Approaches in Post-Experimental Science. The Case of Precision Medicine**

In the introduction to his Spalt und Fuge, Hans-Jörg Rheinberger points to the possibility that we are currently experiencing a new turning point regarding forms of experimentation, which is characterized by the growing importance of high-throughput methods and big data analytics. This essay will explore the thesis that data-intensive research indeed constitutes a form of post-experimental research by interrogating research practices in precision medicine. Section 1 will introduce this thesis and highlight salient features of precision medicine as an example of post-experimental research. Section 2 suggests approach as a category that is broader than experimental system, as discussed by Rheinberger, and can serve to analyze and compare diverse forms of research, including experimental and post-experimental practices. The essay concludes with a reflection on how categories developed for the historiography of recent science might require an update when the science or its context changes (section 3).     

Creativity and its contexts: the emergence,institutionalisation and professionalisation of science and culture in Luxembourg

While an abundant literature on the social history of culture and science in Europe has developed over the past few decades, there is to date hardly any academic work exploring the social history of science and culture in Luxembourg. The aim of this article is to put Luxembourg ‘on the map’ by focusing on its scientific research and museums in order to examine the emergence, institutionalisation and professionalisation of Luxembourg's science and culture. It will be argued that the most radical changes occurred in the 1980s and 1990s: a multiplication of infrastructures, an increase in budgets, a professionalisation of practices, the emergence of a market for artworks, and an appearance of dedicated policies. During this period, both the material architecture and the socioeconomic architecture of science and culture have been significantly (re)configured. Within the political debates accompanying these changes, the discourses stressing the positionality and relationality of science and culture are noteworthy: while both were increasingly positioned within a European context, research was predominantly portrayed as a resource to boost Luxembourg's economy whereas culture more as a complement to Luxembourg's image of a financial player and a means to ‘regenerate’ its symbolic capital.     

An experimental ethnoarchaeological approach to understanding the development of use wear associated with the processing of river cane for split-cane technology

Southeastern Indians have been using cane (Arundinaria spp.) for basketry and matting for thousands of years. Unfortunately, it is only under extraordinary preservation conditions that such items survive archaeologically. Inferring the production of split-cane technology requires an understanding of prehistoric manufacturing and processing techniques. It is hypothesized that stone tools were once used to process cane for use in split-cane technologies. In the Southeast, it is not uncommon to find stone tools with traces of plant use; however attributing wear to specific plants has been problematic. Pilot experiments, grounded on ethnoarchaeological observations, were conducted with river cane (Arundinaria gigantea) in collaboration with expert basket weavers in the Cherokee Nation. The experimental ethnoarchaeological program was designed to test the efficiency of stone tools in cane processing and document use wear through microscopic observations. The results found that non-retouched flakes were efficient for processing river cane and that the different stages of splint preparation resulted in the differential development of use-related wear. Additional experimentation with river cane is necessary to better define use wear and establish criteria for identification in archaeological contexts. Nonetheless, the collaborative and experimental approach undertaken demonstrated the utility of combining traditional archaeological methods with experimentation, ethnoarchaeology, and tribal knowledge.     

The search for historical experience

In the first part of my paper I will try to reconstruct a series of attempts at dialogue between history and the social sciences made by historians connected with the “Annales” (Marc Bloch, Ernest Labrousse, Giovanni Levi, Bernard Lepetit). What these attempts have in common is the idea that in history, as in the natural sciences, it is to some extent possible to carry out forms of experimentation on the sources, and that the inclusion of history among the human sciences, and even the scientific future of the discipline itself, ultimately depend on the adoption of this method. In the second part I will discuss the relationship that links historical experimentation with lived experience, and I will conclude by discussing the possible meaning of the idea of experimenting with the sources of history.     

Wissenschaft im Gehäuse: Vom Nutzen und Nachteil institutionengeschichtlicher Perspektiven

Research is realized in social and cultural context, it is established in institutions, as far as different forms and conditions of practice are concerned. In this article some German examples demonstrate how flexible and varied the institutions of research can be during the course of history of science. The first part deals with historically grown, yet chronologically overlapping institutions of research: beginning with the lonely scholar, going on to hierarchally organized big science and ending up with virtual institutions. In the second part, at the intersection of political‐social administration and styles of scientific thought terms like German Realpolitik, science in context, and science policy are discussed within the modernization process.     

Cultural fingerprints – the legacy of cultural values in the current cultural policy agenda in Germany

This paper explores the historical roots of cultural values as a prerequisite for German cultural policy. With reference to current investigations of the social impact of the arts, the analysis is based within the framework of the history of ideas and focuses on three concepts: the common base of culture, nation of culture and culture as a state aim. The author argues that the transformative positive powers of culture are linked in a complex system of historically grown intellectual alliances while directing current policy thinking. As a consequence the positive impact of culture in society is strengthened over time and remains unquestioned by actors in the cultural sector.     

Clarifying the critical in critical heritage studies

This paper considers the term critical in the unfolding formulation of critical heritage studies. It argues for a shift in emphasis from the subject of our effort to the object of attention, in other words focusing primarily on the critical issues that face the world today, the larger issues that bear upon and extend outwards from heritage. To that end, the paper presents two key directions. It suggests much is to be gained from tackling the uneasy relationship that currently exists between social science and humanities-based approaches to heritage and the professional conservation sector oriented by a scientistic materialism. Second, there is a need for heritage studies to account for its relationship to today’s regional and global transformations by developing post-western understandings of culture, history and heritage and the socio-political forces that actualise them.     

HISTORY,ANTHROPOLOGY, COLONIALISM,AND THE STUDY OF INDIA

Autobiography of an Archive is a collection of essays by Nicholas B. Dirks written since 1991, preceded by an autobiographical introduction. This review article discusses the collection in relation to Dirks's overall scholarship and the wider intellectual field in which history, anthropology, and colonialism intersect in the study of India. Dirks has written three books: The Hollow Crown (1987), an “ethnohistory” of a “little kingdom” in south India; Castes of Mind (2001), about colonialism, anthropology, and caste in India; and The Scandal of Empire (2006), which discusses the foundations of British imperial sovereignty. In The Hollow Crown and other writings, Dirks significantly contributed to the debate about the “rapprochement” between anthropology and history, which was prominent in the 1980s. But in the 1990s, Dirks thought, the rapprochement ground to a halt; the relationship between anthropology and colonialism then came to the fore, and Castes of Mind, as well as some of these essays, were influential critical studies of colonial anthropology. In recent essays, Dirks has examined the “politics of knowledge” and the postwar development of South Asian area studies in the United States. This article argues that although the relationship between anthropology and history is now rarely debated, historical anthropology has continued to develop since the 1980s. Moreover, anthropologists in general now recognize that history matters, and that colonialism crucially shaped modern society and culture in India, and other former colonial territories. Many of Dirks's conclusions about, for example, Indian kingdoms and caste in colonial discourse, have been criticized by other scholars. Nonetheless, anthropological writing, especially on India, is no longer unhistorical, as it once often was, and Dirks's scholarship has played a valuable part in bringing about this change.     

The "Trial" of Lee Benson: Communism, White Chauvinism, and The Foundations of the "New Political History" in the United States

Lee Benson was one of the first American political historians to suggest a “systematic” revision of traditional political history with its emphasis on narrow economic class analysis, narrative arguments, and over‐reliance on qualitative research methodologies. This essay presents Benson's contributions to the “new political history”—an attempt to apply social‐science methods, concepts, and theories to American political history—as a social, cultural, and political narrative of Cold War‐era American history. Benson belonged to a generation of ex‐Communist American historians and political scientists whose scholarship and intellectual projects flowed—in part—out of Marxist social and political debates, agendas, and paradigmatic frameworks, even as they rejected and revised them. The main focus of the essay is the genesis of Benson's pioneering study of nineteenth‐century New York state political culture, The Concept of Jacksonian Democracy, with its emphasis on intra‐class versus inter‐class conflict, sensitivity to ethnocultural determinants of political and social behavior, and reliance on explicit social‐science theory and methodology. In what follows, I argue that The Concept of Jacksonian Democracy has its roots in Benson's Popular Front Marxist beliefs, and his decade‐long engagement and subsequent disenchantment with American left‐wing politics. Benson's growing alienation from Progressive historical paradigms and traditional Marxist analysis, and his attempts to formulate a neo‐Marxism attentive to unique American class and political realities, are linked to his involvement with 1940s radical factional politics and his disturbing encounter with internal Communist party racial and ideological tensions in the late 1940s at Cornell University in Ithaca, New York.     

Wissens‐ und Wissenschaftstransfer – Einführende Bemerkungen

Knowledge and science transfer – introductory remarks. The article presents introductory remarks on the historical study of knowledge and science transfer. Discussion focuses initially on the reasons for speaking of knowledge transfer and not only about science transfer, and the relations of this topic to current research in general history on cultural transfer. Multiple levels of knowledge / science transfer are then discussed, specifically: (1) transfer by means of migration or other movement of people across geographic boundaries; (2) scientific changes related to the transfer of objects (such as plant specimens or instruments) across continents or disciplines; (3) knowledge or science transfer in practical contexts. Addressed throughout is the problematic character of the concept of transfer itself. The author suggests that users of this concept often presuppose a static conception of scientific and cultural contents being more or less successfully transferred; more interesting, however, are the changes in science and culture conditioned or caused by the migration of individuals as well as the transfer of culture by other means.     

Hans-Jörg Rheinberger as a Philosopher of Time**

When Hans-Jörg Rheinberger proposed the concept of epistemic things, he drew inspiration from the art historian George Kubler, who had considered the aesthetic object as resulting from problem-solving processes in The Shape of Time (1962). Kubler also demonstrated that a sequence of objects could retrace the progress that led to a solution that was afterwards accepted as the most classical. Parallel to Kubler, Rheinberger demonstrates how temporally extended activities of experimentation are condensed in the object, revealing the moments of innovation that lead to it. In the history of science as well as in art history, various trajectories can thus be grasped in the materially given. Rheinberger conceives of an object as a network of heterogeneous time strings. However, these are manifold: they cannot be thought of as making up a homogeneous temporality encompassing all the others as a temporal container and synchronizing them within it. Since the discovery of the Anthropocene, we no longer separate natural from cultural time, and no hegemonic historical narrative can be taken as unifying all the others. Historical epistemology as proposed by Rheinberger will be read as a contribution to constructing new models of natural as well as of cultural time.     

Showing and telling science – the integrated use of literature and images in the works of Erasmus Darwin and Alexander von Humboldt

ABSTRACT

In recent years, both the fields of literature and science and visual culture of science have addressed the importance of different visual and literary elements and their roles in establishing meaning and communication in science. In this article, I explore how visual and textual elements work to establish a narrative of plants in Erasmus Darwin’s The Botanic Garden (1791) and in Alexander von Humboldt’s Essai sur la géographie des plantes (1804). These two scientists employed literary and visual elements in order to construct their visions of the nature of plants in a time when the ideals of Enlightenment science gave way to a more holistic view of integrating the sciences and the arts. I, therefore, also discuss the analytical approach of integrated readings between the literary and visual elements of science.     

OBJECTS OF HISTORY: THE PAST MATERIALIZED1

What is the role of material culture in understanding the past? This review essay explores two principal approaches—the history of museums and antiquities and environmental history—to reflect on their shared investment in historical materialism. It reviews Timothy LeCain's The Matter of History and Peter Miller's History and Its Objects, discussing their perspectives on objects and the writing of history. One important part of this history concerns the relationship of academic historians to the idea of a history museum, curatorial practices, and public history. What kinds of history can we do in a museum, with things, that might not occur without the presence of objects? Why were nineteenth- and early twentieth-century efforts to encourage a close relationship between historical research and the history museum largely abandoned in favor of a document-driven approach? The second dimension of current interest in historical materialism concerns new approaches to environmental history. It draws inspiration from Deep History as well as recent work in archaeology and STS (Science and Technology Studies) to argue for a more integrated history of humans and nature that demonstrates how things have made us. The history of successive efforts to remake the environment in different parts of the world and their consequences offers crucial object lessons in how humans have responded to nature's own creativity. Both approaches to historical materialism highlight the virtues of a more interdisciplinary approach to historical scholarship, in the museum or in the field, but most important, in our own sensibilities about what it means to think historically with artifacts and to treat them as compelling evidence of a shared history of humanity and nature.     

The use and abuse of paradigms in the history of political thought

A paradigm is a methodological device which historians of political thought borrow from the history of science. The initial part of this article examines the views of three distinguished historians of political thought—Sheldon Wolin, Alan Ryan and John Pocock—who have borrowed paradigms. Wolin and Ryan are shown to have confused paradigms with weltanschauungen in such a way as to make the former less useful as methodological devices. Pocock, on the other hand, has been successful in his use of paradigms, though he does not sufficiently recognise their methodological limits. He also raises a conceptual problem. The latter part of this article examines the recent history of science in an attempt to clarify the use of paradigms and their limits.     

Wissenschaftsgeschichte und Wissenschaftsphilosophie – Einführende Bemerkungen

History of Science and Philosophy of Science. Introductory Remarks. This article introduces two special issues of the journal History of Science Reports (Berichte zur Wissenschaftsgeschichte) with contributions on the relationships of history and philosophy of science since the seventeenth century. The introduction begins with a brief reminder of Thomas Kuhn's provocative discussion of the relationship in the 1970s, placing it in the context of the debate of the period over whether the foundation of university departments for History and Philosophy of Science in the United States had led to a mere “marriage of convenience” or something more. Following this the paper briefly outlines the transformative impact of the “practical turn” in both philosophy and history of science since the 1990s, and contends that the relationship of history and philosophy of science has nonetheless become increasingly distant over time. This is due in large part to the professionalisation of history of science and to the recent turn to cultural approaches in that field; both trends have led to the adoption of strictly historicist rather than analytical perspectives on knowledge. General historians, too, are paying more attention to the increasing impact of science and technology, but have at most instrumental use for philosophical perspectives. Thus, the distinct possibility arises that the debate between historical and analytical approaches in philosophy of science is becoming a conversation within one discipline rather than a dialogue between two disciplines: what was once a ?marriage of convenience”? could end in respectful separation or amicable divorce. The article concludes with brief summaries of the articles published in the two special issues, indicating their relations to specific aspects of the broader topic at hand.     

Public technology: nuclear energy in Europe

ABSTRACT

The concept of ‘public science’ has been fruitfully used to indicate the intricate interrelatedness of science and society. In studies of knowledge and its publics, however, technology has been routinely subsumed under science and the distinctive nature of technical knowledge neglected. We are aiming in this article at conceptualizing the public nature of technologies. First, we start with surveying the literature on public science. Second, we scrutinize various conceptual approaches to better understand the social and cultural factors embedded in technologies. In so doing, we reflect upon the twentieth-century history of technologies as public things. Third, we focus on nuclear energy in Europe as an exemplary case of a large-scale technology which has been shaped as part of public culture. We suggest that the specificities of the nuclear as a publicly shaped societal entity can be understood as an example of the wider category we propose to call ‘public technologies’.     

Von Vielschichtigkeiten und Verschränkungen “Kulturen der Wissenschaft – Wissenschaften in der Kultur”

On Multiple Levels and Linkages: Introduction to the Symposium ‘Cultures of Sciences – the Sciences in Culture’. – The article presents briefly approaches to cultural history and cultural studies that seem potentially useful to or have recntly been applied in historical studies of the sciences. The first section discusses three such approaches: discourse analysis, symbolic artefacts (images and text), and cultures of scientific practice. Each of the three approaches raises issues of its own, and all of them share a common problem characteristic of cultural and social history in general: linking micro and macro levels of analysis. The second section presents three approaches to resolving this dilemma by focusing on specific linkages between cultures of science (or culture in the sciences) and general history: scientific thought and practice as norms for professional behavior, for example in fields of knowledge dominated by women; spaces of knowledge, for example the city; and linkages of cultural, media and economic history in fields such as radio and television.     

The Bourbon monarchy and prison legislation in Sicily: two competing plans for reform (1826–1830)

The nineteenth century was a critical phase in the construction of European penitentiary systems. The eighteenth century had seen the evolution of the concept of punishment and the corresponding development of the practice of imprisonment as central to new ideas about penal sanctions. As a result, between 1830 and 1848 grand plans to reform prison systems were put forward in almost all the larger European countries. The Kingdom of the Two Sicilies played its part in this process: an innovative reform plan was developed here, ahead of the rest of the Italian peninsula, which was fully implemented between 1832 and 1845 but had its origins in an earlier period, being given its initial impetus by modernisation on the legislative front. Sicily was particularly rich in terms of legal experimentation in this area. Here, informed by the most recent developments in contemporary science, plans to reform prison legislation were produced as early as the 1820s; these attest to the interest with which lawyers, philanthropists and government officials approached the issue. The analysis of two plans discovered in the Archivio di Stato in Palermo is especially helpful in demonstrating the existence of a ‘workshop for prison legislation’ that addressed concrete problems while also being the manifestation of a sophisticated legal culture.     

Models of war 1770–1830: the birth of wargames and the trade-off between realism and simplicity

The first sophisticated wargames (military board games) were developed between 1770 and 1830 and are models of military conflict. Designers of these early games experimented fruitfully with different concepts that were formulated in interaction with the external dynamics of the military systems that they tried to represent and the internal dynamics of the design process itself. The designers of early wargames were confronted with a problem that affects all models: the trade-off between realism and simplicity, which in the case of wargames amounts to the trade-off between realism and playability. I try to show how different game concepts were developed as an answer to this problem, and how these seemingly arcane concepts form a relevant topic of investigation in the history of ideas. Moreover, a direct offshoot of this conceptual experimentation between 1770 and 1830 was the ‘free’ German wargame (Kriegsspiel), which became an integral part of German operational planning in the nineteenth and twentieth centuries, thus adding another chapter to the story of the influence of ideas on human history.