stream of research that involved many investigators in several countries. Although that particular stream eventually dried up, its influence remained: by the beginning of the twentieth century basic medical science had become well set on studies of the mind-body relationship.     

Instrument transfer as knowledge transfer in neurophysiology: François Magendie's (1783-1855) early attempts to measure cerebrospinal fluid pressure

Fran?ois Magendie's (1783-1855) experimental model for measuring blood pressure in animals, which he developed in 1838, had a major impact on French physiology in the nineteenth century, especially upon Etienne-Jules Marey (1830-1904) in Paris. In due course it was also adopted by other European investigators, such as the Leipzig physiologist Carl Ludwig (1816-1895), and by clinicians who developed it into a major measuring tool. Historians of science, however, have paid hardly any attention to Magendie's further laboratory investigations conducted with the assistance of Jean-Louis Marie Poiseuille's (1799-1869) sphygmomètre (blood pressure meter). After having used the apparatus to conduct his experiments on a variety of blood vessels, Magendie also applied the sphygmomètre in 1840 to the ventricular system of the brain in order to measure cerebrospinal fluid (CSF) pressure. But the scope of this new procedure had yet to be defined: the new measuring device invited many speculative interpretations about the meaning of CSF flow for the physiology of the ventricular system in healthy and diseased brain function. As such, Magendie's experiments produced phenomena in very heterogeneous knowledge areas, and CSF measurement was situated at the interface of quite disparate investigative spaces regarding the structure and function of the brain. In his textbook Le?ons sur les Fonctions et les Maladies du Système Nerveux (Lectures on the Functions and Diseases of the Nervous System), Magendie described extending application of the measuring "apparatus of Poiseuille" from blood vessels to parts of the brain. The instrument thus became something of a liquidodynamomètre (liquor dynamometer), that paved the way for later applications, including (after 1896) diagnostic intracranial pressure (ICP) measurement by Theodor Kocher (1841-1917) and Harvey Cushing (1869-1939). The current paper focuses on the experimental contingencies that prompted the instrument transfer in Magendie's laboratory and opened up new epistemological perspectives for research in neurophysiology.     

The search for a precise method of measurement in psychical experiments

Presents three brief case studies to show how cognition and psychic activity were explored as energetic and economic transactions in a variety of experimental settings. First, in the 1870's German psychiatrist Emil Kraepelin began a search for an objective measurement of cognitive performance in which he engaged for several decades. His investigations resulted in a graphic representation of cognitive efficiency, the Arbeitscurve, delineating numbers of additions per time interval in close resemblance to representations of machine efficiency. Second, at the turn of the century American nutrition scientist and agronomist Wilbur Olin Atwater convinced himself in a series of precision measurements that the human motor was a perfectly closed input-output system and that any mental surplus in the form of cognitive energy transformation did not count as contradictions to the principle of the conservation of energy. Third, at the beginning of the 20th century and on the basis of Atwater's results, German psychiatrist Hans Berger stipulated a special form of psychic energy for mediating between the principle of the conservation of energy and mental causality. Berger attempted to quantify psychic energy as one factor of brain metabolism. In the three cases of precision investigations into psychic life presented here, the experimental space of psychophysiology turned mental activity into a form of machine-like behavior.     

Albert the Great's interpretation of neuropsychiatric symptoms in the context of scholastic psychology and physiology

Albert the Great (ca. 1193-1280) serves as an example to show how the Latin West successfully integrated Greco-Arabian psychology with Galenic physiology. He divised a model of perceptive, cognitive and mnestic powers located in different areas of the "brain cells" and interacting with the immaterial and man-specific intellect. He managed to describe anmesis, epileptic seizures and psychotic states as results of disturbed brain fuction. Finally, further aspects of Scholastic theorizing on mental disorders are discussed.     

An Element of Thought: Phosphorus and Mental Philosophy in the Nineteenth Century

Georges Cabanis (17571808), through his writings on the relation of the physical and moral, or psychological, aspects of man, left a legacy that made the study of mental activity a part of physiology. His views on the importance of phosphorus to the function of the brain thrust that element into a prominent stream of research that involved many investigators in several countries. Although that particular stream eventually dried up, its influence remained: by the beginning of the twentieth century basic medical science had become well set on studies of the mind-body relationship.     

Historical aspects of cerebrotendinous xanthomatosis (CTX)

Thomas Willis made numerous contributions to the neurosciences that were broad in scope. In an age of scientific breakthroughs and intellectual revolutions, Willis bestowed upon medical research the clinical rigor that set the stage for subsequent medical breakthroughs. In Cerebri Anatome, Willis introduced a measure of empiricism hitherto unknown in medieval times. By coupling the delineation of brain and neural anatomy with functional studies, Willis brought the science of clinical neurology into fruition. Psychiatry, too, benefited from Willis' elucidation of mental illness and intellectual disability, and modern behavioral psychologists claim Willis as one their early, most ardent champions.     

Serendipity and the cerebral localization of pleasure

Most accounts of the discovery of "pleasure" circuits in the brain begin with the observation by James Olds and Peter Milner in 1953 that electrical brain stimulation can condition operant responses in rats. Less well-known, pleasurable brain stimulation was previously observed in schizophrenic patients by Robert Heath. However, Heath failed to recognize the significance of this observation, at least in part, because of preconceived notions he held about the etiology of schizophrenia. This episode in the history of neuroscience illustrates the importance of sagacity in serendipitous scientific discoveries. It also shows that "mental preparedness" can be an obstacle to progress.     

Magendie and the chemists: the earliest chemical analyses of the cerebrospinal fluid

Having described the spinal fluid, Fran?ois Magendie (1783-1855) called upon a number of chemists in Paris to analyze the material, in the effort to decide if it was a special secretion of the nervous system or simply a filtrate of the blood. J.L. Lassaigne (1800-1859) and J.P. Couerbe (1805-1867) responded. Their results, and those of some earlier investigators, are described. In the ensuing years of the nineteenth century, other investigators similarly conducted analyses of spinal fluid, but these were usually of single constituents in poorly defined diagnostic conditions. In 1909-1912, William Mestrezat (1883-1928) took advantage of the recently introduced technique of lumbar puncture, which by now had become hospital routine, and introduced the modern era of systematic analysis of many components of the spinal fluid, correlated with specific disease states.     

From Zero-Sum to Value-Added Strategies: The Emergence of Knowledge-Based Industrial Policy in the States of the United States

State science policy is industrial policy, shaped by local research and industrial strengths or, conversely, lack of same. States with research strengths relevant to local declining industries attempt to link them in an effort to revive the latter; states lacking research strengths attempt to develop them, especially in areas relevant to local natural resources that have the potential to be the basis of new high-tech industries. Such knowledge-based industrial policies supplement, even if they do not replace, traditional strategies focused upon: (a) creating economic activity based upon natural resources such as harbors or mineral deposits, (b) improving the business climate by lowering taxes, or (c) attracting industry to relocate by offering subsidies. The role of the federal government in science-based industrial policy is still controversial even as it is widely accepted in the states as part of traditional responsibilities for their citizen's economic welfare.     

空心村村民居住生活空间特征及其优化重构——对河南邓州市8个村庄的调查

在空心村整治过程中,地方政府普遍重视通过土地整理和迁村并点实现用地集约,而忽视对村庄内部村民居住生活空间的优化。本文以邓州市桑庄镇8个村作为调研区域,对当地村民进行问卷调查和深度访谈,归纳出空心村背景下乡村居住生活空间的形态变化和利用模式,分析其反映出的乡村生活中的矛盾与问题,并在此基础上提出对乡村居住生活空间的重构思路,为空心村整治过程中乡村社区的重建与优化提供参考。     

Johann August Philipp Gesner (1738-1801). A review of his essay "The language amnesia" in the bicentennial anniversary of his death

On the 200th anniversary of Johann August Philipp Gesner's death, this paper summarizes and discusses a paper on language amnesia published in 1770. The author had clear knowledge of selective mental impairments resulting from brain diseases, and of separate mental representations for words and their underlying concepts. However, to explain the language impairment, Gesner suggested that it would not be caused by focal damage to a specific anatomic and functional unit of the mind, but is the consequence of a general sluggishness of the mental processes.     

Johann August Philipp Gesner (1738–1801). A Review of His Essay “The Language Amnesia” in The Bicentennial Anniversary of His Death

On the 200th anniversary of Johann August Philipp Gesner's death, this paper summarizes and discusses a paper on language amnesia published in 1770. The author had clear knowledge of selective mental impairments resulting from brain diseases, and of separate mental representations for words and their underlying concepts. However, to explain the language impairment, Gesner suggested that it would not be caused by focal damage to a specific anatomic and functional unit of the mind, but is the consequence of a general sluggishness of the mental processes.     

Light and enlightenment: Cabanis, ideology, and the role of phosphorus in the brain

When Georges Cabanis presented his views to the National Institute of France in 1797 on the physiological basis of human psychology, he introduced the concept that phosphorus was of special importance in the workings of the brain. The presence of phosphorus in that organ had only recently been described by A F Fourcroy, a finding that impressed Cabanis because of the association of light (phosphorescence) and heat (evolved during oxidation) with the element. Furthermore, he hypothesised that the electrical activity of the brain represented a parallel and interacting system with that of phosphorus. Cabanis was one of the leading exponents of "ideology", the principal school of philosophy at the time of the French Revolution. Ideology promoted the systematisation of knowledge in every sphere--social, scientific and medical, for example-- and Cabanis's views about cerebral phosphorus evolved from those teachings.     

Effects of commune-internal migration in Finland on the spatial distribution of population and on dwelling house utilization

"The article is based on a programme of research which has been pursued for some years with the purpose of describing the extent and spatial orientation of commune-internal migration [in Finland], a topic about which very little has previously been known, relating this form of migration to total population movement and to dwelling house requirements and utilization. The analysis yields information on the dynamics of population changes occurring in areas on the margins of permanent settlement, while at the same time taking into consideration the effects of regional and in particular housing policy decisions upon the spatial distribution of population."     

The loyal dissident: N.A. Bernstein and the double-edged sword of Stalinism

Nikolai Aleksandrovich Bernstein (1896-1966) studied movement in order to understand the brain. Contra Pavlov, he saw movements (thus, the brain) as coordinated. For Bernstein, the cortex was a stochastic device; the more cortexes an animal species has, the more variable its actions will be. Actions are planned with a stochastic "model of the future," and relevance is established through blind mathematical search. In the 1950 neoPavlovian affair, he came under strong attack and had to stop experimenting. It is argued that the consistency of his work derived both from both dialectical materialism and the relentless attacks of the neoPavlovians.     

Recording the brain at work: the visible, the readable, and the invisible in electroencephalography

The electroencephalogram (EEG), the graphic recording of the electric activity of the human brain, kindled far-reaching speculations about the imminent deciphering of mind and brain in the 1930s. Regardless of the thousands of neurons in the human cortex, recording from a person at rest produced a surprisingly regular line oscillating at 10 per second that disappeared at the moment of mental activity. With ever more groups specializing in electroencephalography, however, the deciphering of mind and brain did not materialize but moved further away in the information produced. In the various approaches employed in EEG research, such as the analysis of the graphic code, the search for pathognomic patterns or the imaging of cognitive processing, visualization guided research as well as theorizing, its productivity continued to keep the epistemological question open.     

Obsessive Compulsive Disorder (OCD): The ritual moment of social death

This article is an ethnographic study of individuals self‐diagnosed with Obsessive Compulsive Disorder (OCD) in Liverpool, UK. While much research on OCD has concentrated upon superstitious belief, psychosis and anxiety provoking disorder, the article focuses upon the relationship between the familiar and the strange in ordinary life, the ‘disquieting familiar’, captured by the Freudian idea of the uncanny. It investigates how misfortune, as opposed to psychological neurosis, becomes attached to mass‐produced objects and routines – the obsessive touching of kitchen taps, the compulsive checking of bank cards – and how repetitive rituals enacted by individuals are revealing of the effort to prevent the emergence of apprehension concealed in everyday habitus and physical, concrete activity.     

Schizophrenia, reification and deadened life

Recent debates concerning the abolition of the schizophrenia label in psychiatry have focused upon problems with the scientific status of the concept. In this article, I argue that rather than attacking schizophrenia for its lack of scientific validity, we should focus on the conceptual history of this label. I reconstruct a specific tradition when exploring the conceptual history of schizophrenia. This is the concern with the question of the sense of life itself, conducted through the confrontation with schizophrenia as a form of life that does not live, or as Robert Jay Lifton termed it "lifeless life" (1979: 222-39). I conclude by arguing that the contemporary attempt to deconstruct or abolish the schizophrenia concept involves a fundamental shift in concern. The attempt both to normalize psychotic experiences, and to conceive them purely in terms of cognitive processes that can be mapped onto brain function, results in a fundamental move away from the attempt to understand the experience of madness.