The first record of palaeopathology from the zooarchaeological record of late Pleistocene,southwest Tasmania

Several bones from the Late Pleistocene archaeological site, Kutikina Cave, in southwest Tasmania, show pathological conditions. The majority of these specimens represent Bennett's or red‐necked wallaby (Macropus rufogriseus), with a single specimen of the Common wombat (Vombatus ursinus) recorded. While there has been extensive work in this region of Australia since the early 1980s, this is the first record of palaeopathology from the late Pleistocene of Tasmania, and the first from a human accumulation of predominately macropod material. The palaeopathology raises several questions concerning the mobility of these animals which might have increased their susceptibly to predation, while some of the effected elements are fragmented, suggesting that people utilised these bones despite their deformities. Copyright © 2008 John Wiley & Sons, Ltd.     

Microscopical findings associated with the diagnosis of osteoporosis in palaeopathology

This paper presents some preliminary results on microscopical identification of microfractures in human skeletal remains which may be associated with osteoporosis. A technique is described for the examination of cancellous bone and applied to a number of vertebrae and one radius. All the material used is Romano-British or English medieval. However, microscopical screening for osteoporosis could form a useful part of comparative studies on historically or geographically different populations. The archaeological significance of osteoporosis in terms of skeletal ageing and nutritional status is discussed.     

The limits of biomolecular palaeopathology: ancient DNA cannot be used to study venereal syphilis

To determine whether ancient DNA (aDNA) can be used to study the palaeopathology of venereal syphilis, we carried out a comprehensive analysis of the preservation of human and pathogen DNA in a set of 46 bones of various ages, most of which displayed osteological indications of the disease. Bones came from seven English cemetery sites that were in use during the 9th–19th centuries. Twelve of the 46 bones consistently yielded mitochondrial DNA (mtDNA) sequences after replicate polymerase chain reactions (PCRs), and a further 13 bones yielded mtDNA sequences with less reproducibility. The sequence data enabled tentative mitochondrial haplogroups to be assigned to nine of the bones, and the identities and frequencies of these haplogroups were compatible with the geographical origins of the bones. Twenty-one bones consistently gave negative results with all mtDNA PCRs, indicating that at least these bones were not contaminated with modern human DNA, and those bones that gave positive results only yielded one sequence each, again suggesting that widespread modern contamination had not occurred. Mycobacterium tuberculosis sequences were obtained from seven bones, including three of five bones with tuberculous lesions. The cloned and direct sequences obtained from both the mtDNA and M. tuberculosis PCR products showed features typical of degraded aDNA. All of these results suggest that at least some of the 46 bones that we studied were suitable for aDNA analysis. All 46 bones were tested with nine different treponemal PCRs, each optimised to give a detection limit of ≤5 genomes. Although various bones gave PCR products of the expected size with one or more of these PCRs, sequencing showed that none of these products were authentic treponemal amplicons. Our failure to detect treponemal DNA in bones that were suitable for aDNA analysis, using highly sensitive PCRs, suggests that treponemal DNA is not preserved in human bone and that it is therefore not possible to use aDNA analysis to study venereal syphilis. Any past or future paper claiming detection of treponemal aDNA should therefore be accompanied by a detailed justification of the results.     

Pathogenesis of apical periodontal cysts: guidelines for diagnosis in palaeopathology

Apical periodontal cysts are benign lesions developing in relation to the apices of non‐vital teeth due to inflammatory response from the infective pulp. These are epithelium‐lined bony cavities containing fluid. Despite being widely reported in medical/dental literature, this common condition is poorly diagnosed and documented in the archaeological literature. We aim to clarify the correct terminology, demonstrate bony manifestations at different stages of pathogenesis of chronic periapical dental lesions into granuloma and apical periodontal cysts, and to describe diagnostic criteria which would provide practical guidelines for the diagnosis of these conditions. Three identified skulls from the International Exchange Collection, housed in the Anthropological Museum at the University of Coimbra, are used to identify the progression of this condition from a small periapical granuloma to a large apical periodontal cyst with expansion of alveolar and facial bones. The pathogenesis of this condition is described, together with its surgical management in the early 20^th century in Portugal, which is the period in which these individuals lived. Confusion resulting from the different terminologies can be avoided if the term periapical granuloma is used to define apical bony lesions smaller than 3 mm at their maximum intra‐bony diameter, and the term apical periodontal cysts for the larger lesions. We recommend that these terminologies and parameters be used as a standard in future studies. This will make inter‐observer and inter‐population comparisons more accurate. Copyright © 2007 John Wiley & Sons, Ltd.     

Rates for the job. Measures of disease frequency in palaeopathology

Measures of disease frequency are discussed and their use in palaeopathology illustrated with examples, both hypothetical and real. It is shown that prevalence rates are the appropriate rates to use when calculating the frequency of diseases in skeletal populations. The extent to which prevalence rates accurately reflect those in the living population from which the skeletons were derived is also considered and it is suggested that they are a reasonable approximation for diseases that do not shorten life span, but not for those that do. Finally, suggestions are made for dealing with missing data.     

On problems of differential diagnosis in palaeopathology,as illustrated by a case from prehistoric Indiana

Because palaeopathology has to call on a limited range of evidence, compared with modern clinical diagnosis, it is important that a differential diagnosis should be broad‐based. A prehistoric case from Indiana is discussed in relation to this statement. Copyright © 2009 John Wiley & Sons, Ltd.     

Trace elements in palaeopathology: Quantitative analysis of a case of hypertrophic osteoarthropathy by instrumental neutron activation analysis

Instrumental neutron activation analysis (INAA) of the bones of a 6th century case (AD ) of hypertrophic osteoarthropathy (HOA) showed high levels of Zn, Mn and K in the periosteal new bone. The concentration of Zn in the periosteal new bone appeared to be biogenetic in origin and connected with active mineralization processes in the abnormal bone tissue. Manganese and potassium concentrations were, at least partly, related to diagenetic processes.     

Life on horseback: palaeopathology of two Scythian skeletons from Alexandropol,Ukraine

In 2006, two skeletons were analysed that were previously excavated from the periphery of a Scythian burial mound, near the village of Alexandropol in southern Ukraine. Dated to ca. 325 BC, both remains are male. The first is that of a youth in his late teens who exhibits indications of biological stress and degenerative changes to the spine in the form of a Schmorl's node. The second is a middle‐aged individual with extensive healed lesions due to trauma to the right humerus and clavicle with associated bony changes of the elbow and spine. Stable isotope analyses indicate a diet based on C3 plants. Their skeletons suggest a rigorous life on horseback. Both may have served as sacrificial victims. Historical records document the strangulation of attendants and their placement around the periphery of royal burial mounds. Grave goods suggest that both were warriors, although the youth lacks the traumatic injuries exhibited by the older male. The individuals from Alexandropol may have served a Scythian king in life and in death. Copyright © 2008 John Wiley & Sons, Ltd.     

High performance liquid chromatography (HPLC) in the investigation of gout in palaeopathology

Gout is a disease caused by the abnormal accumulation of uric acid in the body, which can result in sodium urate crystals forming tophi at joints, with associated erosion of bone and cartilage. Only two examples of tophi have been reported from archaeological individuals, and the diagnosis of gout based on dry bone manifestations can be difficult. This paper presents preliminary results of a new technique to aid the diagnosis of gout in palaeopathology, namely high performance liquid chromatography (HPLC). Five archaeological skeletons with suspected gout (diagnosed using visual and radiological analysis) and three controls were analysed. Two of the gouty individuals had a white powder in their erosive lesions. HPLC showed the presence of uric acid in bone in four of the five individuals with evidence of gouty arthritis and was negative for uric acid in bone from the three controls. The white powder was also positive for uric acid. With reliance on the presence of articular erosions, cases of gout will be missed in archaeological human bone. HPLC measurement of uric acid could prove useful in the differential diagnosis of erosive arthropathy in archaeology. It may also be useful in identifying individuals with an increased body pool of uric acid, linked to conditions included in the term ‘metabolic syndrome’. As a result, HPLC uric acid measurement also has the potential to provide additional information on health and lifestyle in past communities. Copyright © 2008 John Wiley & Sons, Ltd.     

Using ancient DNA analysis in palaeopathology: a critical analysis of published papers,with recommendations for future work

Despite an observable increase in the number of studies using ancient DNA analysis to diagnose disease in human remains, there remain issues to be addressed about the quality of the resulting publications. This paper describes the qualitative analysis of published papers that describe the detection of pathogenic DNA in human skeletal and mummified remains from archaeological sites. Its ultimate goal is to provide an overview of the main problematic issues in relationship to standards developed in molecular biology and to make recommendations for future work. Sixty‐five papers published between 1993 and 2006 were surveyed and the quality of each was assessed using 15 criteria. Interesting results emerged. Of particular note was the high number of papers that did not acknowledge the use of even basic contamination control (90%) or procedures to validate results independently (85%). This study illustrates that attention to contamination control and authentication of results is needed in future research, if confidence in aDNA analysis in palaeopathology is to be increased. Additionally, methods of analysis must be described in published papers to ensure transparency in processes utilised to generate the data. Copyright © 2008 John Wiley & Sons, Ltd.     

指纹元素分析对南宋郊坛官窑的起源研究

选取30个南宋官瓷样品、2个效坛官窑的原料、紫金土和4个现代仿官瓷样品进行中子活化分析（NAA）,测定每个样品中36种微量元素的含量。从这36种元素中挑选出9种指纹元素的含量进行散布分析。结果表明：南宋官窑的釉料和胎料产地明显不同;南宋官窑有着长期稳定的釉料和胎料产地;遗址缸内的原料（35#）、练泥池内的原料（36#）、紫金土（37#）既不同于古官瓷的釉料,也不同于胎料。练泥地内的原料（36#）比较接近于胎料。现代官瓷的釉料和胎料与古官瓷的明显不同,说明它们的产地不同。     

A foot deformity from a Romano‐British cemetery at Gloucester,England, and the current evidence for talipes in palaeopathology

A male skeleton from the Romano‐British site at Kingsholm, Gloucester, is described with abnormalities in the humerus, femur, tibia, fibula and foot. Computed tomography of the femora to enable cross‐sectional analysis suggested altered normal gait to compensate for the deformity. Differential diagnoses are considered and a diagnosis of clubfoot deformity is suggested. Palaeopathological evidence for clubfoot is rare in the literature but the cases reported to date are reviewed. Copyright © 2004 John Wiley & Sons, Ltd.     

Monitoring Cultural Heritage in a Long-Term Project: The Norwegian Sequential Monitoring Programme

Abstract

A sequential monitoring programme for archaeological sites and monuments was started in Norway in 1997. The purpose of this ongoing monitoring was to produce more accurate figures for loss and damage and to detect long-term trends in loss/damage patterns. In this article we present the method used to document the sequential monitoring, the extent of and the most important causes of loss and damage to archaeological heritage, and we discuss both the strengths and weaknesses of the method used in this monitoring programme. The results so far point to agriculture as the single most important cause of loss, and together with housing and leisure it is also the most important cause of damage. In the large parts of Norway where agriculture is marginal and has been characterized by small farms and grass based livestock production, regrowth of fallow fields leads to cultural landscape change and the loss of archaeological sites.     

State‐of–the–art imaging in palaeopathology: the value of multislice computed tomography in visualizing doubtful cranial lesions

Non‐invasive imaging techniques are of great value in palaeopathology. Computed tomography (CT) is widely established to visualize changes in human remains that occurred both pre and post mortem. Since 1999 an advanced form of helical CT—so called Multislice‐CT (MSCT)—has become available for clinical purposes. We now present for the first time three historic cranial lesions of doubtful aetiology visualized by MSCT. Both original images and virtual reconstructions of the specimens are of high quality. In combination with peri‐lesional bone density measurements these images allow an improved assessment of aetiology. The cases presented are diagnosed by MSCT as being of intra vitam nature in two individuals and of post mortem character in one case. Time consuming post‐processing analysis and the still small number of scanners presently available may limit application of this new technique. Nevertheless, based on our preliminary results, we strongly recommend non‐invasive evaluation by MSCT to be used for non‐clinical purposes such as palaeopathological research. Copyright © 2002 John Wiley & Sons, Ltd.     

独辟蹊径为创匠——辽宁省博物馆藏高其佩指画《怒容钟馗图》

我国绘画艺术博大深邃,源远流长,每个时代的画风和画家们的独特风格,有如万舸争流,奔腾不息。传统的中国绘画,大多以毛笔作为主要的使用工具。人们基于对独特艺术风格的潜在追求,不断探索用新的表现手段来体现对艺术的感受。清代康熙、雍正年间辽宁铁岭籍画家高其佩在绘画艺术领域师传统、     

Nonlinear Structural Performance of a Historical Brick Masonry Inverted Dome

ABSTRACT

Traditional domes are obtained by double curvature shells, which can be rotationally formed by any curved geometrical plane figure rotating about a central vertical axis. They are self-supported and stabilized by the force of gravity acting on their weight to hold them in compression. However, the behavior of inverted domes is different since the dome is downward and masonry inverted domes and their structural behaviors in the literature received limited attention. This article presents a nonlinear finite element analysis of historical brick masonry inverted domes under static and seismic loads. The brick masonry inverted dome in the tomb of scholar Ahmed-El Cezeri, town of Cizre, Turkey, constructed in 1508 is selected as an application. First, a detailed literature review on the masonry domes is given and the selected inverted dome is described briefly. 3D solid and continuum finite element models of the inverted masonry dome are obtained from the surveys. An isotropic Concrete Damage Plasticity (CDP) material model adjusted to masonry structures with the same tensile strength assumed along the parallel and meridian directions of the inverted dome is considered. The nonlinear static analyses and a parametric study by changing the mechanical properties of the brick unit of the inverted masonry dome are performed under gravity loads. The acceleration records of vertical and horizontal components of May 1, 2003 Bingöl earthquake (Mw = 6.4), Turkey, occurred near the region, are chosen for the nonlinear seismic analyses. Nonlinear step by step seismic analyses of the inverted dome are implemented under the vertical and horizontal components of the earthquake, separately. Static modal and seismic responses of the inverted masonry dome are evaluated using mode shapes, minimum and maximum principal strains and stresses, and damage propagations.     

The inclusion record of fluid evolution,crack healing and trapping from a heterogeneous system during rapid cooling of pegmatitic veins (Dronning Maud Land; Antarctica)

Granitoid (pegmatite and aplite) veins in metamorphic rocks and intrusive syenites of central Dronning Maud Land, Antarctica, are flanked by conspicuous light‐coloured alteration halos, which represent the damage zone of fracture propagation. The damage zone is characterized by a high density of sealed or healed microcracks, about 1 order of magnitude above background. Fluid inclusions along healed microcracks in quartz of both pegmatite and alteration halos are inspected by optical and scanning electron microscopy, and their composition is analysed by microthermometry and quadrupole mass spectrometry. The similar inclusion record in the granitoid vein and in the damaged host rock indicates the derivation of the fluids from the hydrous melt phase. The aqueous inclusions bear abundant daughter crystals, mainly silicates, and may represent a hydrous melt. The volatile composition is variable in the system H₂O–CO₂, with mostly subordinate amounts of N₂. Phase separation with partitioning of CO₂ into the fluid phase coexisting with the hydrous melt, and possibly immiscibility in the subsolidus range, govern fluid evolution during cooling. The variable CO₂/N₂ ratio suggests mixing with fluids from an external source in the host rock and vigorous circulation at an early stage of high transient permeability. Experiments have shown that healing of microcracks at high temperatures is a matter of hours to weeks, hence similar in time scale to the cooling of the cm‐ to dm‐thick granitoid veins. In this case, rapid cooling and concomitant crack healing in a system undergoing phase separation causes a broad compositional variability of the inclusions due to necking down, and the underpressure developing in closed compartments precludes a meaningful thermobarometric interpretation.