Does bromide cause conversion of epilepsy to psychosis?

The aim of this study is to find out whether bromide was able to cause conversion of epilepsy to psychosis i.e., so-called paradoxical normalization such as has been seen in treatment with modern antiepileptic drugs. Spontaneous conversion has been known for three hundred years. Locock introduced bromide in the treatment of epilepsy in 1857. Belgrave wrote in 1868 on its effect on epileptic attacks and concommitant insanity. In 1868 Holm observed reduction of the frequency of seizures at the same time as psychotic symptoms or just dysphoria. In 1875 Voisin described a dose-dependent intoxication with psychosis and/or neurological signs. Stark in 1875 and Bannister in 1881 were the first to clearly describe the antagonism between epileptic seizures and psychotic symptoms, an antagonism or conversion described by many authors, both in cases with high and low dosage, and with and without intoxication. Thus, the title of this paper should be answered in the affirmative. Bromide has been used as a sedative and has rarely caused intoxication. Thus the presence of epilepsy is not a condition for the development of bromide intoxication. A case with epilepsy and fatal massive bromide intoxication is reported. It is discussed whether the pathological findings give support to Wolf's hypothesis of latent epileptic activity in subcortical pathways during "normalization".     

The Idea of Epilepsy as a Disease Per Se

In the 1850s Delasiauve and Russell Reynolds independently introduced the idea that the previously more inclusive concept of “epilepsy” should be restricted to that of an idiopathic disease manifesting epileptic seizures not caused by detectable brain pathology. This idea was rather widely accepted, though with some modification, over much of the next century. However there was increasing opposition to the idea from those, including John Hughlings Jackson, who perceived that all epileptic seizures must be symptoms of underlying brain disease. With increasing identification of structural brain pathology in what had been regarded as instances of idiopathic epilepsy, the latter view has increasingly prevailed.     

On morel's épilepsie larvee: The first Danish epileptologist Frederik hallager's opposition in 1884 against morel's psychical epileptic Equivalents*

Abstract

In 1860 B.A. Morel published some cases of masked epilepsy, i.e., paroxysmal behaviour disturbances or “epileptic equivalents”;. The majority behaved criminally. Hughlings Jackson opposed and Hallager showed that all the cases related later as épilepsie larvée could be explained as postepileptic attacks, general paralysis, paradoxical normalization, schizophrenia, mania and otherwise. True criminal behaviour was exeptional. The present author agreed. There is no need for épilepsie larvée. It is discussed whether Blumer's recent “Paroxystic neurobehaviour disorder”; will revive “Morel's disorder”;.     

Ancient Indian concepts about phenomenology,biology, and therapeutics of epilepsy

This article discusses etiology, pathogenesis, symptoms, and treatment of epilepsy, as described in Charaka Samhitā (translation: Charaka’s Compendium) and Sushruta Samhitā, the two core texts of Ayurveda, an ancient system of medicine. Ayurveda emphasized amnesia and loss of consciousness as core features of epileptic seizures (Sanskrit: apasmar; translation: apa negation, smaran memory) and recognized that seizures occur due to a disturbance in brain function or flow of “humors” to the brain. Semiology of various seizure types was well described. Epilepsy was attributed to both internal and multiple exogenous factors. Treatment of epilepsy with formulations of naturally occurring substances, their compounding and use, is described in remarkable detail. Lifestyle modifications to protect people with epilepsy are also documented. Cognitive comorbidities of epilepsy were recognized. Although none of the Ayurveda formulations have any empirical evidence supporting their safety or efficacy in the treatment of epilepsy, studies are needed to generate relevant evidence, to recognize their hazards, and to integrate traditional and complementary systems of medicine with modern health care in an informed and safe manner.     

Neurology and Literature, 1860–1920 by Anne Stiles (ed.)

Abstract

Research from many perspectives has been made on the work of the French neurologist, J.‐M. Charcot (1825–1893) with particular reference to his fame for his studies and “construction”; of hysteria. What has not been demonstrated so far is the extent to which Charcot's construction can be explained by the perceived relationship between hysteria and epilepsy and Charcot's access to epileptic patients at La Salpêtrière. From the confusion that reigned concerning hysteria and epilepsy, both separately and in relation to each other, Charcot claimed to have isolated hysteria as a distinctive and universal pathology. This claim was partly based on the “grande attaque”;, representing the most intense degree of hysteria. A comparison with Gowers, the contemporary English neurologist suggests that diagnosis was the function of the practitioners’ preferences; and a linguistic analysis pinpoints Charcot's problems in describing an isolated pathology in terms of its relation to its neighbour, epilepsy.     

Albert the Great's interpretation of neuropsychiatric symptoms in the context of scholastic psychology and physiology* 1

Abstract

Albert the Great (ca. 1193–1280) serves as an example to show how the Latin West successfully integrated Greco‐Arabian psychology with Galenic physiology. He divised a model of perceptive, cognitive and mnestic powers located in different areas of the “brain cells”; and interacting with the immaterial and man‐specific intellect. He managed to describe anmesis, epileptic seizures and psychotic states as results of disturbed brain fuction. Finally, further aspects of Scholastic theorizing on mental disorders are discussed.     

Measuring cost escalation in the formative era of U.S. higher education, 1875–1930

ABSTRACT

Cost escalation in higher education in the United States prior to 1930 has scarcely been studied, even though the period from the 1870s to the 1920s was formative for U.S. higher education. This article develops and explains a method to measure the cost during this period. The authors then compile more accurate cost data than have been available, calculate new cost indexes for higher education from 1875 to 1930, and compare these indexes to economy-wide indexes. The striking findings inform the two leading economic theories of cost escalation, advanced by economists Howard R. Bowen and William G. Bowen. Cost escalation in total expenses of higher education occurred consistently between 1875 and 1930, and exceeded the worrisome rate that economist Howard Bowen found for the period from 1930 to 1977. Cost escalation did not occur in the more salient per capita terms. This latter finding, combined with recent historical research, supports the “revenue theory of cost” of Howard Bowen and challenges the “cost disease theory” of William Bowen.     

Ships on Maps: Pictures of Power in Renaissance Europe. By Richard W. Unger

Abstract

In the Reclus-Perron cartographical collection held in the Public Library of Geneva, a recently discovered map by the explorer Henri Coudreau seems to have been essential, together with other published and unpublished cartographic materials, in deciding the 1900 Swiss arbitration of the Franco-Brazilian border dispute. These materials provide an opportunity not only to analyse the political power of maps, but also to explore a different European way of conceiving maps and geography, that of anarchist geographers, which diverged from the uncritical hagiographies of colonialism and geographical discoveries that were typical in European science during the Age of Empire (1875?1914).     

The Industrial Heritage in Japan

Abstract

Although Japan had begun to learn Western technology from the mid-sixteenth century, it was immediately before the Meiji Restoration in 1868 that the imminent necessity of industrialization was realized by a few farsighted leaders of some feudal clans. Thereafter, her industrialization made rapid progress down to the time of World War II, when much industrial equipment was lost in the massive air-raids.

The loss of her pre-war plants was further aggravated by the extensive renewal of old-fashioned buildings and machines, carried out during the period of her economic growth in the 1960s. This paper attemps to describe how the surviving industrial monuments from several representative sections of industry are preserved either on site or in museums, and how their study has recently been taken up in Japan.     

Jean-Martin Charcot and the epilepsy/hysteria relationship

Research from many perspectives has been made on the work of the French neurologist, J.-M. Charcot (1825-1893) with particular reference to his fame for his studies and "construction" of hysteria. What has not been demonstrated so far is the extent to which Charcot's construction can be explained by the perceived relationship between hysteria and epilepsy and Charcot's access to epileptic patients at La Salpêtrière. From the confusion that reigned concerning hysteria and epilepsy, both separately and in relation to each other, Charcot claimed to have isolated hysteria as a distinctive and universal pathology. This claim was partly based on the "grande attaque", representing the most intense degree of hysteria. A comparison with Gowers, the contemporary English neurologist suggests that diagnosis was the function of the practitioners' preferences; and a linguistic analysis pinpoints Charcot's problems in describing an isolated pathology in terms of its relation to its neighbour, epilepsy.     

William Rutherford Sanders (1828–1881) and his neurologically fertile years (1865–1868)

ABSTRACT

William Rutherford Sanders (1828–1881) was an Edinburgh physician who occupied the Chair of Pathology at the University of Edinburgh from 1869 to 1881. All of his published output between 1865 and 1868 was concerned with neurology. In arguing that a patient did not have paralysis agitans, Sanders (1865) employed the term “Parkinson’s disease” for the first time in the English-language literature to distinguish between the disorder that Parkinson (1817) termed “paralysis agitans” and other types of shaking palsies. He contributed a major chapter on the same topic to Russell Reynolds’s A System of Medicine (1868). Sanders also investigated the innervation of the palate and facial muscles (1865), and in 1866 recorded the autopsy findings in two cases of aphasia. Here, for the first time in the English-language literature, he described findings that supported Broca’s location of the representation of speech to a particular area of the left cerebral hemisphere.     

The discovery of anti-epileptic drugs

The general history of epilepsy is well documented, there being detailed accounts from ancient times in Babylonia (Wilson et al., 1990), ancient India (Bharucha & Bharucha, 1989), and China (Lai & Lai, 1991), up until the end of the 19th century (Tempkin, 1971). But relatively little has been written about its medical treatment, (Melville, 1982). The subject of this article is the history of potassium bromide, phenobarbitone and phenytoin, how their use in epilepsy was discovered, and in particular the surprisingly large part played by chance, luck and serendipity, in their introduction to the pharmacopaeia. The advance in this field has been one of sudden leaps forward, followed by periods of apparent inactivity, until the next discovery emerged, a pattern repeated many times, since medical treatment of epilepsy began with potassium bromide in 1857, until the introduction of vigabatrin in 1990.     

THE ROLT MEMORIAL LECTURE 2011

Abstract

The Pawtucket Dam in Lowell is a key site in the interpretation of the city’s industrial heritage and a potent symbol of corporate determination to alter the natural environment for textile production and profit. It is both a certified National Landmark and the most dramatic feature of a National Park, the first one to be located in an American industrial city. Without a great dam at Pawtucket Falls, Lowell would never have become a renowned example of manufacturing prowess and attractive urban design. Every dam built across the Merrimack River since 1825 at that site has been controversial. They have blocked fish migrations, overflowed farmland, backed water into the wheelpits of upstream mills, halted log drives, and made floods more destructive. The existing Pawtucket Dam of 1847 and 1875 is now the focus of a heated debate between preservationists and a hydroelectric power company that wants to alter it.     

‘On mind‐blindness (optic agnosia)’, a classical clinico‐pathological report,and its author Wilhelm von Stauffenberg (1879–1918)*

Abstract

Two photographs from the beginning of our century still instructively illustrate the phenomenon of visual agnosia: the perplexed face of an old lady confronted with objects clears after touching them. This patient with bilateral posterior cerebral infarction was followed for seven years at the Munich Medicine Department of Friedrich von Müller (1858–1941) who had a strong interest in neurology. His assistant Wilhelm von Stauffenberg (1879–1918) reported the case in great detail, including anatomical analysis performed under Constantin von Monakow (1853–1930). Promoted to “Privatdozent”; in 1913 on the basis of this report, Stauffenberg's work included several additional, similarly extensive clinico‐anatomical case studies but was not limited to problems of cerebral localisation. Under the influence of the Burghölzli group in Zürich he started to practice psychotherapy. Stauffenberg, deeply interested also in the arts and in literature, was the physician of the poet Rainer Maria Rilke (1875–1926) from 1914. He succumbed to pneumonia in 1918.