DISH and the monastic way of life

Diffuse idiopathic skeletal hyperostosis (DISH) is common condition and its prevalence increases markedly with age. This paper describes the pathology and aetiology of the condition; DISH seems to be related to obesity and type II diabetes and is probably a multisystem hormonal disorder. DISH occurs frequently in human skeletal remains, particularly in those recovered from monastic sites. Evidence is presented to confirm this association and the causes are discussed. We also present criteria for the diagnosis of DISH in human remains, which we suggest would permit valid inter‐study comparisons. Copyright © 2001 John Wiley & Sons, Ltd.     

Multicentric osteosarcoma associated with DISH,in a 19th century burial from England

Osteosarcoma is a rare type of malignant neoplasm that is most frequent in adolescents and young adults although it can develop at any age. It can metastasize from a primary site in bone to other bones and soft tissues. Usually the disorder causes a single bone‐forming lesion (unicentric) but some cases have multicentric, bone‐forming lesions. Some of these lesions develop at different sites at different times. In a second variant of multicentric osteosarcoma, synchronous bone‐forming lesions develop at multiple sites. Distinguishing between these two types of multicentric osteosarcoma is challenging in a clinical context and the criteria for doing so are unlikely to be met in an archaeological burial. Wolverhampton burial HB 39 was excavated from an early‐nineteenth century cemetery site in England. It consists of the incomplete skeleton of an adult male of at least 45 years of age with multicentric osteosarcoma. The individual represented by this burial also had diffuse idiopathic skeletal hyperostosis (DISH). Three of the bone‐forming lesions associated with osteosarcoma developed on the bony outgrowths related to DISH. Copyright © 2010 John Wiley & Sons, Ltd.     

Skeletal distribution of degenerative changes in vertebral osteophytosis,vertebral osteoarthritis and DISH

In order to comprehend the condition of vertebral osteophytosis, vertebral osteoarthritis and DISH (diffuse idiopathic skeletal hyperostosis) with respect to diagnosis and aetiology, the vertebral and peripheral (appendicular) frequency and distribution pattern of degenerative joint changes of 176 rather affluent citizens were analysed from the late medieval city of Dordrecht in Holland. Patterns of frequencies with respect to age and sex were found to be similar essentially to those of a present-day Dutch suburban village population. Frequencies for vertebral osteophytosis were twice those for vertebral osteoarthritis, and both increased with age in both sexes. The individual pattern of vertebral osteophytosis and vertebral osteoarthritis seems to indicate that each disorder possesses its own progressive identity. From the distribution pattern and frequency of peripheral osteoarthritis it was concluded, with respect to the vulnerability of developing this complication under physically moderate life conditions, that causal factors for vertebral osteophytosis are less important than those for vertebral osteoarthritis. Osteoarthritis presented itself as a systemic disorder, affecting synovial joints in general. Finally it was appreciated that, with increasing age, bony outgrowths from joint degeneration become anatomically masked by para-articular ossifications from DISH.     

Spinal pathological findings in ancient Egyptians of the Greco‐Roman period living in Bahriyah Oasis

The spine can provide a large amount of information about an individual's physical condition and possible lifestyle through palaeopathological investigations. The aim of this research was to study spinal diseases among Greco‐Roman ancient Egyptians from Bahriyah Oasis, and to compare them with those from Giza of the Old Kingdom. The material used in the study included 809 single vertebrae and 77 adult sacra of ancient Egyptians from the Greco‐Roman period (332–30 BC) that were excavated from Bahriyah Oasis. The spinal elements were examined for pathological conditions, degenerative diseases, trauma, congenital abnormalities, infectious diseases and neoplasms. The most common lesions of the spine were those due to degenerative processes. The articular facets were more affected than the vertebral bodies. Compression fractures of the bodies, mostly due to osteoporosis, were found in 1.44% and 5.07% of thoracic and lumbar vertebrae respectively. The percentage of spina bifida occulta among ancient Egyptians from Bahriyah Oasis was 62.33%, while among those from Giza was only 3.33%. Few cases of lumbar spondylolysis and one case of DISH were recorded. No cases of infectious or neoplastic diseases were found. Copyright © 2008 John Wiley & Sons, Ltd.     

The frequency of os acromiale in the Robert J. Terry Collection

Normal fusion of the acromion process in humans begins at about age 15 and should complete ossification by age 22–25. Os acromiale occurs when fusion of the acromial epiphysis does not follow its normal ossification pattern, resulting in the retention of a separate epiphyseal end to the acromial process. Depending on how the metaphyseal junctures fuse, differential size and shape of the unattached acromial segment is produced. As a result of shoulder anatomy and the mobile epiphysis, os acromiale is associated with shoulder impingement and rotator cuff problems. The purpose of this study is to document the frequency of os acromiale in the Robert J. Terry Collection and gain a perspective on the occurrence of os acromiale in this specific US population. The overall frequency of os acromiale in the sample of 1594 skeletons was 8.34%. This study also evaluates the prevalence of os acromiale between sexes and ancestral groups in the Terry Collection. Significant frequency differences in the expression of os acromiale were found between both ancestry and sex; the black male sample has the highest frequency (12.47%), with a lower occurrence in the black female sample (9.22%). The white sample exhibited observably lower frequencies, with the white males at 6.8%, and white females at 3.2%. Size and shape and side expression (laterality) showed no significant differences between the sexes. However, significant differences in laterality by ancestry were observed; black males exhibited 48.3% bilateral expression, while white males exhibited bilateral expression only 29% of the time and 54.8% had a right lateral expression. Based on the results presented in this study, it is suggested that there is a genetic causation for os acromiale, which may or may not be exacerbated by physical activity. The use of this anomaly as an additional non‐metric feature in inferring familial relationships and personal identification is discussed. Copyright © 2006 John Wiley & Sons, Ltd.     

Implications of Reappraising the Iron‐Deficiency Anemia Hypothesis

In 2009, Walker and colleagues questioned the validity of the iron‐deficiency anemia hypothesis as an explanatory mechanism for the presence of porotic hyperostosis (PH) and cribra orbitalia. They presented evidence demonstrating that iron deficiency inhibits, rather than promotes, marrow hypertrophy and argued a link between both PH and hemolytic or megaloblasic anemias (including vitamin B₁₂ deficiency). This paper suggests that dismissing the iron‐deficiency anemia hypothesis may be premature, but, if dismissed, may result in unforeseen consequences. Vitamin B₁₂ deficiency and iron deficiency often result from similar proximate causes, i.e. lack of animal protein in the diet and sanitation problems that lead to parasitic or diarrheal diseases, thereby promoting nutrient losses. As a result, vitamin B₁₂ deficiency and iron deficiency commonly co‐occur. In individuals with a co‐occurrence of iron deficiency and vitamin B₁₂ deficiency, a possible inhibition of marrow hypertrophy caused by iron deficiency may prevent the development of PH, despite the presence of (vitamin B₁₂) nutritional deficiency. The implications of dismissing the iron‐deficiency anemia hypothesis are that many skeletal populations may exhibit hidden heterogeneity, i.e. individuals who are the most nutritionally stressed, with multiple nutrient deficiencies, would mimic the non‐stressed individuals and neither would show evidence of PH. However, the inclusion of multiple stress indicators and greater understanding of biocultural context in bioarchaeological analyses may mitigate the potential impacts of hidden heterogeneity in the expression of PH. Copyright © 2013 John Wiley & Sons, Ltd.     

Cribra orbitalia: a non‐human primate perspective

Cribra orbitalia, a porous lesion involving the orbital roofs, is one of the most‐studied skeletal pathologies in bioarchaeology, and yet uncertainty still exists regarding its aetiology and significance. In contrast to the hundreds of reports of cribra orbitalia in human skeletal remains, little is known of this condition in non‐human primates. Previously, cribra orbitalia has only been reported in catarrhines, with just two cases in cercopithecoids. To provide a broader, phylogenetic perspective on cribra orbitalia, a sample of primate skeletal material was examined to evaluate the occurrence of this condition. The taxonomically diverse sample consists of 380 non‐hominoid (non‐ape) modern primates from both wild and captive populations. Cribra orbitalia is present in 16 individuals, including cercopithecines, colobines, platyrrhines and a prosimian, substantially expanding the known taxonomic range of this condition. Modern primates—with their varied habitats, diets, levels of parasitism, etc.—provide a set of natural experiments regarding conditions and physiologies which may influence the aetiology and impact of cribra orbitalia. More generally, it is suggested here that studies of non‐human primate skeletal pathologies have the potential for providing significant insight on human paleopathologies. Copyright © 2009 John Wiley & Sons, Ltd.     

Co‐Producing (a Fearful) Anthropocene

The Anthropocene is not amenable to the senses but, like many modern concepts, must be made visible. We explore the ‘Great Acceleration’ imagery as an immutable mobile to explore how this human‐made geological epoch is constituted through the aggregation of disparate elements of extreme complexity. Our analysis explores how disparate issues such as ‘telephone use’ and ‘coastal zone biogeochemistry’ can be associated and enrolled into the same argument. We write as concerned observers, who are concerned with the way that recognition for phenomena is enrolled into a fear‐based narrative. This risks reproducing the governance structures at the heart of the Great Acceleration and, if so, we ask what this might mean. Using fear is a risky strategy that is as likely to lead to relatively poor behaviours as it is to some ‘awakening’. We make this case as a way of contributing to the Anthropocene debate, challenging those promoting the idea to consider the co‐productive relationship between the knowledge they are proposing and the governance that knowledge entails.     

Conservation Narratives in Costa Rica: Conflict and Co‐existence

This article examines narratives about nature conservation in Costa Rica, specifically those related to wildlife and biodiversity, and their evolution with the growth of tourism and bioprospecting industries. It outlines a traditional conservation narrative and two streams of an emerging counter‐narrative, and discusses problems and prospects for each in contemporary Costa Rica. The use of narrative and counter‐narrative follows Roe (1991, 1995), Fairhead and Leach (1995), and Leach and Mearns (1996). The article focuses particularly on the ways in which the narratives are increasingly drawing on, informing, and sometimes conflicting with one another; it is based on the author’s research undertaken in various protected areas in Costa Rica since 1994 and on research published by others.     

Nonparametric Significance Test for Discovery of Network‐Constrained Spatial Co‐Location Patterns

Spatial co‐location patterns are useful for understanding positive spatial interactions among different geographical phenomena. Existing methods for detecting spatial co‐location patterns are mostly developed based on planar space assumption; however, geographical phenomena related to human activities are strongly constrained by road networks. Although these methods can be simply modified to consider the constraints of networks by using the network distance or network partitioning scheme, user‐specified parameters or priori assumptions for determining prevalent co‐location patterns are still subjective. As a result, some co‐location patterns may be wrongly reported or omitted. Therefore, a nonparametric significance test without priori assumptions about the distributions of the spatial features is proposed in this article. Both point‐dependent and location‐dependent network‐constrained summary statistics are first utilized to model the distribution characteristics of the spatial features. Then, by using these summary statistics, a network‐constrained pattern reconstruction method is developed to construct the null model of the test, and the prevalence degree of co‐location patterns is modeled as the significance level. The significance test is evaluated using the facility points‐of‐interest data sets. Experiments and comparisons show that the significance test can effectively detect network‐constrained spatial co‐location patterns with less priori knowledge and outperforms two state‐of‐the‐art methods in excluding spurious patterns.     

Diffuse idiopathic skeletal hyperostosis cases found in Joseon Dynasty Human Sample Collection of Korea

Diffuse idiopathic skeletal hyperostosis (DISH) is a disorder showing hyperostosis of the spinal column and ossification of extraspinal ligaments or tendons. The prevalence of DISH has been found to be higher in historic peoples of the upper‐ and ruling classes, and in fact was closely correlative with nutritional and high‐caloric diets. DISH is also known to be a function of genetic factors; as such, there have been very few cases of DISH found among the specimens of Asian skeletal collections. In our osteoarchaeological study on the Joseon Dynasty Human Sample Collection (JDHSC), we found four DISH instances among the 96 cases (4.17%) we examined. This prevalence is not so different from those discovered in already‐published studies on collections in Europe and other regions. However, as already stated, it must be considered that most of the JDHSC individuals we examined were remains of people from the highest social classes of 16th–18th century Joseon society. Therefore, when collections from medieval European monastic sites, the appropriate control from well‐fed populations, were used for comparison, the prevalence of DISH was found to be far lower among the JDHSC. Reports on DISH from examinations of collections in Asian countries have been spotty, leaving gaps in the social‐strata spectrum. Further researches into the prevalence of DISH among the different social strata of ancient or medieval Asian peoples are still required. Copyright © 2010 John Wiley & Sons, Ltd.     

Integration Processes in European Research and Development: A Comparative Spatial Interaction Approach Using Project Based Research and Development Networks,Co‐Patent Networks and Co‐Publication Networks

This study focuses on integration processes in European Research and Development (R&D) by analyzing the spatiotemporal dimension of three different R&D collaboration networks across Europe. The studied networks cover different types of knowledge creation, namely project‐based R&D networks within the European Union (EU) Framework Programmes (FPs), co‐patent networks, and co‐publication networks. Integration in European R&D—one of the main pillars of the EU Science Technology and Innovation policy—refers to the harmonization of fragmented national research systems across Europe and to the free movement of knowledge and researchers. The objective is to describe and compare spatiotemporal patterns at a regional level and to estimate the evolution of separation effects over the time period 1999–2006 that influence the probability of cross‐region collaborations in the distinct networks under consideration. The study adopts a spatial interaction modeling perspective, econometrically specifying a panel generalized linear model relationship, taking into account spatial autocorrelation among flows using eigenfunction spatial filtering methods. The results show that geographical factors are a lower hurdle for R&D collaborations in the FP networks than in co‐patent networks and co‐publication networks. Furthermore, it is shown that the geographical integration is higher in the FP network.     

The prevalence of,and the relationship between some spinal diseases in a human skeletal population from London

The prevalence of osteoarthritis, osteophytosis, intervertebral disc disease and diffuse idiopathic skeletal hyperostosis (DISH) was determined in a group of skeletons excavated from the crypt of Christ Church, Spitalfields. Age-specific prevalence rates were calculated from the group of skeletons for which age at death was known from intact coffin plates. Osteoarthritis of the facet joints occurred most frequently in the cervical and upper thoracic regions and was also common in the lower lumbar spine. The disease was more frequently bilateral in the lumbar spine than in upper regions. Osteophytes were common in the thoracic and lumbar spines, whereas intervertebral disc disease was confined almost completely to the cervical region. Diffuse idiopathic skeletal hyperostosis seemed to be underrepresented in this group, but was more common in males than in females. Age correlated significantly with all the conditions except DISH. Multiple regression analysis was carried out using each of the conditions as the dependent variable in turn. Age accounted for more of the variance than any of the other conditions added as independent variables.     

Towards Equity in Indigenous Co‐Management of Protected Areas: Cultural Planning by Miriuwung‐Gajerrong People in the Kimberley,Western Australia

Delivery of the potential mutual benefits for biodiversity conservation and Indigenous peoples through protected area co‐management remains challenging, with partnership arrangements frequently delivering inequitable outcomes that marginalise Indigenous interests. In the Kimberley region of Western Australia, Miriuwung‐Gajerrong people initiated a Cultural Planning Framework to help achieve greater equity in planning for co‐management of the first Indigenous‐owned protected areas managed with the state. Analysis of the negotiation and delivery of this Indigenous‐controlled planning initiative concluded it made a key contribution in shaping an equitable intercultural space for ongoing negotiation of co‐management. A practitioners' model of related design concepts drawn from the analysis identified three factors of significance: a foundation platform of recognition of rights and interests; a set of effective organisations to support the roles of the key actors; and effective mechanisms for working together. The model proved robust when evaluated against international standards for best practice, suggesting it may be a useful tool for guiding better uptake of those standards. Interrogation of the two major theories underpinning these standards – common pool resource (CPR) and governance – demonstrated the theories are synergistic and inform different parts of the model. Both theories highlight the significance of Indigenous‐controlled planning. Attention to relational theory for interrogation of the intercultural space may help illuminate their relative importance. Further investigation of the potential of Indigenous‐controlled planning to build theory and practice in Indigenous co‐management of protected areas is recommended.     

Co‐opting Conservation: Migrant Resource Control and Access to National Park Management in the Philippine Uplands

The history of political and economic inequality in forest villages can shape how and why resource use conflicts arise during the evolution of national parks management. In the Philippine uplands, indigenous peoples and migrant settlers co‐exist, compete over land and forest resources, and shape how managers preserve forests through national parks. This article examines how migrants have claimed lands and changed production and exchange relations among the indigenous Tagbanua to build on and benefit from otherwise coercive park management on Palawan Island, the Philippines. Migrant control over productive resources has influenced who, within each group, could sustain agriculture in the face of the state's dominant conservation narrative — valorizing migrant paddy rice and criminalizing Tagbanua swiddens. Upon settling, migrant farmers used new political and economic strengths to tap into provincial political networks in order to be hired at a national park. As a result, they were able to steer management to support paddy rice at the expense of swidden cultivation. While state conservation policy shapes how national parks impact upon local resource access and use, older political economic inequalities in forest villages build on such policies to influence how management affects the livelihoods of poor households.     

Gmo Neighbourhoods – Will Co‐Existence Be A Geographically Realistic Possibility?

In Denmark, there has been widespread opposition to the use of genetically modified organisms (GMOs) as a result of which rules have been developed relating to the co‐existence of GM, conventionally and organically produced crops. This has been in the form of a spatially elaborated implementation of the precautionary principle adopted in the Maastricht Treaty from 1992 by the EU. We concretized these rules in relation to actual landscape practices among primary producers of sugar beet in Denmark, and simulated the co‐existence of GM and conventional sugar beet in an area of intensive sugar beet production in Lolland, South Eastern Denmark. The theoretical basis for our work finds three major sources of inspiration; namely Ulrich Beck's theory of the ‘risk society’, Torsten Hägerstrand's concept of ‘the process landscape’ and its relation to the social practices of land users, and Bri‐an Wynne's studies of the discrepancy between theoretical and practical knowledge related to environmental risk. The farmers, who were involved in the study, were interviewed concerning their opinions on land‐use practices in cases of co‐existence. Interviews were carried out both before and after the study took place. It is concluded that although the farmers are positive towards the possibility of introducing GM sugar beet, it is not realistic to expect the rules of co‐existence to be observed, which makes the risk assessment behind the new rules unrealistic. Further studies of social practice in relation to trends and geographical variations in the distribution of structure, size and fragmentation of agricultural holdings are recommended in order to investigate possibilities for realistic co‐existence.     

Cribra orbitalia and cribra cranii in Roman skeletal remains from the Ravenna area and Rimini (I–IV century AD)

Cribra orbitalia and cribra cranii are considered good indicators of the health and nutritional status of ancient populations, as their presence is often associated with chronic acquired anaemia. The distribution of these lesions in two Roman samples from the Ravenna area and Rimini was considered as a measure of health in relation to their respective environments. Enamel hypoplasia was also assessed as it is symptomatic of childhood physiological stresses such as malnutrition, infectious diseases, physiological traumas, and the like. The differential analysis suggests that the lesions observed are due to chronic acquired anaemia, probably caused by a poor diet, worm infestation, infections and parasitic diseases. Copyright © 2004 John Wiley & Sons, Ltd.     

Institutions,Markets and Economic Co‐ordination: Linking Development Policy to Theory and Praxis

This article explores policy applications of ‘new institutional economics’ theory in relation to markets and economic development. It argues for application of an analytical framework which instead of looking at institutions primarily in terms of their contributions to making competitive markets work better, sees such markets as one form of institution fulfilling exchange and co‐ordination functions in an economy. A key element in this is recognition of the importance of processes of change in non‐standard market arrangements in economic development, and there are strong theoretical, practical and historical grounds for more consistent policy in this area.