From DOPA to Parkinson's disease: the early history of dopamine research

Dopamine is among the most well-researched neurotransmitters at the present time. For the first half-century of neurotransmitter research, however, interest in dopamine was minimal, and only a few scattered groups of researchers studied it. It was their research that stimulated current interest, and provided the background for our present understanding of this important substance. By the late 1950s, it was clear to these individuals that dopamine served an important physiological role in mammalian brains, and that its role was most likely that of a central nervous system agonist. Soon after this, dopamine, or more specifically the depletion of dopamine, was clearly implicated in Parkinson's disease. This paper looks at the early history of the physiological roles of this intriguing compound.     

Bridging the cultures: architecture,models and computers in 1960s Cambridge

ABSTRACT

In the 1960s a unique research centre was founded in the Department of Architecture at the University of Cambridge. Before that date research in architecture was fragmentary and consisted largely of individual studies of topics in architectural history. Under the direction of Sir Leslie Martin, who had been appointed Professor of Architecture in 1956, a group of young architecture graduates embarked on a programme of research in the newly established centre for Land Use and Built Form Studies. Informed by the interest in the idea of the ‘model’ that was prevalent across the disciplines in Cambridge at this time and by using the power of the University Mathematical Laboratory’s ‘Titan’ mainframe computer, the group developed conceptual and mathematical models that operated across the range of architectural scales from building to city. This paper describes that work and sets it in the context of Leslie Martin’s role in reshaping architectural education in Britain.     

The emergence of french research policy: Methodological and historiographical problems (1945–1970) 1

French research policy has been of interest to historians for quite some time. However, the very notion has become so evident for us that its history is told as an heroic one of the state's progressive awareness of the importance of the scientific field.

Nevertheless, this historiographical tradition appears misleading. The stress put on the search for ancestors obscures many issues. This paper accordingly tries to reconstruct a quite different picture underlining the heterogeneity of the meaning of research policy.

The aim is to give a different status to the notion in the context of post‐war France. Science policy should cease to be considered as an evident entity and be seen as an object which organizes and stimulates reflection around the development of science.

After suggesting important themes needed to tackle anew research policy, this study of the major characteristics of the French case ends with a brief account of the progressive definition of the object “research policy”. Focusing on a kind of historical geography of the use and practices of this object, it stresses discontinuities, oppositions and compromises, and also the important work needed to achieve political legitimacy.     

Time‐bound theories about the origin of the Finns

It is a well‐known fact that the present transforms the past at least as much as the past guides the present. The origins of the Finns can be reviewed from two perspectives; firstly, in terms of how local communities explained this question at different periods, and secondly, how the nation's scholarly community explained the matter. This article discusses the latter. I must stress that it simplifies the process it describes and does not rely on a wide range of research materials. It is simply meant to provoke and encourage researchers and scholars to address the social context of previous answers to the question of origin.     

Incipient urbanism at the Early Andean center of Khonkho Wankane,Bolivia

Abstract

For decades archaeologists have recognized that Khonkho Wankane was an important monumental site in the Bolivian Andes, and most have interpreted it as a Tiwanaku regional center. A decade of research indicates that Khonkho Wankane was an important Late Formative center that engendered Tiwanaku’s Middle Horizon urbanism and ritual-political centrality. It was neither a Tiwanaku regional center nor Tiwanaku’s second city. Furthermore, recent research at Khonkho suggests a critique of the “one center, one polity” model of political complexity. Rather than being the singular center of a spatially bounded multi-community polity, Khonkho was one of multiple interacting Late Formative centers in an emergent macro-community that gave rise to Tiwanaku urban centrality.     

The politics of area conservation in Cairo

The historic core of the Arab‐Islamic city has always played an integral role in the formation of the identity of the contemporary Arab city. It serves as the reference for the city’s character. This is especially so in Cairo, where historic quarters still act as the city’s most influential social and cultural source of inspiration. Today, many forces of neglect and deterioration have diminished this role. While attempts have been launched to confront this situation, they have focused mainly on restoring the historic city of Cairo, itself a World Heritage Site. This paper probes the actual reasons for the deterioration of the historic core of Cairo, as well as those that dominate the current efforts for revitalisation. In these processes it is the political dimension that is the most influential in the decision‐making affecting the proposed urban changes in historic Cairo.1 The present inquiry was supported by a workshop organised by the author to examine the attitude of the professionals representing different organisations involved in conservation in historic Cairo. This workshop was held on 12 and 13 September 2001 at the Italian Archaeological Centre in Cairo as part of the empirical work of the author’s PhD research.      

Technology and ocean‐scape: Defining the deep sea in mid‐nineteenth century

The ocean's profound inaccessibility makes it impossible to comprehend except through the mediation of technology. The first investigators to explore the great depths were hydrographers whose work was animated by mid‐nineteenth century growth of political, economic, and cultural interest in the oceans. While submarine telegraphy certainly boosted ocean science, interest in this field derived first from commercial concerns related to whaling and shipping as well as the intellectual pursuits of physical geography and questions about the existence of life at great depths. Hydrographers’ developing conception of the oceanic environment never represented a clear translation from technology. Dramatic changes in the understanding of the shape of the deep‐sea floor testified to the complexity of interaction between sounding machines, methods, and interpretations of depth. The shifting image of the sea floor not only reflected increasingly accurate measurements, but also mirrored shifting human motivations for studying this unexplored territory.     

Communities,families and migration: some evidence from Cornwall

Abstract

Taking its cue from Pooley and Turnbull's (1998) claim that there is no evidence of any difference in the propensity to migrate by region or settlement size, this article investigates the appropriate scale for migration research. It presents some preliminary findings from a micro-level study of three occupationally contrasting communities in Cornwall in the second half of the 19th century. Reconstructing the migration histories of a cohort of children from the 1851 census enumerators' books and making use of local and online census and civil registration index databases, the study identifies some clear differences in migration patterns and propensity at the community level. Moving from patterns to processes it argues that labour markets and occupational structures remain the most important explanatory variables structuring migration, but that these were mediated at the individual level by the influence of the family which played a key role in facilitating or deterring movement.     

A simulation exercise on scientific research for use in undergraduate teaching

Abstract

Commonly used teaching methods concentrate on developing an understanding and knowledge of subject‐matter. Students therefore get little practice in developing important skills such as designing experiments, evaluating data, making decisions and solving complex real problems. Simulations allow students to develop these and other skills and at the same time to increase their understanding of subject‐matter. The simulation described is based upon real research topics which took many years to complete. It is structured so that students can appreciate most of the decision‐making involved in the various stages of research projects.     

Small change: economics and coin-trees in Britain and Ireland

Abstract

Throughout the c. 2,000-year period coins have been circulated in Britain, they have also been ritually employed, most notably as votive deposits. Focusing specifically on the understudied custom of the British coin-tree, whereby coins are ritually embedded into the barks of trees, this paper considers the coin’s role and applicability as a deposit. It aims to demonstrate that our understanding of the coin’s past, present and future ritual employment is not only aided by a consideration of economics and the coin’s secular function; it would be utterly incomplete without it.     

Educational Innovation and the Market for Geographers in Hungary

This paper examines the status of geography in higher education in Hungary. Stress is placed on reforms begun in the 1990s to launch new curricula for training professional geographers. The authors played an important role in developing this new curriculum by introducing new subjects into geography programmes, working out the scope and sequence of courses, obtaining accreditation and carrying out market research for graduates. The project was motivated by a decline in demand for geography and geography teachers in secondary schools accompanied by an increase in demand for geographers trained to work in public administration, government and business. The graduates of the new professional geographer curriculum receive a practice-oriented education designed to cultivate their spatial problem solving and applied geographical skills. In this paper the authors present the steps in the curriculum reform and suggest that it may serve as a model for reform in a number of nearby countries planning to join the EU.     

JFK and dark tourism: A fascination with assassination

Abstract

This paper sets out to explore the phenomenon that the authors have entitled Dark Tourism and to analyse evidence of its existence in the context of sites associated with the life and death of the former US President, John F. Kennedy (JFK). These sites present front‐line staff, curators, and development bodies with dilemmas concerning legitimacy of presentation/representation and lead to questions about the, often cited, educational mission, of such attractions. The media has had a central role in the development of this phenomenon and documentation and illustration via news and film has been central to much of the interpretation of JFK and the Kennedys. This paper considers media fascination with this subject and examines exploitation of this interest at three, contrasting sites.     

The landscape of Metztitlan,Mexico: Power and control in a sixteenth century Spanish administrative painting

ABSTRACT

The concept of landscape has been studied mostly as the view of a space with particular interest in its aesthetics, originating at the turn of the sixteenth century. However, I argue that in fourteenth century northern Europe, the concept was focused on polity rather than aesthetics. This article examines this lesser-known tradition by analysing the painting of Metztitlan, a sixteenth century town in Mexico, and arguing, first, that unlike all the other representations in the Relaciones Geográficas to which it belongs, it is the only landscape, and second, that this painting is associated with an administrative procedure common in Spain to gain control over imperial lands. I review European practices regarding the representation of towns under the Spanish Crown. Then, I present the results of the fieldwork carried out to locate several heights which probably served as vantage points to paint the landscape. Based on this research, I analyse the intentions of the painter to argue that it should be considered within the same tradition as the paintings made in Spain by Flemish painter Anton van de Wyngaerde, as part of the Spanish Empire's Germanic tradition of describing places with the intention of exerting control over them.     

The Two-Wood Bow

The invention of long-range weapons has played an important role in the evolution of human culture. The evolution of the bow in particular has held a central position in this process. A reconstruction of the steps by which the bow evolved is therefore of considerable interest. In this process the use of two separate types of wood, the invention of strong glues, the evolution of stiff ends, which act as levers, and the discovery of the mechanical characteristics of horn and sinew are key technical innovations. Previous research has often focussed on the evolution of the horn bow, or the composite bow as it also is called. On the other hand, the type of bow that is typical of northern Asia, the two-wood bow, has attracted little interest. This paper treats the evolution of the bow in Scandinavia, with focus on the two-wood bow. To put the two-wood bow in perspective, archaeological records and rock-carvings are analysed. This study highlights some new aspects of the early evolution of the bow, where the two-wood bow is, for the first time, assigned an important role. It is classified as a distinct type, which, moreover, formed an important stage in the evolution of the bow.     

Bishop Bickersteth’s Visitation Returns for the Archdeaconry of Craven,Diocese of Ripon, 1858

Abstract

In 1868, an article in the Yorkshire Post about the West Riding Pauper Lunatic Asylum drew attention to Yorkshire's pivotal role in the history of mental health care. It was because of this history, it was claimed, that Yorkshiremen had a special interest in the treatment of the insane. The purpose of this paper is to explore critically this assumption in light of the recent work on the Poor Law's relationship with the asylum. The growth and development of two asylums in the neighbouring North and West Ridings of Yorkshire will be compared and contrasted. The first part of the paper offers a brief explanation of Yorkshire's pivotal role in the history of the institutional approach to the problems of mental health and the growth of institutions in the counties. Central to the paper will be an examination of how each county responded to the differing demands on its resources and how this impacted on the nature of care at each institution. Ultimately, this paper aims to show how Poor Law finances contributed significantly to the development of each institution.     

„Und nur die Zukunft wird Klarheit bringen!”︁Der Fall des Biomediziners Jacques Benveniste aus dem Jahr 1988 im Blickfeld der wissenschaftlichen Publikationsorgane und der Laienpresse

Scientific disputes on the objectivity of research results are an integral part of the collective production of knowledge. One motivation to study cases of scientific controversy is the attempt to discover general patterns in the behaviour of participants and institutions involved in such controversies. Yet, for there to be a controversy, one must assume an important amount of social interaction, so much so that it renders it an essentially social phenomenon, which is accessible to historical study. Cases of obvious scientific fraud, in addition, are neither clear‐cut nor rare and the mere accusation of scientists by their peers frequently constitutes considerable examples of scientific debate. Together with this, it is often assumed that publication organs play a dominant role in directing the lines of scientific controversy, but their institutional significance and the task of individual editors remain widely unexplored. The present article studies the prominent Nature affair of the Parisian biomedical scientist Jacques Benveniste, both, from a perspective on scientific fraud and on the beginning and closure of scientific disputes. One of the most remarkable features of Benveniste's antibody dilution experiments was that they stroke at the foundations of modern physical and biomedical sciences. Could recent history of science actually resolve the case of the so‐called ‘memory of water’ phenomenon?     

Strategies in northern development in Canada since the late 1960's

From the late 1960's onwards the northern part of North America has undergone the most significant social, political and economic transformation in its history.

This paper will look at some of the main reference points in the political economy of northern Canada, and will overlay this with a review of the evolution of key development strategies, policy statements, and mega‐project impact assessments that have happened during the past two decades.

Significant shifts in northern development perspectives have occured throughout this period; these will be analyzed and some important future trends and issues will be discussed.     

Georg Friedrich Handel's strokes*

Abstract

Although there is no definite proof, it seems most likely that Georg Friedrich Handel suffered from cere‐brovascular disease, which caused two or three minor strokes and weakness of his eyesight in his last years. His etiologically important risk factors and the symptoms of Handel's strokes are presented and evaluated by primary sources; various diagnoses are discussed. In Handel's musical work, no direct impact from his illness can be found, but there are some indirect outflows of Handel's pathography on his compositions, especially the Messiah.     

Slingsby Bethel's Analysis of State Interests

Summary

Seventeenth-century thinking on the relationship between trade and state power was routinely conducted using the concept of state interests, which enabled users to conceive a Europe of competing states that managed the balance of power through trade and war. Poor interest management could arise from ignorance, error, or the divergence between the private interests of rulers and a state's true interests. The stakes of pursuing or neglecting true interest were high: the survival and prosperity of the state. The dominance of ‘mercantilism’ as a historiographical category has obscured the role of interest in early modern thought. This paper examines the work of one of England's most prolific interest writers, Slingsby Bethel, to demonstrate the importance of reading interest writings without recourse to mercantilism. The two focuses are, first, how the rhetoric of counsel was used to defend an ordinary subject's presumption to comment on state affairs and, second, the capacity for interest writers to construe the rise and fall of state power in terms of good laws and statesmanship.     

A thought style perspective on making decisions about technology

Abstract

Continuing with the many interdisciplinary activities of Benjamin Franklin, the Institute named after him more than 150 years ago embraces today two large research centers, one scientific press, a museum and far-flung international activities, including research at the South Pole. The Institute's important pioneering activities to establish American industry and technology are recalled and emphasis is placed on the Institute's present research work.