MESOGLIA & MICROGLIA – A Historical Review of the Concept of Mononuclear Phagocytes Within the Central Nervous System

More than a century and a half has elapsed since the first accounts of mesodermal phagocytic elements were proposed within the central nervous system. Over the intervening decades, body and substance were added to this concept through the advancement of histological techniques at the disposal of the researcher and the acute and keen-minded skills of the pathologist. Notable among these pioneering efforts were the contributions of W. Ford Robertson, Santiago Ramon y Cajal, Pio del Rio-Hortega and Wilder Penfield amongst an entire cavalcade of other noteworthy figures. The term ‘mesoglia’ and ‘third element of the nervous system’ was bestowed upon these cells towards the beginning of the twentieth century to account for their separate origins from neurons and macroglia. It was later amended by del Rio-Hortega in 1919, to ‘microglia’ in order to further discriminate between true mesodermal elements and oligodendrocytes, previously regarded as a component of ‘mesoglia’. This particular contention sparked much controversy among del Rio-Hortega’s peers and resulted in an escalation of fruitful research throughout Europe that eventually declined up to the outbreak of the Second World War. The post-war years were a period of the ‘dark ages’ that cast doubt on the very existence and nature of microglia, until the ‘renaissance’ of research was once again rejuvenated in the 1960s, by a new cohort of intrigued minds: Cammermeyer, Blinzinger, Kreutzberg and others who saw in the ‘third element’ the potential that is now commonly ascribed to microglia: the intrinsic immune effector cells of the CNS. It is now universally accepted that microglia are involved as the first line of rapid defence in any pathology of the nervous system, and as such, present a diagnostic tool for the neuropathologist. Although our knowledge of microglia stems from an extensive body of work conducted over the last two decades, much of the earlier work (pre-1960s) has remained somewhat obscure. This is partly accountable due to the limited availability of translated works, and additionally to the lack of a compendium of these articles. This paper will present a comprehensive overview of the pioneering research on mononuclear phagocytes within the central nervous system, which has direct bearing on our present-day understanding of the concept of microglia.     

Evolution of the concept of "extracellular matrix' in the brain

The question as to whether an extracellular matrix exists between cells in the adult brain has been debated since the end of the last century. In the early years, zones containing neuropil and glial processes were mistakenly believed to represent this substance. But Golgi's discovery of the "perineuronal net" paved the way for future study of the true extracellular matrix. In the 1950s, application of histochemical techniques established the existence of interstitial material between nerve cells. Unfortunately the similarity between the pericellular distribution of this material and Golgi's "pericellular nets" was overlooked. The detection of an extracellular volume fraction in the central nervous system furnished further indirect proof for the existence of an extracellular matrix in the brain. However, the repeated failure of electron microscopy to reveal a substantial space between cell processes undermined the acceptance of the concept of "extracellular matrix" in the central nervous system. Nowadays this concept has, however, been firmly established.     

Making the brain plastic: early neuroanatomical staining techniques and the pursuit of structural plasticity, 1910-1970

The concept of neuronal plasticity is widely used, but seldom defined in the neurosciences. It can signify many different occurrences, such as structural alterations of axons and dendrites (Cotman & Nadler, 1978), behavioural adaptations (Rosenzweig & Bennett, 1996), or physiological changes in synapse formation (Martin et al., 2000) at different stages of health and disease. Although there is such a wealth of research from many disciplines, the neuroanatomical aspects of plasticity are the focus of this paper. It seeks to illuminate the evolution of different concepts of plasticity concerning the structure and circuitry of the central nervous system (CNS). Early modern morphological research on de- and regeneration phenomena in the 19th- and early 20th-century is well documented. These studies, however, almost exclusively concentrated on the peripheral nervous system (PNS). It was one of the major contributions of Santiago Ramón y Cajal (1852-1934), that he applied the concept of regenerative capacities to the CNS. But the term plasticity seemed to have disappeared for about two decades after his death. The ensuing comeback of the expression may be attributed, at least in part, to new neuroanatomical staining and tracing methods. The pursuit of these techniques will serve as a guidepost through varying approaches in different times: It was the 1950s which seemed to spawn the time for new departures in structural investigations of neuronal plasticity.     

What was the Religious Crisis of the 1960s?

The crisis of the 1960s is now central to debates about religious change and secularisation in the twentieth century. However, the nature of the crisis is contested. Using Hugh McLeod's The Religious Crisis of the 1960s (2007) as a starting point, this article explores the issues that divide scholars — the origin and length of the crisis (was it revolution or evolution?); was it generated more by developments within the Christian churches or by developments without them; and what was the relative importance of liberal Christianity versus conservative Christianity in the development and legacy of the crisis? It argues that secularisation of the period should be regarded as mostly a sudden and shocking event, based on external threats, and reflected in the churches dividing between liberals and conservatives in ways that were to become ever more militant as the century wore on.     

Acceptance of the Neuron Theory by Clinical Neurologists of the Late-Nineteenth Century

This article explores reactions of clinical neurologists of the late-nineteenth century to the concept of a unified nerve cell, the “neuron,” which developed from the research on fine anatomy of the nervous system and from conclusions of Waldeyer based on that research. Assessment shows that Waldeyer's role in the acceptance of the neuron theory was not straightforward. A study of primarily American medical literature shows rapid acceptance, eager applications, and high expectations. Nonetheless, some clinicians were disappointed in its immediate relevance. An explanation for this disappointment is offered.     

Acceptance of the neuron theory by clinical neurologists of the late-nineteenth century

This article explores reactions of clinical neurologists of the late-nineteenth century to the concept of a unified nerve cell, the "neuron," which developed from the research on fine anatomy of the nervous system and from conclusions of Waldeyer based on that research. Assessment shows that Waldeyer's role in the acceptance of the neuron theory was not straightforward. A study of primarily American medical literature shows rapid acceptance, eager applications, and high expectations. Nonetheless, some clinicians were disappointed in its immediate relevance. An explanation for this disappointment is offered.     

The development of the flour-milling industry in Spain: analysis of its historical evolution and architectural legacy

The second half of the 19th century, along with the first three decades of the 20th, saw the building of hundreds of flour mills in Spain, all based on new milling and sieving machinery developed after the industrial revolution. Unfortunately, very few of these early mills are now in use: most have disappeared, and many of those that are left have been abandoned. The present work examines the growth of the flour-milling industry in Spain from the mid-19th century, and discusses the typology, design and constructional features of its associated buildings. The information presented is the result of the study of a representative sample of these mills in central Spain, and could serve as a basis for the conservation, rehabilitation and reuse of this important agroindustrial heritage.     

Making the Brain Plastic: Early Neuroanatomical Staining Techniques and the Pursuit of Structural Plasticity, 1910–1970

The concept of neuronal plasticity is widely used, but seldom defined in the neurosciences. It can signify many different occurrences, such as structural alterations of axons and dendrites (Cotman & Nadler, 1978), behavioural adaptations (Rosenzweig & Bennett, 1996), or physiological changes in synapse formation (Martin et al., 2000) at different stages of health and disease. Although there is such a wealth of research from many disciplines, the neuroanatomical aspects of plasticity are the focus of this paper. It seeks to illuminate the evolution of different concepts of plasticity concerning the structure and circuitry of the central nervous system (CNS). Early modern morphological research on de- and regeneration phenomena in the 19th- and early 20th-century is well documented. These studies, however, almost exclusively concentrated on the peripheral nervous system (PNS). It was one of the major contributions of Santiago Ramón y Cajal (1852–1934), that he applied the concept of regenerative capacities to the CNS. But the term plasticity seemed to have disappeared for about two decades after his death. The ensuing comeback of the expression may be attributed, at least in part, to new neuroanatomical staining and tracing methods. The pursuit of these techniques will serve as a guidepost through varying approaches in different times: It was the 1950s which seemed to spawn the time for new departures in structural investigations of neuronal plasticity.     

Evolution of the Concept of ‘Extracellular Matrix’ in the Brain

The question as to whether an extracellular matrix exists between cells in the adult brain has been debated since the end of the last century. In the early years, zones containing neuropil and glial processes were mistakenly believed to represent this substance. But Golgi's discovery of the “perineuronal net” paved the way for future study of the true extracellular matrix. In the 1950s, application of histochemical techniques established the existence of interstitial material between nerve cells. Unfortunately the similarity between the pericellular distribution of this material and Golgi's “pericellular nets” was overlooked. The detection of an extracellular volume fraction in the central nervous system furnished further indirect proof for the existence of an extracellular matrix in the brain. However, the repeated failure of electron microscopy to reveal a substantial space between cell processes undermined the acceptance of the concept of “extracellular matrix” in the central nervous system. Nowadays this concept has, however, been firmly established.     

First archaeobotanical approach to plant use among Selknam hunter-gatherers (Tierra del Fuego, Argentina)

Diverse hunter-gatherer groups inhabited Tierra del Fuego (Argentina) from the end of the last glaciation until recent dates. Sadly, the contact with European settlers was fatal for them, and a series of different causes led to their disappearance. Among these groups, Selknam inhabited the central and northern part of the Isla Grande (Tierra del Fuego) until the first decades of twentieth century. Although many travellers and ethnographers described this society, the recorded information related to vegetal resources management and plant exploitation strategies was quite scarce. As a consequence, a picture was created in which plants, and especially plant food, had a very poor role in the everyday life of these people. In this work, we present the results of the first archaeobotanical analyses carried out on an excavated site related to the Selknam hunter-gatherers. The information presented here, along with future studies, will enlarge the knowledge and enrich the image that we have of Selknam’s plant use, economy and social relations.     

Practising Development at Home: Race,Gender, and the “Development” of the American South

Drawing on a range of works that extend from gendered historical analyses of colonialism to critical histories of development, and based on archival research in Alabama, Arkansas, and Mississippi, I argue in this paper that what we now call international development—a form of hegemony different from but related to colonialism—needs to be understood not only as a geopolitical tool of the Cold War, but also as a technique of governance that took shape within the realm of the domestic and through a racialized gaze. I do so by tracing some of the key elements of the US international development practices in the postwar era to a different time and place: the American South, a region considered “undeveloped” in the first decades of the twentieth century, and the agricultural extension practices that targeted the rural farm home and farm women, particularly African‐American women.     

Gender and daily mobility in a New Zealand city, 1920–1960

Although it is widely accepted that transport—like other social practices—is gendered, the concept of gender used in transport research is often one‐dimensional, with the focus on gendered variations in behaviour rather than on gendered meaning and identities. In this paper, I develop a more complex and multi‐stranded way of approaching the issue of gender and transport (or rather, daily mobility). A case study of a neighbourhood in the New Zealand city of Dunedin in the early decades of last century is presented to explore how the practices of daily mobility constituted gender. A three‐part concept of gender is developed as a basis for analysis: gender as a pattern of social relations, a cultural system of meaning and a component of personal identity. This is then used to analyse a collection of sixty oral histories. The period 1920–1960 is particularly interesting; in these decades extensive and widely used public transport systems (notably electric trams) shared urban streets with bicycles and pedestrians, and the emerging private modes of motorcycle and motor car. As new transport technologies were taken up, they offered the opportunity for new social practices to be formed around their use, for cultural meanings to be assigned to the technologies and for embodied individual subjectivities to be constructed. I argue that we can usefully interpret the shifting patterns of transport use through the lens of gender, and that we can come to understand the process by which gender is constructed by attention to everyday trip‐making and presence on the street.     

Food and the middle ages

The study of food in the middle ages attracted much interest among antiquarians from the eighteenth century on. New perspectives came with the growth of social and economic history. Over the last two decades, re-evaluations of historical sources, along with contributions from other disciplines, especially archaeology, the archaeological sciences, anthropology and sociology, have changed the possibilities for this area of research. The study of cooking, of cuisine and its cultural context, as much as food production and the material conditions of life, is now central to developing our understanding of consumption. This paper explores new possibilities for the study of taste and demotic cuisine, food and virtue, the association of women with food, and the role of food in society and in cultural change.     

移动地理研究的一种理论框架——基于文献分析

移动性是21世纪人文地理的研究热点和重要议题,它体现了空间科学的社会学转向,属于人文地理学的核心概念和中心命题,其中心性突出体现在它与其他传统和新兴的人文地理分支学科的交叉。本文以表格为工具梳理了地理移动性的研究理路,发现移动地理与其他人文地理分支学科共同聚焦的核心是：时间地理、旅游地理、行为地理的“时空行为”问题,政治地理、社会地理的“权力”“平等”“权利”问题,身体地理的“具身实践”“感官体验”问题,情感地理的“地方依恋”“身份认同”问题,想象地理的“地方感”问题,道德地理的“空间道德感”问题。本文识别这些关键问题为移动地理的“核心要素”,搭建移动地理的框架和体系,指出探查这些要素之间相互作用机制和不同时空移动类型的转化机理是未来移动性的研究方向。根据移动的空间尺度和时间强度,构建了包括日常移动、旅游和旅行移动到永久性移动在内的地理学移动性连续轴类型,并探索了移动地理研究的方法论体系。     

A History of the Concept of Spatial Autocorrelation: A Geographer's Perspective

Spatial autocorrelation is a concept that helps to define the field of spatial analysis. It is central to studies using spatial statistics and spatial econometrics. In this paper, we trace the early development of the concept and explain the academic links that brought the concept to the fore in the late 1960s. In geography, the importance of the work of Michael F. Dacey, Andrew D. Cliff, and J. Keith Ord is emphasized. Later, with the publication of a volume on spatial econometrics by Luc Anselin, spatial research and the use of the concept of spatial autocorrelation received a considerable boost. These developments are outlined together with comments about recent and possible future trends in spatial autocorrelation-based research.     

Geoffrey Holmes and the Urban World of Augustan England

Urban history as a sub-discipline within history began to emerge in Britain in the 1960s and early 1970s. Attention initially focused heavily on the 19th century, but the Tudor and early Stuart town also soon attracted attention. Academic interest in the post-restoration and 18th-century urban world emerged a little more slowly, but the closing decades of the 20th century produced a mounting volume of research on the subject. Geoffrey Holmes was one of a group of post-war historians rewriting the history of Augustan Britain and re-establishing its significance in the longer-term development of the country. Though not a specialist urban historian, Holmes saw towns playing a vital part in shaping the character of the period. His research anticipated and inspired many of the facets of the rapidly-emerging historiography on the 18th-century town, intersecting with it in three particular areas. First, in demonstrating the important role played by towns, in particular as the home of four-fifths of the seats in the house of commons, in the broader political system; second, in highlighting the position of London at the hub of the Augustan world; and third in revealing the part played by towns, and especially those who inhabited them, in promoting social change at the same time as securing long-term political stability.     

The Evolution of the Pre-Confucian Meaning of Jen 仁 and the Confucian Concept of Moral Autonomy

Abstract

Once ostracized and relegated to a mere marginal position in the history of modern Chinese literature, Lin Shu 林紓 (1852–1924) has now become an important and relatively well-known figure. This paper summarizes existing research on Lin Shu's translations and the controversy between the vernacular and the classical language, emphasizing the achievements of Chinese and Japanese scholarship during the past century. For practical reasons, results have been divided chronologically into four categories: (1) Criticism of Lin Shu before 1924; (2) Early Chinese Scholarship (1924–1935); (3) Late Chinese and Early Japanese Scholarship (1935–1960); (4) Renaissance of Studies on Lin Shu outside China (1960–2000). This periodization is supplemented with a brief excursus on the current state of Lin Shu studies.     

Clothing the Poor in Early-Nineteenth-Century England

Abstract

In a pioneering study in this journal, Steven King suggested that parish clothing provision was of fundamental importance in the eighteenth century both in terms of local social relations and the perceived standing of parish authorities. This article tests his thesis for the first decades of the nineteenth century, confirming that parish clothing was indeed pivotal in maintaining a sense of local social justice. However, it takes issue with King's reasons for the relatively high levels of clothing provision enjoyed by the poor, suggesting that they had as much to do with a set of shared values between giver and receiver as they did with considerations of parish prestige or social order.     

Origins of molecular neurobiology: the role of the physicists

The revolution in the foundations of physics at the beginning of the twentieth century suggested to several of its most prominent workers that biology was ripe for something similar. In consequence, a number of physicists moved into biology. They were highly influential in initiating a molecular biology in the 1950s. Two decades later it seemed to several of these migrants, and those they had influenced, that the major problems in molecular biology had been solved, and that it was time to move on to what seemed to them the final problem: the nervous system, consciousness, and the age-old mind-body problem. This paper reviews this "double migration" and shows how the hopes of the first generation of physicist-biologists were both realized and dashed. No new physical principles were discovered at work in the foundations of biology or neuroscience. On the other hand, the mind-set of those trained in physics proved immensely valuable in analyzing fundamental issues in both biology and neuroscience. It has been argued that the outcome of the molecular biology of the 1950s was a change in the concept of the gene from that of "a mysterious entity into that of a real molecular object" (Watson, 1965, p.6); the gates and channels which play such crucial roles in the functioning of nervous systems have been transformed in a similar way. Studies on highly simplified systems have also opened the prospect of finding the neural correlatives of numerous behaviors and neuropathologies. This increasing understanding at the molecular level is invaluable not only in devising rational therapies but also, by defining the material substrate of consciousness, in bringing the mind-body problem into sharper focus.     

Oral/Past Culture and Modern Technical Means in the Literature of the Twentieth Century in Greenland

Abstract

The present article takes as its starting point a short story from 2001 and relates it to the development of the Greenlandic literature in the twentieth century. The Greenlandic literature evolved around 1900 and mirrors the socio-political trends and the stages of nation building through the twentieth century. The overall tendencies of the century start with a striving towards more knowledge of and competence in European culture (including technical know-how) before 1950. Then a feeling of overwhelming impact from Danish culture followed during the Danification policy of the 1950s, 1960s and 1970s and this resulted in a protest movement in the 1960s and 1970s and Home Rule from 1979. However, if we read the literature in details and supplement it with the contemporary newspapers a much more diverse picture of an appropriation process (i.e. a conscious adaptation of selective parts of the impact from outside) emerges. The present article focuses on how these sources give us glimpses of an ongoing debate already in the first half of the twentieth century i.e. in colonial times: the Greenlandic population was not just passively under colonial domination. The history of the twentieth century is the history about a fairly well functioning appropriation of technical means and cultural impact from outside up till 1950, and then – after three decades of heavy modernization and Danification –-a process from 1979 on towards more and more agency in a “ glocalized” Greenland.