Five scientists at Johns Hopkins in the modern evolution of neuroscience

Neuroscience's evolution at Johns Hopkins, from neurophysiology to the new field of neurobiology, though unplanned, was rapid and important. Beginning in 1933 when Philip Bard became professor of physiology at Johns Hopkins, members of his department concentrated initially on neuroanatomical control of placing reactions and sexual activity. Vernon Mountcastle, extending available techniques, discovered vertical somato-sensory columns in the 1950's. Stephen Kuffler, who arrived at Hopkins in 1947, was a pioneer in single unit microelectrode recording techniques. He soon attracted scientists from all over the world to his laboratory. Among them, Torsten Wiesel and David Hubel discovered vertical neuronal columns in the visual cortex. During several decades at Johns Hopkins, these five scientists set extremely high scientific standards and established a climate of inquiry in which ideas were shared and young scientists encouraged. They contributed significantly to the emerging discipline of neuroscience.     

Neurognostics Answer

William S. Halsted was the founding chief of surgery at the Johns Hopkins Hospital. Among his basic principles were (1) the use of the experimental laboratory to solve intraoperative surgical problems, (2) gentle handling of all tissues, and (3) full-time surgical subspecialization. Halsted trained Harvey Cushing, who used Halsted's principles to reinvent neurosurgery to make it successful by lowering mortality and morbidity rates.     

Henry Herbert Donaldson’s (1857–1938) contribution to an organized approach to the experimental study of the mammalian central nervous system

ABSTRACT

This article shows that the academic and research careers of Henry Herbert Donaldson (1857–1938) were directed to provide basic information about the growth of the vertebrate nervous system and to provide standards and the means to make such research efficient. He earned the reputation of making the albino rat a standard laboratory animal. His academic career began when he was an undergraduate at Yale University in 1875 and concluded with his death as Professor and Head of the Department of Neurology at the Wistar Institute of Anatomy and Biology of the University of Pennsylvania in 1938. During that period, pivotal experiences occurred, including research in physiological chemistry with Chittenden at the Sheffield School at Yale, graduate study at Johns Hopkins University, postgraduate study in Europe, and professorial positions at Clark University and the University of Chicago. It was at Johns Hopkins University that Donaldson learned about the need for physiological, anatomical, and psychophysical research and about the techniques to allow such research. It was at Clark University that he had first-hand and detailed experience with the anatomy of the brain of a deaf-blind-mute woman, as he attempted to correlate her sensory deficits with her brain development. It was at Clark University that he clearly recognized the need for standardization in neurological research. At the University of Chicago, he developed administrative skills and began a coordinated research effort to delimit the growth of the nervous system. It was at Chicago that he learned that the albino rat could be a reasonable subject for such research. It was also at Chicago that he was able to formulate ideas about the future organizational needs of human neuroanatomy. It was at the Wistar Institute that his research program and his professional career matured. He organized a research effort to elucidate the growth of the nervous system. He contributed to the coordination of neurological research in the United States and Europe. It was while at the Wistar Institute that he became well-known for making the albino rat a standard laboratory mammal—a convenient living material for research.     

Balance of Power and Political Equilibrium: A Response

This article analyses the international thought of the US sinologist and political advisor Owen Lattimore (1900–89). A well-known expert on China and the Far East, Lattimore was a ‘public intellectual’ and advisor to Chiang Kai-shek and Franklin D. Roosevelt. In 1950, after Senator Joseph McCarthy accused him of Soviet espionage, Lattimore's reputation was irrevocably damaged and his political thought forgotten. By assessing his visions of global democracy and geopolitics, this article claims Lattimore made insightful contributions to international thought. On the eve of the cold war, Lattimore's ideas of pluralistic democracy and tripolar world order offered an alternative vision of the post-war era, focusing on political participation and diversity. This article focuses on Lattimore's published writings in the 1940s, when, as political advisor and director of the Johns Hopkins’ Page School of International Relations, he sought to shift international attention from Europe to the Far East as the potential birthplace of a new version of post-colonial democracy. A fervent anti-imperialist, Lattimore crafted new political space for global democracy in a post-imperial age. His thoughtful discussion of participation, co-operation, democracy, knowledge, and pluralism make his vision of world order an interesting contribution to international thought in the twentieth century.     

The Volatility of Sex: Intersexuality,Gender and Clinical Practice in the 1950s

The term ‘gender role’ was coined at Johns Hopkins's paediatric endocrinology clinic in the 1950s, where Dr Lawson Wilkins and psychologist John Money diagnosed, treated and evaluated intersexual children, most of them suffering from a condition called congenital adrenal hyperplasia (CAH). Going beyond existing discourses on the medicalisation of intersexuality, I reframe the emergence of gender as an element in the development of a specific medical treatment for an endocrinological condition and excavate the complex and contingent historical factors that led to the formulation of gender role in the Hopkins context. Using previously unavailable patient records from the clinic, this article follows the patients through their medical encounters and describes the process of normalisation around the diagnosis, treatment and management of CAH. By paying specific attention to the practices at the clinic, I show that diagnosing a child's sex often depended on the physicians’ skill, experience and techniques. Correct gender role was folded into the management of CAH as one aspect of successful treatment. Normalisation was a process, in which treating somatic effects and assuring psychological healthiness were deeply enmeshed in the conviction that a normal life would only be possible as a clearly gendered and sexed person.     

REPORT The British Contribution to the Neurosciences

The evolution of techniques to manage patients with head injuries has served as the basis for the treatment of other neurosurgical disorders, including brain tumors, intracranial infections, and cerebrovascular disease. In the nineteenth century, advances in anesthesia, asepsis, and cerebral localization slowly took hold and created the groundwork for modern neurosurgery. To better understand the advances in the treatment of brain injuries in the late 1800s and early 1900s, we examine relevant historical literature and, through the courtesy of the Alan Mason Chesney Medical Archives, we review Dr. Harvey Cushing's patient records (1898–1909) in the Johns Hopkins Hospital surgical archives. The original case histories of 10 patients (6 in detail) who suffered head injuries and underwent treatment by Cushing illustrate some of Cushing's early attempts at intracranial surgery. We also examine the influences on Cushing as he developed into a leader in the new era of modern neurosurgery.     

‘Seeing in the Dark’: Franz Joseph Thun and his Encyclopedia

Abstract

In the late 1790s the extravagant Bohemian aristocrat Franz Joseph Thun (1734–1801) composed a massive encyclopedia containing his wide-ranging and esoteric knowledge, which was not discovered until 2009. In this article I discuss the contents of his encyclopedia and investigate Thun’s place within the broader intellectual climate in Central Europe. I argue that Thun was an exceptional case in the Habsburg context, where scientists generally rejected outright the sort of excesses his encyclopedia contains. None the less, he became famous for his experiments with a spirit named ‘Gablidon’ and for his sessions in Mesmerism. His encyclopedia focuses on three topics: human ethics, man’s place in nature, and the sins of the French Revolution. He saw man as the middle link in the ‘great chain of being’, whose morality must be based on submission to God. Although he distanced himself from the Catholic Church, he rejected the French Revolution as an attempt to establish a state without religious basis.     

An ‘all-seeing flying eye’: V-2 rockets and the promises of Earth photography

In 1950 National Geographic published one of the first large-scale images of the curvature of the Earth. Clyde T. Holliday of the Applied Physics Laboratory at Johns Hopkins University constructed the mosaic, which was taken from a camera affixed to a V-2 rocket launched from White Sands Proving Ground, New Mexico. Holliday crafted the image as a bellwether for two contradictory yet inextricable ideas: the promise of Earth photography in making life easier for everyday peoples and the militarization of space. Examining one pre-1960 rocket-based Earth image this essay offers a reassessment of Earth photographs as only environmentalist texts.     

The intercalatus nucleus of Staderini

Rutilio Staderini was one of the leading Italian anatomists of the twentieth century, together with some scientists, such as Giulio Chiarugi, Giovanni Vitali, and others. He was also a member of a new generation of anatomists. They had continued the tradition of the most famous Italian scientists, which started from the Renaissance up until the nineteenth century. Although he carried out important studies of neuroanatomy and comparative anatomy, as well as embryology, his name is rarely remembered by most medical historians. His name is linked to the nucleus he discovered: the Staderini nucleus or intercalated nucleus, a collection of nerve cells in the medulla oblongata located lateral to the hypoglossal nucleus. This article focuses on the biography of the neuroanatomist as well as the nucleus that carries his name and his other research, especially on comparative anatomy and embryology.     

Direct Acceleration Feedback Control of Shake Tables with Force Stabilization

This study presents a new strategy for shake table control that uses direct acceleration feedback without need for displacement feedback. To ensure stability against table drift, force feedback is incorporated. The proposed control strategy was experimentally validated using the shake table at the Johns Hopkins University. Experimental results showed that the proposed control strategy produced more accurate acceleration tracking than conventional displacement-controlled strategies. This article provides the control architecture, details of the controller design, and experimental results. Furthermore, the impact of input errors in shake table testing on the structural response is also discussed.     

Transatlantic Correspondence and ‘Mobile Knowledge’ in Alexander von Humboldt's Exploratory Travels to Hispanic America

Summary

This article focuses on the relevance of Alexander von Humboldt's correspondence in the formation of transatlantic scientific networks at the beginning of the nineteenth century. Apart from connecting Humboldt with scientists and scholars worldwide, his correspondence turned out to be a fundamental tool for assuring the material conditions and the social and scientific connections he needed to carry out his research on the Spanish colonies and to simultaneously diffuse his achievements on the European side of the Atlantic. His contact with Hispanic American scientists and with the local elites enabled him to build a broad social network, gaining access to key material, human and intellectual resources. The letters sent to scientists, scientific institutions and noblemen in Europe, for their part, kept Humboldt's European correspondents informed about his activities in Hispanic America, contributing to the validation of his work before the scientific community and the fulfilment of the duties resulting from the political and institutional support he received both before and during his travels. This stresses the importance of strategic social groups and their cooperation in the framework of exploratory travels as a means to gaining access to resources in the peripheries. It also reveals the scientist's dependence on all those who supported his research: kings, barons, botanical gardens, universities, and academies.     

Oppression or liberality

Jerome S. Handler. The Unappropriated People: Freedmen in the Slave Society of Barbados. Baltimore: The Johns Hopkins University Press, 1974. xii + 225 pp. Maps, tables, illustrations, and index. $10.00 (cloth).     

IIR Compensation in Real-Time Hybrid Simulation using Shake Tables with Complex Control-Structure-Interaction

This article considers the use of actuator compensation in real-time hybrid simulation (RTHS) containing experimental substructures with complex control-structure-interaction (CSI). The existence of CSI in shake table testing is derived using theoretical relations. An infinite-impulse-response (IIR) compensator is developed to compensate for the shake table time delay as well as the effects of CSI. The efficacy of the IIR compensator is verified through numerical and experimental investigations of substructure shake table testing completed at Johns Hopkins University. IIR compensation is not limited to substructure shake table testing, and the concept is applicable to any RTHS that suffers from complex CSI.     

Review Article: Nations and Empires in Colonial North America

GREGORY EVANS DOWD. War under Heaven: Pontiac, the Indian Nations, and the British Empire. Baltimore and London: Johns Hopkins University Press, 2002. Pp. xvi, 360. $32.00 (US); ERIC HINDERAKER and PETER C. MANCALL. At the Edge of Empire: The Backcountry in British North America. Baltimore: Johns Hopkins University Press, 2003. Pp. ix, 210. $17.95 (US), paper; JANE T. MERRITT. At the Crossroads: Indians and Empires on a Mid-Atlantic Frontier, 1700–1763. Chapel Hill and London: University of North Carolina Press, 2003; dist. Toronto: SBS. Pp. vi, 338. $32.95 (CDN), paper; MICHAEL LEROY OBERG. Uncas: First of the Mohegans. Ithaca and London: Cornell University Press, 2003. Pp. ix, 268. $27.50 (US). Reviewed by Gary Clayton Anderson     

Auroral Research and the Character of Astronomy in Enlightenment Sweden

Abstract

The observation of the magnetic effects of the aurora borealis by Olof Hiorter in the 1740s was hailed by Swedish scientists as one of the major discoveries in contemporary research. This article investigates the political and academic context of the discovery, focusing on the astronomical ideals promoted by Hiorter. He used the discovery in order to buttress the importance of his own scientific character – technically competent, hard-working and research-oriented. He contrasted this ideal with the character of an ordinary university professor who was described as more of a bureaucrat, interested in science only as long as it could boost his reputation, and not averse from stealing results of technically more competent underlings. Hiorter's opponents at the university decried his lack of theory and devalued the importance of technical skill. This conflict is discussed in the context of ideals concerning cultural, political and economic values of science and scientists.     

High-Modernist Dreams and Nightmares

Book reviewed:
David C. Engerman. Modernization from the Other Shore: American Intellectuals and the Romance of Russian Development . Cambridge, MA: Harvard University Press, 2003. vi + 399 pp. Essay on sources, notes, index. $49.95 (cloth).
Nils Gilman. Mandarins of the Future: Modernization Theory in Cold War America . Baltimore: Johns Hopkins University Press, 2003. xi + 329 pp. Essay on sources, notes, index. $48.00 (cloth).     

Arctic Explorer Robert E. Peary’s Other Quest: Money,Science, and the Year 1897

American Robert E. Peary is famous for his claim of being the first person to reach the North Pole. However, too little historical attention has been paid to independent parts of his long exploratory career. A closer examination of one year, 1897, in his two‐decade quest, reveals the substantial difficulties of being an explorer at the turn of the twentieth century. Peary used specially crafted arguments to endear himself to the recently organized but poorly connected professional scientists who proved to be his most earnest, if inconsistent, backers before 1898. Peary worked on the scientists’ behalf to locate, and sometimes create, publishing venues and stateside audiences for them, in exchange for their patronage. The money chase was difficult and time‐consuming, but did more than help the scientists and ensure Peary’s future backing. It introduced him to the young American scientific community, with whom he learned to “sell” the Arctic. Peary also used his scientific credentials to maintain a public image of the Arctic that allowed Americans to celebrate both the rugged hero and cultural superiority in this remote region.     

The Reagan Presidency and the Reagan Experiment

Fred I. Greenstein, ed., The Reagan Presidency: An Early Assessment. Baltimore and London: Johns Hopkins University Press, 1983. Pp. 196. $7.95 softbound. John L. Palmer and Isabel V. Sawhill, eds., The Reagan Experiment: An Examination of Economic and Social Policies under the Reagan Administration. Washington, D.C.: The Urban Institute Press, 1982. Pp. xvii, 523. $29.95 hardbound; $12.95 softbound.     

William speirs bruce,the ben nevis observatory,and antarctic meteorology

Following his participation in an expedition to the Weddell Sea (1892–1893), William Speirs Bruce determined to undertake further polar research and sought training and experience in such techniques and methodologies as might prove useful to him in securing opportunities to participate in future expeditions. During 1895–1896 he worked at the Ben Nevis Observatory gaining experience of meteorological research. The experience he gained in the design and operation of an observatory in a harsh environment he was later to apply when he established an observatory on Laurie Island, South Orkneys. This paper draws on a recently discovered archival source (Swinney (2001) to re‐examine Brace's involvement with the Ben Nevis Observatory.     

Émile Meyerson,d'après sa correspondance

Building upon Emile Meyerson's correspondence and other personal papers, all of them hosted by the Central Zionist Archives in Jerusalem, this article presents a mainly personal portrait of the philosopher (1859–1933). Thus this article describes his family circle in Lublin (Poland), his higher education (in Germany) and his professional course: settled in France, he worked first in chemistry, then get a job as foreign news editor and later took an important position at the Jewish Colonization Association. This article deals also with Meyerson's contacts with the French and international intellectuel milieu (scientists as well as writers).