Serendipity and the Cerebral Localization of Pleasure

Most accounts of the discovery of “pleasure” circuits in the brain begin with the observation by James Olds and Peter Milner in 1953 that electrical brain stimulation can condition operant responses in rats. Less well-known, pleasurable brain stimulation was previously observed in schizophrenic patients by Robert Heath. However, Heath failed to recognize the significance of this observation, at least in part, because of preconceived notions he held about the etiology of schizophrenia. This episode in the history of neuroscience illustrates the importance of sagacity in serendipitous scientific discoveries. It also shows that “mental preparedness” can be an obstacle to progress.     

Serendipity and the cerebral localization of pleasure

Most accounts of the discovery of "pleasure" circuits in the brain begin with the observation by James Olds and Peter Milner in 1953 that electrical brain stimulation can condition operant responses in rats. Less well-known, pleasurable brain stimulation was previously observed in schizophrenic patients by Robert Heath. However, Heath failed to recognize the significance of this observation, at least in part, because of preconceived notions he held about the etiology of schizophrenia. This episode in the history of neuroscience illustrates the importance of sagacity in serendipitous scientific discoveries. It also shows that "mental preparedness" can be an obstacle to progress.     

The Tulane Electrical Brain Stimulation Program a historical case study in medical ethics

In 1950 physicians at Tulane University School of Medicine began a program of research on the use of electrical brain stimulation that would span three decades and involve approximately 100 patients. Initially, electrical brain stimulation was used to treat of schizophrenia, but later it was applied to a variety of other conditions. Throughout its history the Tulane research was well publicized in both the professional and lay literature, and for almost twenty years, with rare exception, these accounts were laudatory. However, in the early 1970s this work began to draw sharp public criticism. Despite its public and controversial nature, the Tulane electrical brain stimulation program has received relatively little attention from historians. This review recounts the history of the Tulane program with particular emphasis on the ethical propriety of the work. Factors that shaped the historical context in which the Tulane experiments were conducted are discussed.     

Coles Creek fauna procurement strategies: subsistence diversity among late prehistoric hunter-gatherer-horticulturalists in the Lower Mississippi Valley

In the late 1980s, a collaborative effort between Harvard University’s Lower Mississippi Survey and Tulane University’s Center for Archaeology launched a study examining the causes and consequences of subsistence change in the Lower Mississippi Valley. The Osceola Project contributed the first formal study of late prehistoric faunal remains within the Alluvial Plain, becoming the standard against which all subsequent Coles Creek faunal assemblages have been measured. Recent evidence recovered from three sites located in the Eastern Uplands presented the opportunity to compare and contrast vertebrate subsistence in these two distinct physiographic regions. We hypothesize that a clear distinction exists between lowland and upland Coles Creek procurement strategies. This article evaluates this claim by examining species diversity, spatial patterns, and temporal trends evident within an eight-site sample. The results suggest that the primary factor influencing Coles Creek fauna procurement was the immediate environment, and that the composition of Late Woodland period diets may be a reflection of efficiency of effort rather than food access or scarcity.     

A first fossil record for Scolytus scolytus (F.) (elm bark beetle): its occurrence in elm decline deposits from London and the implications for neolithic elm disease

A problem which has arisen in discussions of an elm-disease explanation for the Neolithic elm decline has been the lack of fossil records of Scolytus scolytus (F.) (elm bark beetle), which is the main carrier of the fungus which causes the present epidemic of Dutch Elm Disease. Now, the discovery of wing cases of two individuals from elm decline deposits at Hampstead Heath, London, proves that the beetle was present in Britain during this episode. The deposits in which it occurs are described, and the various implications for elm disease causing, aiding or at least occurring during this stage of the early Neolithic are discussed.     

Schizophrenia, reification and deadened life

Recent debates concerning the abolition of the schizophrenia label in psychiatry have focused upon problems with the scientific status of the concept. In this article, I argue that rather than attacking schizophrenia for its lack of scientific validity, we should focus on the conceptual history of this label. I reconstruct a specific tradition when exploring the conceptual history of schizophrenia. This is the concern with the question of the sense of life itself, conducted through the confrontation with schizophrenia as a form of life that does not live, or as Robert Jay Lifton termed it "lifeless life" (1979: 222-39). I conclude by arguing that the contemporary attempt to deconstruct or abolish the schizophrenia concept involves a fundamental shift in concern. The attempt both to normalize psychotic experiences, and to conceive them purely in terms of cognitive processes that can be mapped onto brain function, results in a fundamental move away from the attempt to understand the experience of madness.     

Historical development of the dopamine hypothesis of schizophrenia

This review examines the history of discoveries that contributed to development of the dopamine hypothesis of schizophrenia. The origin of the hypothesis is traced to the recognition that neuroleptic drugs interfere with brain dopamine function. This insight was derived from two distinct lines of research. The first line originated from the discovery in 1956 that reserpine depletes brain serotonin. This finding resulted in a sequence of studies that led to the discovery that brain dopamine is involved in neuroleptic-induced extrapyramidal motor disturbances. The second line of research was aimed at determining the mechanism of action of psychomotor stimulants. This research produced evidence that stimulants directly or indirectly activate brain dopamine receptors. Because nonreserpine neuroleptics such as chlorpromazine block stimulant-induced movement, these findings suggested that neuroleptics were dopamine antagonists. Most previous accounts of the development of the dopamine hypothesis of schizophrenia emphasize the first line of research and ignore the second.     

Historical Development of the Dopamine Hypothesis of Schizophrenia

This review examines the history of discoveries that contributed to development of the dopamine hypothesis of schizophrenia. The origin of the hypothesis is traced to the recognition that neuroleptic drugs interfere with brain dopamine function. This insight was derived from two distinct lines of research. The first line originated from the discovery in 1956 that reserpine depletes brain serotonin. This finding resulted in a sequence of studies that led to the discovery that brain dopamine is involved in neuroleptic-induced extrapyramidal motor disturbances. The second line of research was aimed at determining the mechanism of action of psychomotor stimulants. This research produced evidence that stimulants directly or indirectly activate brain dopamine receptors. Because nonreserpine neuroleptics such as chlorpromazine block stimulant-induced movement, these findings suggested that neuroleptics were dopamine antagonists. Most previous accounts of the development of the dopamine hypothesis of schizophrenia emphasize the first line of research and ignore the second.     

Chance,Creativity, and the Discovery of the Nerve Growth Factor

This essay analyzes the history of the Nerve Growth Factor (NGF) discovery, relating some of the principles of the theory of scientific creativity to the cognitive and personal qualities of the scientists that participated in the discovery, particulary Rita Levi-Montalcini and Viktor Hamburger. The discovery of NGF is especially attractive for the history of science as it involves chance, luck, creativity, and some extraordinary scientists.     

The Heath Government and British Defence Policy in Southeast Asia at the End of Empire (1970-71)

This article examines the rationale behind the Heath government's1970 decision to negotiate a Five Power Defence agreement withAustralia, New Zealand, Singapore and Malaysia and to maintaina small British military contingent in Southeast Asia as a partof this new politico-military framework. It argues that whileits overriding foreign policy concern was to end Britain's problematicrelationship with the European Economic Community and to makemembership of this grouping the cornerstone of its foreign policy,the Heath government was careful not to cast Britain's post-imperialfuture in purely European terms. The successful negotiationof the Five Power Defence Arrangements in 1970–71 wasinstrumental in achieving this by ensuring that London wouldmaintain close links with key Commonwealth partners in the Asianregion. In what was not only an attempt to neutralize potentialdomestic opposition to Britain's entry into the EEC, but alsoa lingering reluctance to do away with the rhetoric of Britainas a leading power with extra-European interests, Heath waseager to show that by making a contribution to the stabilityof Southeast Asia, Britain still had a role to play outsideEurope.     

Chance, creativity, and the discovery of the nerve growth factor

This essay analyzes the history of the Nerve Growth Factor (NGF) discovery, relating some of the principles of the theory of scientific creativity to the cognitive and personal qualities of the scientists that participated in the discovery, particularly Rita Levi-Montalcini and Viktor Hamburger. The discovery of NGF is especially attractive for the history of science as it involves chance, luck, creativity, and some extraordinary scientists.     

Streptomycin, Schatz v. Waksman, and the balance of credit for discovery

A recent article in Nature, arguing that "the misallocation of credit is endemic in science," used Selman Waksman as an illustration, claiming that the true discoverer of streptomycin was one of his graduate students. The article received wide publicity and seriously damaged Waksman's great reputation. What actually happened was that the success of penicillin stimulated Merck to fund research by Waksman, a soil scientist, into the collection of actinomycetes that he had assembled over thirty years. He applied the systematic, uncreative testing techniques that had made the German pharmaceutical industry so successful to these, and streptomycin was discovered within a matter of months. Work in the Mayo Institute then showed that it was marvelously effective against tuberculosis, and Waksman received the Nobel Prize for it in 1952. The test that turned out to be the crucial one could have been carried out by any of several students, but the lucky one was Albert Schatz. He then sued the university for a share of the royalties payable by Merck and also petitioned the Nobel committee to include him in the award. Although he obtained a very substantial out-of-court settlement, this probably damaged his subsequent academic career, and he has never ceased to argue his case for recognition, of which the Nature article is a reflection. To claim that Waksman took credit properly due to Schatz is to fail to understand that once pharmaceutical research had become primarily a matter of large-scale, routine testing, little individual creativity was left in this work. Credit for any successful results must therefore be given to whoever is the originator or director of a particular program. Nature refused to publish evidence that this case could not be used as an example of misallocation of credit for discovery. This in itself illustrates that editors of scientific journals should be every bit as mindful of scientists' reputations as they are of scientific facts.     

Representations of electricity: the development of a visual language for electrical phenomena

Abstract

This paper has two primary objectives. First, it addresses the development of an iconography for electrical phenomena in the eighteenth century, showing how scientific progress influenced artistic images, and how, eventually, Franklin's revolutionary discovery that lightning is an electric discharge made it possible to use a zigzag line (already used at the time as the iconographic symbol for lightning) as a sign for electricity. Second, it investigates the creation and evolution of conventions for scientific illustrations. The following original argument is also introduced: that the stylistic ideals of Classicism influenced scientific illustration in the period around 1800.     

Pessimism and Optimism in Judicial Reform

Book Reviewed in this article
Philip L. Dubois (editor) The Analysis of Judicial Reform (Lexington, Mass.: Lexington Books; D.C. Heath and Company, 1982); 221 pp.; ISBN 0-669-04480-6; $23.95.
Philip L. Dubois (editor) The Politics of Judicial Reform (Lexington, Mass.: Lexington Books; D.C. Heath and Company, 1982); 187 pp.; ISBN 0-669-04478-4; $24.95 cloth.     

The “Science” of Policy Development During Administrative Rulemaking

The legitimacy of government agencies rests in part on the premise that public administrators use scientific evidence to make policy decisions. Yet, what happens when there is no consensus in the scientific evidence—i.e., when the science is in conflict? I theorize that scientific conflict yields greater policy change during administrative policymaking. I assess this claim using data from the U.S. Food and Drug Administration (FDA). I identify policy change—what I refer to as “policy development” in this article—between the FDA's draft and final rules with a novel text analysis measure of shifts in regulatory restrictions. I then go on to find that more policy development does occur with scientific conflict. Moreover, using corresponding survey data, I uncover suggestive evidence that one beneficiary of such conflict may be participating interest groups. Groups lobby harder—and attempt to change more of the rule—during conflict, while an in‐survey experiment provides evidence of increased interest group influence on rule content when scientific conflict is high.     

REGION‐BUILDING IN THE ARCTIC PERIPHERY: THE DISCURSIVE CONSTRUCTION OF A PETROLEUM REGION

As social communities, regions are built through discourses that convey images of what the region is. Regions are built for a variety of reasons, including political and economic ones. This implies that changing economic circumstances have the potential to change the discourses on regional identities. Petroleum discoveries represent such a potential change in the economic circumstances of a region. This study of an emerging petroleum region in the north of Norway shows that a regional identity discourse is used to claim ownership over the petroleum resources in the Barents Sea in order to justify the need for a production plan that maximizes regional economic benefits. In this way, the discovery of petroleum represents an opportunity to reinforce regional identities around a set of common interests. However, “the region” is vaguely defined in this discourse, being used in reference to two different scales: Finnmark and Northern Norway.     

History of the Discovery of the Antipsychotic Dopamine D2 Receptor: A Basis for the Dopamine Hypothesis of Schizophrenia

The 1975 publication of Seeman et al. (Proc Nat Acad Sci, USA), reporting the discovery of the antipsychotic receptor in the brain, is a classic example of translational medicine research. In searching for a pathophysiological mechanism of psychosis, the team sought to identify sites that bound the antipsychotic drug haloperidol. Their criterion was that haloperidol bound to the site at one to two nanomoles per liter, corresponding to haloperidol concentrations found in spinal fluid or plasma water in treated patients. They requested de novo synthesis of tritiated haloperidol, and it readily detected specific haloperidol binding sites in brain striatum. With dopamine binding the haloperidol-labeled sites with higher potency than other neurotransmitters, the sites were named antipsychotic/dopamine receptors (now designated dopamine D2 receptors). Most significantly, they found that all antipsychotics bound these sites at concentrations and with a rank order of potencies that were directly related to the mean daily antipsychotic dose taken by patients with schizophrenia. Their findings enabled screening for new antipsychotics, initiated D2 receptor measurements in brain of living patients, and determination of minimum occupancy (65%) of D2 receptors for antipsychotic benefit. The collective work is generally viewed as providing a fundamental basis for the dopamine hypothesis of schizophrenia.     

On reading the scriptures as literature

Samuel Taylor Coleridge's thought has been seen by many scholars to be derivative of German Idealism, especially Kantian critical philosophy. The present article challenges that claim by offering an analysis of Coleridge's interpretation of Francis Bacon's founding of the empirical method. Through the course of this discussion, Coleridge's understanding of the distinction between the intellective faculties of reason and understanding will be established, and will be shown to run counter to Kantian epistemology. Coleridge's dialectical approach to the role of reason in the operations of the understanding will be applied to their uses in scientific discovery, aesthetics, and religious thought. The various uses of symbolic representation in the context of these different endeavors will be given critical expression, revealing the unity of the human mind and nature, of subject and object. Ultimately, it is by appeal to the existence of God that the intelligibility of these various fields of symbolic representation are established. Coleridge's interpretation of Bacon offers a way of reconciling Baconian empiricism with Platonic Forms, in a genealogical recovery of the concealed methodology established in his Novum Organum. The overall argument proceeds critically, through a discussion of the subjective operations of the symbol-making powers of human thought, in the sciences and mathematics, in aesthetic, and in theological speculation and religious representation, revealing the Romantic origins of modernity.     

The Shared Cognitive Intent of Science and Theatre

Science and theatre are generally thought to share no common cognitive ground for the simple reason that the former appeals to the intellect, whereas the latter appeals to the emotions. Contrary to this view, I claim that like scientific texts, theatrical texts evince a cognitive intent and that, despite obvious differences, both types show similarities on three cognitive levels: (a) the use of equivalent systems of representation and communication; (b) the operation of a mode of thinking; and (c) the embodiment of a rhetorical structure.     

Strength without Mercy: Winston Churchill on Technology and the Fate of Civilization

Abstract

Churchill's lifelong meditation on scientific progress led him to search for ways in which its transformative power could be moderated and guided for the preservation of civilization. The increasing role of scientific discovery and technological innovation in maximizing the destructive potential of warfare, Churchill believed, had brought a moment of decision for humanity: Whether to foster and maintain the moral and political principles that formed the foundation of civilized life or to trust wholly in an amoral science. He found guidance in the study of the humanities, Anglo-American constitutionalism, and Christian ethics.