Camillo Golgi's Scientific Biography

Born in Corteno, a tiny village in the province of Brescia, Camillo Golgi studied at the University of Pavia where he graduated in medicine in 1865 under the guidance of the psychiatrist Cesare Lombroso who sparked his vocation to study the brain. Golgi then began to learn histological techniques under the direction of the pathologist Giulio Bizzozero. In 1872 he moved to Abbiategrasso as chief of a hospital for chronic diseases. In a rudimentary laboratory he developed the silver-bichromate staining technique, the ‘black reaction’, which was a breakthrough for nervous tissue structure research. While in Abbiategrasso Golgi demonstrated the branching of the axons, and observed striatal and cortical lesions in a case of chorea. He returned to Pavia as Professor of Histology and General Pathology, and made a series of important discoveries that still bear his name: the Golgi tendon organ, the Golgi-Mazzoni corpuscles, another Golgi method to stain nerve cells based on the use of potassium dichromate and mercuric chloride, the canaliculi of the parietal cells of the gastric glands (Müller-Golgi tubules), the Golgi-Rezzonico myelin's annular apparatus (or Golgi-Rezzonico horny funnels), the cycle of malarian parasites (Golgi cycle), the relationship between recurrent malarian fever bouts and the multiplication of the Plasmodium in the blood (Golgi law), the relationship between the vascular pole of the Malpighian glomerulus and the distal tubule, the Golgi's pericellular nets and finally, and most importantly, the cytoplasmic ‘internal reticular apparatus’ (Golgi apparatus). In 1906 Golgi was awarded the Nobel prize for Medicine or Physiology. He died in Pavia on 21 January 1921.     

From the Mind to the Brain: An Unusual Pathway

One of the most unrecognized aspects of Golgi's life was his deep interest in neuropsychiatry. From 1865 to 1868 he attended the Clinica per le Malattie Nervose e Mentali in Pavia directed by Cesare Lombroso, the founder of modern criminology. Golgi was involved in research on the etiology of psychiatric ailments. During this short period of time he produced significant theoretic advances in clinical psychiatry. However, very soon he started to criticize the conceptual approach as well as the nosological system proposed by his academic mentor. In July 1868 he left Lombroso's school in search for a more rational method of studying brain functions and diseases. In spite of his anatomical approach to the central nervous system, he always maintained curiosity in the phenomenology of functional and organic mental disorders. This predisposition is witnessed by his capability to relate clinical observations to neuropathological findings.     

From the mind to the brain: an unusual pathway

One of the most unrecognized aspects of Golgi's life was his deep interest in neuropsychiatry. From 1865 to 1868 he attended the Clinica per le Malattie Nervose e Mentali in Pavia directed by Cesare Lombroso, the founder of modern criminology. Golgi was involved in research on the etiology of psychiatric ailments. During this short period of time he produced significant theoretic advances in clinical psychiatry. However, very soon he started to criticize the conceptual approach as well as the nosological system proposed by his academic mentor. In July 1868 he left Lombroso's school in search for a more rational method of studying brain functions and diseases. In spite of his anatomical approach to the central nervous system, he always maintained curiosity in the phenomenology of functional and organic mental disorders. This predisposition is witnessed by his capability to relate clinical observations to neuropathological findings.     

The discovery of the Golgi apparatus

The existence of the cell organelle which is now known as Golgi apparatus or Golgi complex, or simply as 'the Golgi", was first reported by Camillo Golgi in 1898, when he described in nerve cells an 'internal reticular apparatus' impregnated by a variant of his chromoargentic staining. It soon became clear that the newly-identified cytoplasmic structure occurred in a variety of cell types. However, the reality of the organelle was questioned for decades, until it was finally ascertained with electron microscopy. The Golgi apparatus was destined to become a protagonist of the research in cytology and cell biology pursued in the second half of the twentieth century.     

The impossible interview with the man of the hidden biological structures. Interview by Paolo Mazzarello

This paper presents an "impossible interview" to Professor Camillo Golgi, placed in time in December 1906. The Italian Professor Golgi from Pavia has been awarded the Nobel Prize for Physiology or Medicine ex aequo with the Spanish anatomist Santiago Ramón y Cajal. Both scientists have obtained the award for their work on the anatomy of the nervous system. However, they have opposite views on the mechanisms underlying nervous functions. Golgi believes that the axons stained by his "black reaction" form a continuous anatomical or functional network along which nervous impulses propagate. Ramón y Cajal is the paladin of the neuron theory, a hypothesis questioned by Golgi in his Nobel lecture of Tuesday, December 11. After the ceremony, an independent journalist has interviewed Professor Golgi in the Grand Hotel in Stockholm. Excerpts about his education, his main scientific discoveries, and his personal life are here given (reconstructing the "impossible interview" on the basis of Golgi's original writings).     

塔西佗历史书写中的“年代记”及其政治功能北大核心CSSCI

塔西佗以传统“年代记”体裁写作自奥古斯都到图密善统治时期的历史。他的历史探讨最深刻的人性与政治的关系,以此论证元首政体的好坏与统治者品性之间的联系。塔西佗的政治生涯大部分在图密善时代度过,在图拉真统治时期开始写作历史。图密善的暴政使他对历史写作持谨慎小心的态度,而暴政带来的影响使他希望通过历史写作给贵族阶层提供政治教诲,培育政治上的审慎美德,以便服务于国家。历史写作上的谨慎和提供教诲的愿望,使他放弃了当时流行的皇帝传记体裁而选择传统“年代记”体裁。尽管“年代记”与皇帝传记一样,都把皇帝作为叙述中心,但塔西佗研究的重点是皇帝的统治技巧、计谋和贵族阶层对此的回应,这种叙述体裁的选择因而也是其写作意图的组成部分。     

为共产主义事业奋斗到底的一生--我所了解的晚年陈云(上)

陈云同志的一生是坚贞不渝的共产主义者的一生。他在晚年作为党的第二代中央领导集体的重要成员,为共产主义事业奋斗到底的精神,突出表现在他对改革开放的社会主义方向的把握上,对党的重大原则的坚持上,对党和国家战略的深谋远虑上,对人民群众切身利益的关心上以及对个人的严格要求上。在党的建设方面,他思考最多的,除了搞好党风外,主要是如何端正思想路线、保证党内民主和选拔优秀中青年干部的问题。在经济建设方面,他总是从国家的全局和长远利益出发,关注那些影响我们长期发展的制约因素;并且对计划与市场的关系进行了深入思考,为在微观搞活的同时加强宏观控制提供了理论依据。他时刻挂念人民群众的疾苦,关心群众的切身利益,并力求在制订具体政策中加以体现。他在晚年依然保持谦虚谨慎、顾全大局、艰苦朴素、克己奉公的作风,为我们树立了永葆共产党人政治本色的光辉榜样。     

Book Review

Gustaf Retzius (1842–1919), the Swedish anatomist and anthropologist, and Camillo Golgi were contemporaries. They met on several occasions and came in closer contact when Golgi, together with Ramón y Cajal, was awarded the Nobel Prize in Physiology or Medicine in Stockholm in 1906. Retzius came from an illustrious family. His father was professor of anatomy at Karolinska Institutet and Gustaf himself made a fast career. At 35, he was appointed to a professorship in histology, especially created for him at Karolinska Institutet, and later he became professor of anatomy in the same institution. Retzius was exceedingly productive, and published more than 300 scientific papers, most of which dealt with the nervous system and sensory organs. The majority of these were included in his magnificent volumes Biologische Untersuchungen, Neue Folge (Biological Investigations, New Series), which appeared from 1890 to 1921, and in Das Gehörorgan der Wirbelthiere (“The Acoustic Organ of Vertebrates”, 1881 and 1884), which may be his internationally better known contribution. Much of his work, especially on invertebrates, was based on Ehrlich's methylene blue method, but he also used the Golgi method early on. Particularly his studies of the innervation of the sensory organs became of great importance for the support of the neuron doctrine. His standing internationally was reflected in his membership in many of the most prominent academies abroad, as well as in invitations to him to give a “Croonian Lecture” in 1908 and “The Huxley Lecture” in 1909.     

Gustaf Retzius and Camillo Golgi

Gustaf Retzius (1842-1919), the Swedish anatomist and anthropologist, and Camillo Golgi were contemporaries. They met on several occasions and came in closer contact when Golgi, together with Ramon y Cajal, was awarded the Nobel Prize in Physiology or Medicine in Stockholm in 1906. Retzius came from an illustrious family. His father was professor of anatomy at Karolinska Institutet and Gustaf himself made a fast career. At 35, he was appointed to a professorship in histology, especially created for him at Karolinska Institutet, and later he became professor of anatomy in the same institution. Retzius was exceedingly productive, and published more than 300 scientific papers, most of which dealt with the nervous system and sensory organs. The majority of these were included in his magnificent volumes Biologische Untersuchungen, Neue Folge (Biological Investigation, New Series), which appeared from 1890 to 1921, and in Das Gehororgan der Wirbelthiere ("The Acoustic Organ of Vertebrates", 1881 and 1884), which may be his internationally better know contribution. Much of his work, especially on invertebrates, was based on Ehrlich's methylene blue method, but he also used the Golgi method early on. Particularly his studies of the innervation of the sensory organs became of great importance for the support of the neuron doctrine. His standing internationally was reflected in his membership in many of the most prominent academies abroad, as well as in invitations to him to give a "Croonian Lecture" in 1908 and "The Huxley Lecture" in 1909.     

Alienated Outsider or Integrated Courtier? Edward Stafford,Third Duke of Buckingham, 1498–1521 and the Royal Court

Edward Stafford, third duke of Buckingham (d. 1521), is a key example in the historiographical interpretation of relations between crown and nobility as difficult and in conflict under the first two Tudor kings, not least because of his execution for treason in 1521. In particular, he has been seen as an outsider at the Tudor court, playing little role there except perhaps on great set-piece occasions. He was, in this interpretation, unable to adapt to the new role demanded of the nobility by the crown. Yet, drawing on the evidence of his extant and unpublished household accounts, Stafford can be seen to be very regularly at court under both Henry VII and Henry VIII, playing far more than just a ceremonial role, and it was only shortly before his execution that his relationship with Henry VIII soured. The duke's purposes in his attendance at court – service to the king, furtherance of his own business and leisure interests – can be teased out from the accounts, as can relationships with others at court. The study concludes by examining the extent to which the higher nobility expected to be at court and to be influential with the king in the period between 1485 and 1529. An appendix constructs a full itinerary for the duke for 1 April 1506 – 31 March 1507 from the evidence of a household account.     

The impossible interview with the man of the neuron doctrine. Interview by Edward G Jones

This paper follows the form of that by Mazzarello that precedes it (Mazzarello, 2006) and presents an imaginary interview with Santiago Ramón y Cajal in December 1906. A few days earlier Cajal had been awarded the Nobel Prize for Physiology or Medicine, an award that he shared equally with Professor Camillo Golgi. Golgi had been recognized for his work as a pioneer into investigations of the nervous system, primarily on account of his discovery of the "black reaction" of silver chromate impregnation of whole nerve cells and their processes. Cajal had been recognized for his implementation of that method and for laying with it the foundations of what was to become modern neuroanatomical science. Paradoxically, the two awardees had been led by their researches to diametrically opposed views of the organization of the nervous system. Golgi believed in a continuous network of axons that formed the basis of all the integrative properties of the nervous system, while Cajal had provided the information that led to the formulation of the neuron doctrine that saw the nervous system as being made up of chains of discontinuous cells joined by polarized functional contacts that we now call synapses. The paper takes the form of an interview with Professor Cajal in the Grand Hotel Stockholm. His responses to questions posed by the imaginary interviewer are all taken from Cajal's own writings.     

New books: Publishers' announcements

The conventional view of Giotto is that he was a great narrative and dramatic painter. In addition his art was ideologically aligned with the Guelph party in Florence and its allies: the papacy, the Franciscan establishment and the house of Anjou. This can be traced in his paintings, especially the fresco cycles. Internal evidence suggests that in addition to his acknowledged cycle for the Scrovegni family in Padua he was the principal artistic deviser of many of the disputed frescoes in the nave of the Upper Church at Assisi, including the paintings of the life of St. Francis.There is also evidence that many of his frescoes in various parts of Italy (including cycles no longer extant) were undertaken at the behest of the Florentine commune as part of its diplomacy. He was in fact the first artist to become part of the bourgeois ruling class, and his spatial and plastic realism was in complete accord with their interests.The Scrovegni cycle is more complex than has been realised, involving a profound allegory which fulfils the needs of the patron, expresses Giotto's world view, and at the same time serves the diplomatic interest of Florence.     

Giotto: artistic realism,political realism

The conventional view of Giotto is that he was a great narrative and dramatic painter. In addition his art was ideologically aligned with the Guelph party in Florence and its allies: the papacy, the Franciscan establishment and the house of Anjou. This can be traced in his paintings, especially the fresco cycles. Internal evidence suggests that in addition to his acknowledged cycle for the Scrovegni family in Padua he was the principal artistic deviser of many of the disputed frescoes in the nave of the Upper Church at Assisi, including the paintings of the life of St. Francis.There is also evidence that many of his frescoes in various parts of Italy (including cycles no longer extant) were undertaken at the behest of the Florentine commune as part of its diplomacy. He was in fact the first artist to become part of the bourgeois ruling class, and his spatial and plastic realism was in complete accord with their interests.The Scrovegni cycle is more complex than has been realised, involving a profound allegory which fulfils the needs of the patron, expresses Giotto's world view, and at the same time serves the diplomatic interest of Florence.     

Front and Back Covers,Volume 36, Number 2. April 2020

Front and back cover caption, volume 36 issue 2 Front cover CRISIS IN VENEZUELA Shop owner Alejandro Malek shows hundreds of banknotes that he has accepted from customers who buy their daily groceries in his small supermarket near the border between Venezuela and Brazil. He also accepts Brazilian reals, US dollars and gold. Malek is a migrant himself and arrived almost 30 years ago in the country. He poses for the picture with packs of bolivares soberanos to express his love for Venezuela. Big packs of banknotes to purchase basic goods have become normal for many Venezuelans since hyperinflation reached mind-boggling levels. Basic goods, such as toilet paper and cornflour, are unavailable or simply unaffordable for more than 90 per cent of the population. Since 2015, the economy has been in free fall and Venezuelans look for countless means to survive. In times of crisis, people seek to make ends meet by joining the informal economy outside the official structures. The thriving local emergency economy of banknotes, gold, food, petrol and medicine in Venezuela ties into illegal transnational networks which commercialize natural resources, people, drugs and weapons that stretch far beyond the Latin American region. In this issue, Eva van Roekel and Marjo de Theije suggest an anthropology of abundance to study the illicit manifestations and everyday ideals of wealth that accompany social and environmental crises in resource-rich countries like Venezuela. Back cover THE SHAMAN VS PUTIN In spring 2019, Aleksandr Gabyshev, a Sakha (Yakut) shaman, embarked on an 8,000 km trek from Yakutsk to Moscow. His stated goal was to ‘expel demon-Putin’ (izgnat' Putina-demona) from the Kremlin and thus liberate the people of Russia. Drawing a cart with supplies and necessities, he slowly progressed along Siberian highways, camping on roadsides along the way. While initially his journey attracted little attention beyond local cybernauts, by the end of the summer, word of Gabyshev's campaign had spread far and wide. Around a dozen people (his ‘squad’) joined his trek, while many more stopped him along the way to chat, take a picture, express support and offer supplies. On 19 September, Gabyshev's trek came to a halt almost 3,000 km in. He was arrested by the authorities in the Republic of Buryatia, as he and his ‘squad’ were approaching Irkutskaya Oblast. The shaman was flown back to Yakutsk where he underwent a psychiatric examination. He is facing charges on account of ‘calls to extremism’ and was put under travel restrictions for several months. He attempted another short-lived, unsuccessful trek in December 2019, again stopped by the authorities. Recently, Gabyshev announced that he would continue the trek in spring 2020 and reach Moscow in 2021, expressing confidence in the impending success of his undertaking. In this issue, Kristina Jonutyte shows how this shaman's campaign has attracted a lot of attention within Russia, especially on the Internet and social media. Many have expressed their interest in and support for the campaign, while at the same time ‘distancing’ the shaman in time and space, as well as along the lines of ‘rationality’.     

渐中语类——俞伟超先生晚年思想随录

2003年下半年俞伟超先生在广州医疾期间,后学多次探望,并就诸多问题请教先生,先生所谈内容涉及人文科学、科学与信仰、水下考古以及考古学与哲学、文学、艺术等关系。先生说自己的人生是人文上的东西,希望学生研究他的人文道路。     

Von der Wissenschaftsverwaltung zur Wissenschaftspolitik. Friedrich Althoff (19. 2. 1839-20. 10. 1908)

Friedrich Althoff (1839–1908) was one of Germany's three great administrators of science and humanities between Wilhelm von Humboldt (1767–1835) and Carl Heinrich Becker (1886–1933). He was perhaps the most prominent representative of Prussian bureaucratic liberalism and the first eminent politician of culture or — in the words of W. H. Dawson — “the most enlightened but also the most dictatorial Minister of Education Prussia has ever had”. Althoff dominated the state administration of higher education in Prussia between 1882 and 1907, serving as Ministerial director over higher educational affairs under at least four ministers. The so-called “Althoff system”, that he built pushed the development of German science and scholarship to a dominant position in the world, rationalized the universities and further subordinated them to state or ministerial policy through a rigid control of professional appointments, started the mobilization of private capital in support of German scientific hegemony (founding of Kaiser-Wilhelm-Gesellschaft), and put forward the Prussian tradition — ultimately an unsustainable one — of strong personal administration, by which Althoff systematically manipulated or overrode the very bureaucratic apparatus he had helped to create. On the other hand his policy defended academic freedom, patronized Catholic and Jewish scholars against reactionary university faculties as well as the so-called Kathedersozialisten against the influences of big business and laissez-faire capitalism. As a creator of german cultural foreign policy he paved the way for more international understanding and peace policy, an alternative to the war-aims policy of Imperial Germany on the eve of the Great War.     

明末清初文人命运之管窥——侯方域生平考

侯方域是明末清初著名的文人之一,他出生于名门望族,受过良好的教育,很早就名满天下。他早年交游广阔,与当时的一帮名士朝夕对酒作诗,品评当世人物,颇有济世之志。后来,因得罪了小人,自己落得四处飘零,又由于农民战争及清军的蹂躏,他的大部分好友都散去或死去;明清易代,他又成了夹缝中的遗民。他虽然英年早逝,但短暂的一生却历经巨变沧桑。