Historical aspects of cerebrotendinous xanthomatosis (CTX)

Thomas Willis made numerous contributions to the neurosciences that were broad in scope. In an age of scientific breakthroughs and intellectual revolutions, Willis bestowed upon medical research the clinical rigor that set the stage for subsequent medical breakthroughs. In Cerebri Anatome, Willis introduced a measure of empiricism hitherto unknown in medieval times. By coupling the delineation of brain and neural anatomy with functional studies, Willis brought the science of clinical neurology into fruition. Psychiatry, too, benefited from Willis' elucidation of mental illness and intellectual disability, and modern behavioral psychologists claim Willis as one their early, most ardent champions.     

The life and times of Thomas Willis and his impact on contemporary medicine

Thomas Willis made numerous contributions to the neurosciences that were broad in scope. In an age of scientific breakthroughs and intellectual revolutions, Willis bestowed upon medical research the clinical rigor that set the stage for subsequent medical breakthroughs. In Cerebri Anatome, Willis introduced a measure of empiricism hitherto unknown in medieval times. By coupling the delineation of brain and neural anatomy with functional studies, Willis brought the science of clinical neurology into fruition. Psychiatry, too, benefited from Willis' elucidation of mental illness and intellectual disability, and modern behavioral psychologists claim Willis as one their early, most ardent champions.     

Charcot in contemporary literature

Charcot and his medical observations remain an enduring topic of scientific study in neurology, but he is also the topic of modern literary works. This essay examines the depiction of Jean-Martin Charcot (1825-1893) as a character in late-twentieth-century literature as an index of the contemporary nonmedical literary public's interest in neurology and Charcot. It focuses on three contemporary works that involve Charcot as a central figure with comparison between primary source documents and the rendered context, character development, and plot lines of these literary works. The two French novels [Slumbers of Indiscretion and Dr. Charcot of the Salpêtrière] and one American play [Augustine (Big Hysteria)] approach Charcot and neurology with differing levels of historical accuracy. All create a figure of authority, each with a different coloration of the balance between power and its abuse. Two focus almost exclusively on his work with hysteria and inaccurately amplify Charcot's concern with symbolic sexual conflict as the origin of hysteria and fictionalize more extensive interactions with Freud than historical documents support. The three works demonstrate that Charcot retains an enduring fascination with an enigmatic personality, a controversial career, and a pivotal role in the development of studies involving the brain and behavior. Neurologists should not look to these works as replacements for more seriously composed historical studies, but as enrichments anchored in the imaginative possibilities of Charcot and his fin de siècle era.     

William Alexander Hammond: The Centenary of His Death

In the United States, the field of clinical neurology began within the medical practice of a single physician, William Alexander Hammond. In the 1870s, this New York medical practitioner became the first American physician who limited his practice to patients who suffered from symptoms potentially due to dysfunction of the nervous system. From the experience of his huge practice, Hammond wrote the first American textbook of neurology. With Silas Weir Mitchell, he founded the American Neurological Association. The year 2000 marked the 100th anniversary of Hammond's death and stimulates this brief survey of his life.     

Anthropological neurology: symptoms and their meanings according to Joseph Prick (1909-1978)

This article describes the life and work of the Dutch neurologist Joseph Prick (1909-1978) and his idea of an anthropological neurology. According to Prick, neurological symptoms should not only be explained from an underlying physico-chemical substrate but also be regarded as meaningful. We present an outline of the historical and philosophical context of his ideas with a focus on the theory of the human body by the French philosopher Maurice Merleau-Ponty (1908-1961) and the concept of anthropology-based medicine developed by Frederik Buytendijk (1887-1974). We give an overview of anthropological neurology as a clinical practice and finally we discuss the value of Prick's approach for clinical neurology today.     

G.I. Rossolimo (1860-1928) neurologist and public benefactor

G.I. Rossolimo was attracted to neurology as a medical student in the late nineteenth century and remained affiliated with Moscow University most of his life. His training included psychiatry, neuropathology, and laboratory research in his postgraduate years. The domain of his neurological clinical interests was vast. His most enduring efforts were directed toward neurological illnesses and developmental delay. He established a children's institute for neurology and psychology that was the first of its kind in Russia. In addition he developed a neuropsychologic examination for assessing cognitive function. His sustained interests were pursued during and after revolutionary changes in his government.     

The first career of William Alexander Hammond

Neurology in its modern sense was first studied in the well-known neurological institutions of France and England. In America, however, this new field of medicine was developed by a physician in a private practice, Dr. William Alexander Hammond. This article addresses the question how Hammond was able to limit his practice to neurology. It is argued that Hammond was a famous military physician before becoming the first practitioner of clinical neurology in America. This fame translated into a large referral base.     

Domus Willisi: a neuro-architectural tour

Fifteen sites in England today can be identified with Dr. Thomas Willis, the Oxford physician and anatomist, who was the founder of neurology. Four of these were domiciles; Beam Hall, where Willis and his colleagues met to study the brain and nerves, can be claimed as the first Neurological Institute. The last dwelling place of Willis is Westminster Abbey, where in 1961 his memorial stone was renewed by neurologists and neurosurgeons. Part of this original stone marks the new Brain Imaging Centre at the Montreal Neurological Institute, where the name of Thomas Willis shares a place in the Hall of Neurological Fame.     

A Note on Marinus of Alexandria

Abstract

Neurology in its modern sense was first studied in the well‐known neurological institutions of France and England. In America, however, this new field of medicine was developed by a physician in a private practice, Dr. William Alexander Hammond. This article addresses the question how Hammond was able to limit his practice to neurology. It is argued that Hammond was a famous military physician before becoming the first practitioner of clinical neurology in America. This fame translated into a large referral base.     

Domus Willisi: A Neuro‐Architectural Tour*

Abstract

Fifteen sites in England today can be identified with Dr. Thomas Willis, the Oxford physician and anatomist, who was the founder of neurology. Four of these were domiciles; Beam Hall, where Willis and his colleagues met to study the brain and nerves, can be claimed as the first Neurological Institute. The last dwelling place of Willis is Westminster Abbey, where in 1961 his memorial stone was renewed by neurologists and neurosurgeons. Part of this original stone marks the new Brain Imaging Centre at the Montreal Neurological Institute, where the name of Thomas Willis shares a place in the Hall of Neurological Fame.     

Anthropological Neurology: Symptoms and Their Meanings According to Joseph Prick (1909–1978)

This article describes the life and work of the Dutch neurologist Joseph Prick (1909–1978) and his idea of an anthropological neurology. According to Prick, neurological symptoms should not only be explained from an underlying physico-chemical substrate but also be regarded as meaningful. We present an outline of the historical and philosophical context of his ideas with a focus on the theory of the human body by the French philosopher Maurice Merleau-Ponty (1908–1961) and the concept of anthropology-based medicine developed by Frederik Buytendijk (1887–1974). We give an overview of anthropological neurology as a clinical practice and finally we discuss the value of Prick's approach for clinical neurology today.     

S. Weir Mitchell's prose and poetry on the American Civil War

The prose and poetry of S. Weir Mitchell (1829-1914)--related to the American Civil War--encompass a very significant portion of his non-medical writings. The Civil War, more than any other single event, shaped his future career as one of the founders of American neurology. Indeed, it should not be surprising how the war was also such a driving force in his non-medical writings. His novels, once widely read, now are scarcely noted. His accounts of the social, political and economic events of the Civil War are of historical interest to students of the period. Neuroscientists as a group, like others, are apt to be unfamiliar with these writings, with the possible exception of "The Case of George Dedlow." A major purpose of this essay is to introduce readers, especially neuroscientists, to Weir Mitchell's fictional works in which neurological cases so often appear. One appreciates more the medical aspects of his novels, written as they were by a first-hand observer. His non-medical writings, poetry and prose, are to a large extent timeless and can be appreciated by today's readers.     

Neurological caricatures since the 15th century

During the Renaissance, different artists began to draw medical illustrations from various viewpoints. Leonardo da Vinci was among those who sought to portray the emotional as well as the physical qualities of man. Other European artists described caricatural aspects of medical activities. In Northern Europe, Albrecht Durer, Hieronymus Bosch, and Pieter Brueghel were also famous for drawing caricatures. Later English artists, notably William Hogarth, Thomas Rowlandson, James Gillray, and the Cruikshanks, satirized life in general and the medical profession in particular. In Spain, Francisco Goya's works became increasingly macabre and satirical following his own mysterious illness and, in France, Honore Daumier used satire and humor to expose medical quackery. Also physicians such as Charles Bell and Jean-Martin Charcot were talented caricaturists. Their own personal artistic styles reflected their approach and gave a different "image" of neurology. Caricatures were popular portraits of developments in science and medicine and were frequently used whenever scientific language was too difficult to disseminate, in particular in the field of neurology.     

Herophilus of Chalcedon and the Hippocratic tradition in early Alexandrian medicine

Herophilus of Chalcedon (c. 330-250 BC) is famous as one of the leading figures in the development of medicine in Ptolemaic Alexandria around the first half of the third century BC. However, his medical science seems to have intrinsic continuity of thought with Hippocratic medicine. Herophilus followed the medical principle formulated in the Hippocratic treatise "On the Nature of Man," when he made his methodological pronouncement to the effect that primary parts of the human body should be perceptible by the senses. Herophilus rejected cardiocentrism, introduced by his teacher Praxagoras into the medical school of Cos, and returned to Hippocratic encephalocentrism, as represented by the author of the Hippocratic treatise "On the Sacred Disease." Herophilus differentiated between the faculties of the soul and the ones attributed to the nature. In his differentiation between these two faculties, Herophilus probably had in mind the Hippocratic conception of nature as specifically applied to the domain of the human body, as distinct from the soul. Herophilus' commitment to Hippocratic medicine is confirmed by his literary works on some of the Hippocratic texts. It is probable that Herophilus regarded himself as a more faithful successor than his teacher to the tradition of Hippocratic medicine. His anatomical research on the structure and function of the brain, motivated by his loyalty to the Hippocratic tradition, led him to innovative contributions to the development of medicine.