Neurognostics Question

Abstract

Dopamine is among the most well‐researched neurotransmitters at the present time. For the first half‐century of neurotransmitter research, however, interest in dopamine was minimal, and only a few scattered groups of researchers studied it. It was their research that stimulated current interest, and provided the background for our present understanding of this important substance. By the late 1950s, it was clear to these individuals that dopamine served an important physiological role in mammalian brains, and that its role was most likely that of a central nervous system agonist. Soon after this, dopamine, or more specifically the depletion of dopamine, was clearly implicated in Parkinson's disease. This paper looks at the early history of the physiological roles of this intriguing compound.     

Question 16: Answer

Sir William Osler (1849–1919) is associated with a long list of contributions and eponymous entities including filaria, maneuvers, nodules, syndromes, and triads. Among the less known ones is the Oslerian pulling of the tongue for termination of obstinate hiccup (singultus). Janet Travell (1901–1977) Travell, JG. 1977. A trigger point for hiccup. Journal of the American Osteopathic Association, 77: 308–312. [PubMed] , [Google Scholar], physician to two United States presidents, attributed the tongue-pulling maneuver to Osler. Dr. Travell cites Osler's Principles and Practice of Medicine from 1912, where mention of the remedy can be found. The therapy, however, is much older and (perhaps not surprisingly) of French origin. It can be viewed as a spin-off of attempts by Jean Laborde (1830–1903) to resuscitate the “presque morts” (almost dead) via rhythmic traction of the tongue. Lesser known physicians involved in the treatment of singultus by traction of the tongue are Jean Viaud (1862–1946) and Raphaël Lépine (1840–1919).