Book Review

Gustaf Retzius (1842–1919), the Swedish anatomist and anthropologist, and Camillo Golgi were contemporaries. They met on several occasions and came in closer contact when Golgi, together with Ramón y Cajal, was awarded the Nobel Prize in Physiology or Medicine in Stockholm in 1906. Retzius came from an illustrious family. His father was professor of anatomy at Karolinska Institutet and Gustaf himself made a fast career. At 35, he was appointed to a professorship in histology, especially created for him at Karolinska Institutet, and later he became professor of anatomy in the same institution. Retzius was exceedingly productive, and published more than 300 scientific papers, most of which dealt with the nervous system and sensory organs. The majority of these were included in his magnificent volumes Biologische Untersuchungen, Neue Folge (Biological Investigations, New Series), which appeared from 1890 to 1921, and in Das Gehörorgan der Wirbelthiere (“The Acoustic Organ of Vertebrates”, 1881 and 1884), which may be his internationally better known contribution. Much of his work, especially on invertebrates, was based on Ehrlich's methylene blue method, but he also used the Golgi method early on. Particularly his studies of the innervation of the sensory organs became of great importance for the support of the neuron doctrine. His standing internationally was reflected in his membership in many of the most prominent academies abroad, as well as in invitations to him to give a “Croonian Lecture” in 1908 and “The Huxley Lecture” in 1909.     

Alexander von Humboldt: Galvanism,Animal Electricity,and Self-Experimentation Part 2: The Electric Eel,Animal Electricity,and Later Years

After extensive experimentation during the 1790s, Alexander von Humboldt remained skeptical about “animal electricity” (and metallic electricity), writing instead about an ill-defined galvanic force. With his worldview and wishing to learn more, he studied electric eels in South America just as the new century began, again using his body as a scientific instrument in many of his experiments. As had been the case in the past and for many of the same reasons, some of his findings with the electric eel (and soon after, Italian torpedoes) seemed to argue against biological electricity. But he no longer used galvanic terminology when describing his electric fish experiments. The fact that he now wrote about animal electricity rather than a different “galvanic” force owed much to Alessandro Volta, who had come forth with his “pile” (battery) for multipling the physical and perceptable effects of otherwise weak electricity in 1800, while Humboldt was deep in South America. Humboldt probably read about and saw voltaic batteries in the United States in 1804, but the time he spent with Volta in 1805 was probably more significant in his conversion from a galvanic to an electrical framework for understanding nerve and muscle physiology. Although he did not continue his animal electricity research program after this time, Humboldt retained his worldview of a unified nature and continued to believe in intrinsic animal electricity. He also served as a patron to some of the most important figures in the new field of electrophysiology (e.g., Hermann Helmholtz and Emil du Bois-Reymond), helping to take the research that he had participated in to the next level.     

Acceptance of the Neuron Theory by Clinical Neurologists of the Late-Nineteenth Century

This article explores reactions of clinical neurologists of the late-nineteenth century to the concept of a unified nerve cell, the “neuron,” which developed from the research on fine anatomy of the nervous system and from conclusions of Waldeyer based on that research. Assessment shows that Waldeyer's role in the acceptance of the neuron theory was not straightforward. A study of primarily American medical literature shows rapid acceptance, eager applications, and high expectations. Nonetheless, some clinicians were disappointed in its immediate relevance. An explanation for this disappointment is offered.     

A convenient “inconvenience”: The eponymous legacy of Sir William Richard Gowers (1845–1915)

A century since his passing, the legacy of the great Victorian clinical neurologist, Sir William Richard Gowers (1845–1915), remains traceable to students and practitioners of medicine worldwide through eponymous medical terms named in his honor. Popular designations like “Gowers’ sign” continue to lead curious minds to learn more about the pioneering neurologist’s lifework and influence, and yet Gowers himself was not fond of medical eponyms. Memorably remarking that eponyms were an educational “inconvenience” in medicine, Gowers was apt to disfavor the system in the very same lecture in which he reportedly first referred to the spinal cord fasciculus that later took his name. This article will examine Gowers’ own use of eponyms alongside the eponymous medical terms named for him, and, in the process, will show how Gowers’ “inconvenience” may be of great service to the historically inclined modern clinician today.     

The intercalatus nucleus of Staderini

Rutilio Staderini was one of the leading Italian anatomists of the twentieth century, together with some scientists, such as Giulio Chiarugi, Giovanni Vitali, and others. He was also a member of a new generation of anatomists. They had continued the tradition of the most famous Italian scientists, which started from the Renaissance up until the nineteenth century. Although he carried out important studies of neuroanatomy and comparative anatomy, as well as embryology, his name is rarely remembered by most medical historians. His name is linked to the nucleus he discovered: the Staderini nucleus or intercalated nucleus, a collection of nerve cells in the medulla oblongata located lateral to the hypoglossal nucleus. This article focuses on the biography of the neuroanatomist as well as the nucleus that carries his name and his other research, especially on comparative anatomy and embryology.     

Joseph Priestley as an heir of Newton

ABSTRACT

Like most Enlightenment philosophers, Priestley acknowledges his debt to Newton. However, despite his mentor’s prohibition against “making hypotheses”, in the 1770s, he embarked on a surprising metaphysical epic that led him, the theologian and scientist, to develop in his Disquisitions a bold system that articulated materialism, necessity and Socinianism. This synthesis constitutes the originality of a thinker who wanted to reapprehend science, metaphysics and theology together at the very moment when their dispersion seemed inevitable (and to give them an educational and political extension). It is based on a monistic ontology to which Priestley did not hesitate to give the unexpected name of materialism, at the risk of a number of misunderstandings, while he claims, much to the dismay of Reid, to closely follow the method of Newton. This paper will focus on the relation between Priestley and Newton’s ambiguous inheritance. What is Priestley’s “science” made of? What is its relationship to Newton and his “rules”, to mathematics, to the theory of language, to the so-called “analysis and synthesis method”, to Boscovich? How important is his claim for hypotheses and metaphysics? If Priestley indeed was a Newtonian, he surely was an unorthodox one.     

Michael Polanyi's Social/Political Order: Design for a Society of Explorers

Abstract

Michael Polanyi's fascinations throughout his lifetime were threefold: (1) science—specifically physical chemistry; (2) philosophy—specifically epistemology and ontology; and (3) political society, understood, in the British tradition, to include economics. In developing his recommendations for political society, Polanyi draws broadly upon insights and even concepts from his experiences and reflections in both science and philosophy. His search for meaning in all of his philosophical works provides for him the definition of what he considers the most important human endeavor and is that which the political order must strive to encourage and protect. In addition, the gratification he found in the collegiality and conviviality of scientific research, conducted most productively in what Polanyi identified as “societies of explorers,” suggested to him the diverse groups—as in science, “polycentrically” ordered—and engaged in all kinds of productive activities that came to represent, for him, the grassroots source of a society's creative vitality. Having come to appreciate the necessity of freedom for scientific discovery, freedom became a paramount value in the model he proposed for political society. But this freedom, he realized, had to operate within the boundaries of legal and moral constraint if it was not to dissolve into the oppressions of anarchy. So we find in Polanyi's model of political society a dynamic very similar to that which he had developed in his epistemology: an indwelling of tradition for the purpose of social stability but also a “breaking-out” of established ways to engage in creative endeavors. Similarly, as Polanyi had recognized higher and lower “orders” of existence in his ontology that were necessary for the “emergence” of more comprehensive and novel entities, “greater than the sum of their parts,” he provided for a similar vertical, or qualitative, “layering” in his social order. These insights, and more, that Polanyi draws from his scientific and philosophical reflections in the process of constructing his model of a political society are what I attempt to develop in this essay.     

The significance of maternalism in the evolution of fromm's social thought1

During his years as a member of the Frankfurt School, Erich Fromm developed a strong interest in the idea that there were distinctive male and female character orientations. Drawing on the positive evaluation of matriarchy made in the nineteenth century by the Swiss anthropologist J. J. Bachofen, Fromm argued that a “matricentric” psychic structure was more conducive to socialism than the patricentric structure which had predominated in capitalism. His interest in maternalism and his opposition to patriarchy played an important part in his rejection of Freud's theory of drives and in the development of a humanistic ethics in which love plays a central part. The idea of a gendered humanism is central to Fromm's social thought, although there is a danger that the over‐emphasis of sex‐based character differences unintentionally re‐opens the danger of the kind of sexual stereotyping which he resolutely opposed.     

The Neuroscience of Helmholtz and the Theories of Johannes Müller Part 1: Nerve Cell Structure,Vitalism, and the Nerve Impulse

Hermann Helmholtz made monumental contributions to the neural sciences in the second half of the nineteenth century. Among his earliest achievements were experiments that challenged vitalism, microscopic studies on the structure of the nerve cell and its processes, and the first reasonable estimates of the speed of nerve transmission based on physiological experiments. In this, the first of a two-part article, we review Helmholtz's early contributions in biographical context and with reference to Johannes Müller's own thoughts.We reveal how Johannes Müller, considered by many to be the greatest physiologist of the first half of the nineteenth century, helped to launch and shape Helmholtz's career. We also show that Helmholtz was only willing to accept some of his mentor's theories, even though he had great admiration for Müller. The point will be made that Helmholtz owed a great debt to Müller, but even from his student days in Berlin he was an independent thinker with his own agenda, and never his strict disciple.     

Hallucinations and Pathological Visual Perceptions in Maupassant's Fantastical Short Stories- A Neurological Approach

Maupassant excelled as a realist writer of the nineteenth century, with fantastical short stories being an outstanding example of his literary genius. We have analysed four of his fantastical stories from a neurological point of view. In “Le Horla,” his masterpiece, we have found nightmares, sleep paralysis, a hemianopic pattern of loss and recovery of vision, and palinopsia. In “Qui sait” and in “La main” there is also an illusory movement of the objects in the visual field, although in a dreamlike complex pattern. In “Lui,” autoscopy and hypnagogic hallucinations emerge as fantastical key elements.

The writer suffered from severe migraine and neurosyphilis involving the optic nerve, which led to his death by general paralysis of the insane (GPI). Visual loss and visual hallucinations affected the author in his last years, before a delirant state confined him to a nursing home. Our original hypothesis, which stated that he could have translated his sensorial experiences coming from this source to his works, had to be revised by analyzing some of his earliest works, notably “Le Docteur Héraclius Gloss” and “La main d’écorché” (1875). We found hallucinatory symptoms, adopting the form of autoscopy and other elaborated visual misperceptions, in stories written at age 25, when Maupassant was allegedly healthy. Therefore, we hypothesize that they may be related to his hypersensitive disposition, assuming that no pathology is necessary to experience such vivid experiences. In addition, Maupassant's abuse of drugs, as illustrated in “Rêves,” could have provided an additional element to outline his painstaking visual depictions. All these factors, in addition to his up-to-date neurological knowledge and attendance at Charcot's lectures at “La Salpêtrière,” armed the author for repetitive and enriched hallucinatory experiences, which were transferred relentlessly into his works from the beginning of his career.     

Russia,China, and the universalism of modernity: the “Account of the Reforms of Peter the Great” by Kang Youwei

ABSTRACT

This paper analyzes a short essay by Kang Youwei (1858–1927) – one of the intellectual and political protagonists of late imperial and early Republican China. In it, he interpreted the historical experience of Russian modernization under Peter the Great (1672–1725) and used it as a “success story” for the renewal of Chinese monarchical institutions. It was written in 1898 and presented to the Manchu throne under the title “Account of the Reforms of Peter the Great”, and for our purposes will be the departing point for a “global intellectual circuit” through which the following questions will be addressed: Why was seventeenth and eighteenth century Russia considered as a model for China by the author? How did he manage to adapt the historical experience of Russia into a social and political conceptual framework for China? What was Kang’s historiographical method, and what kind of philosophy of history framed his reflections? What does this short essay tell us about Kang’s view on “Westernization”, on the concept of “modernity” itself, and on its use for historiographical purposes?     

“Twitter Bodhisattva”: Ai Weiwei’s Media Politics

Abstract

This article investigates artist and activist Ai Weiwei’s media politics. In 1997 Ai Weiwei imagined a modernist movement that would practise a “non-compromising vigilance on society and power” and since 2005 he has embraced blogging and micro-blogging to enact such intent. We argue that his “communication activism” is part of a broader artistic and political program that long predates his online presence. The study examines how the artist has experimented with blogging and micro-blogging to spread his message of “awakening” in defiance of censorship and surveillance. It shows how Ai Weiwei’s communication strategy combines an international celebrity status, criticism, irony and a round-the-clock interaction with his netizen audience and the media. It also critiques the effectiveness and coherence of this mode of activism from two perspectives – namely, Jean Baudrillard’s analysis of “private telematics” and Jodi Dean’s “blog theory” – and finally assesses its impact. The study aims to enhance our understanding of the web-based communication strategies of Chinese activists, shedding light on cultural production and consumption in Chinese cyberspace as a socio-political barometer.     

Enrico Sereni: research on the nervous system of cephalopods

This essay focuses on a paradigmatic moment in neurobiological studies of invertebrates: the research on the nervous system of cephalopods carried out by Enrico Sereni at the Naples Zoological Station between 1925 and 1931. Although he remained unknown on the historiographic scenario, probably due to his early death, he contributed to Italian science of the first half of the twentieth century. In my paper particular attention will be given to Sereni's study on the pigmentary-effector, neurohumoral, and peripheral nervous systems, since they also accounted for the historical foundation of the experimental vein that, through the years, would lead John Zachary Young, Sereni's follower, to the most well-known discovery of the giant nerve fibers.     

Vincenc Alexandr Bohdálek (1801–1883): Czech anatomist and neuroscientist of the nineteenth century

Vincenc Alexandr Bohdálek (Vincenz Alexander Bochdalek) was a well-known anatomist and pathologist in the nineteenth century. Today, however, his name is all but forgotten. Bohdálek described a number of anatomical structures; some of them became eponyms. Unfortunately, his findings concerning the innervation of the eye, upper jaw, hard palate, auditory system, and meninges are little known today. This current overview is based on available archival sources and provides an insight into his results in the field of nervous system research, which account for almost half his work. Bohdálek can clearly be considered a pioneer in the field we now call functional anatomy, as he tried to find a physiological explanation for the anatomical and pathological findings he observed. The work and results of this truly outstanding neuroscientist of his time are thus again available to current and future generations of neuroscientists and neuroanatomists.     

The historical origins of the vegetative state: Received wisdom and the utility of the text

The persistent vegetative state (PVS) is one of the most iconic and misunderstood phrases in clinical neuroscience. Coined as a diagnostic category by Scottish neurosurgeon Bryan Jennett and American neurologist Fred Plum in 1972, the phrase “vegetative” first appeared in Aristotle’s treatise On the Soul (circa mid-fourth century BCE). Aristotle influenced neuroscientists of the nineteenth and early-twentieth centuries, Xavier Bichat and Walter Timme, and informed their conceptions of the vegetative nervous system. Plum credits Bichat and Timme in his use of the phrase, thus putting the ancient and modern in dialogue. In addition to exploring Aristotle’s definition of the “vegetative” in the original Greek, we put Aristotle in conversation with his contemporaries—Plato and the Hippocratics—to better apprehend theories of mind and consciousness in antiquity. Utilizing the discipline of reception studies in classics scholarship, we demonstrate the importance of etymology and historical origin when considering modern medical nosology.     

Evolution of the Concept of ‘Extracellular Matrix’ in the Brain

The question as to whether an extracellular matrix exists between cells in the adult brain has been debated since the end of the last century. In the early years, zones containing neuropil and glial processes were mistakenly believed to represent this substance. But Golgi's discovery of the “perineuronal net” paved the way for future study of the true extracellular matrix. In the 1950s, application of histochemical techniques established the existence of interstitial material between nerve cells. Unfortunately the similarity between the pericellular distribution of this material and Golgi's “pericellular nets” was overlooked. The detection of an extracellular volume fraction in the central nervous system furnished further indirect proof for the existence of an extracellular matrix in the brain. However, the repeated failure of electron microscopy to reveal a substantial space between cell processes undermined the acceptance of the concept of “extracellular matrix” in the central nervous system. Nowadays this concept has, however, been firmly established.     

Dr. Oliver Wendell Holmes on phrenology: Debunking a fad

ABSTRACT

Oliver Wendell Holmes, Sr. (1809–1894) was a Boston physician, a professor of medicine at the Harvard Medical School, and a writer of prose and poetry for general audiences. He was also one of the most famous American wits of the nineteenth century and a celebrity not bashful about exposing costly, absurd, and potentially harmful medical fads. One of his targets was phrenology, and the current article examines how he learned about phrenology during the 1830s as a medical student in Boston and Paris, and his head-reading with Lorenzo Fowler in 1858. It then turns to what he told readers of the Atlantic Monthly (in 1859) and Harvard medical students (in 1861) about phrenology being a pseudoscience and how phrenologists were duping clients. By looking at what Holmes was stating about cranioscopy and practitioners of phrenology in both humorous and more serious ways, historians can more fully appreciate the “bumpy” trajectory of one of the most significant medical and scientific fads of the nineteenth century.