An early illustrated comparative anatomy of the brain: Samuel Collins' A Systeme of Anatomy (1685) and the emergence of comparative neurology in 17th century England

The concept of comparing of the brains of various animals and of individual human brains was launched in the last half of the 17th century in England and was much influenced by the formation of the European scientific societies and their attempts to guide naturalist observations into a new systematics. An ambitious attempt to document this trend in an extensively illustrated work of encyclopedic pretensions was the singular publication of Samuel Collins (1618-1710), an energetic anatomist and president of the Royal College of Physicians. His little known tow-volume folio presentation, written in teh vernacular for broad acceptance, contains the seeds of a science of comparative neurology with the largest collection of brain illustrations (as well as of other organ systems) attempted in his era. Although lacking the conceptual insight that might derive from a true "comparative" anatomy and an understanding of the relations of different animals, the handsome engravings exemplified the new direction of the 'enlightenment' of the scientific revolution and are discussed in teh context of relevant events of this period.     

An Early Illustrated Comparative Anatomy of the Brain: Samuel Collins’ A Systeme of Anatomy (1685) and the Emergence of Comparative Neurology in 17th Century England

The concept of comparing of the brains of various animals and of individual human brains was launched in the last half of the 17th century in England and was much influenced by the formation of the European scientific societies and their attempts to guide naturalist observations into a new systematics. An ambitious attempt to document this trend in an extensively illustrated work of encyclopedic pretensions was the singular publication of Samuel Collins (1618–1710), an energetic anatomist and president of the Royal College of Physicians. His little known two-volume folio presentation, written in the vernacular for broad acceptance, contains the seeds of a science of comparative neurology with the largest collection of brain illustrations (as well as of other organ systems) attempted in his era. Although lacking the conceptual insight that might derive from a true “comparative” anatomy and an understanding of the relations of different animals, the handsome engravings exemplified the new direction of the ‘enlightenment’ of the scientific revolution and are discussed in the context of relevant events of this period.     

The White Paper: Wilder Penfield,the Stream of Consciousness,and the Physiology of Mind

ABSTRACT

Wilder Penfield is justly famous for his contributions to our understanding of epilepsy and of the structure-function relationship of the brain. His theory on the relationship of the brain and mind is less well known. Based on the effects of the electrical stimulation of the cortex in conscious patients, Penfield believed that consciousness and mind are functions of what he referred to as the centrencephalic integrating system. This functional system comprised bidirectional pathways between the upper brainstem, the thalami, and the cerebral cortex of both hemispheres, and was the physical substrate from which memory, perception, initiative, will, and judgment arose. It was the source of the stream of consciousness and the physical basis of mind. This paper reviews how Penfield arrived at this conception of the mind-brain relationship. Although Penfield ultimately felt that he had failed in his attempt to unify brain and mind, his work shed new light on the relationship of memory to the mesial temporal structures and to the temporal cortex; and his association of consciousness and the brainstem preceded the conceptualization of the reticular activating system by a generation. In these, as in so many aspects of neurobiology, Penfield was prescient.     

Drawing,Etching, and Experiment in Christopher Wren’s Figure of the Brain

Abstract

Christopher Wren’s figure of the brain ‘viewed from below’ in Thomas Willis’s Cerebri anatome (1664) set a precedent, not only for subsequent images of the brain, but for scientific illustration. The image is the visual proof of a Baconian experiment conducted by the Oxford dissection team, in which dye was pumped into the carotid arteries of animal and human specimens in order to imitate the natural flow of blood, thereby applying William Harvey’s theory of circulation to the brain. Usually described as engravings, Wren’s images are in fact etchings (produced by the acid process), significant because etching for book illustration was then in its infancy in England. In addition to considering Wren as an experimental etcher, this article frames our understanding of Wren’s contributions to Willis’s project in terms of his virtuosic talents as amateur draughtsman, natural historian, anatomist, and his use of optical and draughting instruments.     

Domus Willisi: a neuro-architectural tour

Fifteen sites in England today can be identified with Dr. Thomas Willis, the Oxford physician and anatomist, who was the founder of neurology. Four of these were domiciles; Beam Hall, where Willis and his colleagues met to study the brain and nerves, can be claimed as the first Neurological Institute. The last dwelling place of Willis is Westminster Abbey, where in 1961 his memorial stone was renewed by neurologists and neurosurgeons. Part of this original stone marks the new Brain Imaging Centre at the Montreal Neurological Institute, where the name of Thomas Willis shares a place in the Hall of Neurological Fame.     

Domus Willisi: A Neuro‐Architectural Tour*

Abstract

Fifteen sites in England today can be identified with Dr. Thomas Willis, the Oxford physician and anatomist, who was the founder of neurology. Four of these were domiciles; Beam Hall, where Willis and his colleagues met to study the brain and nerves, can be claimed as the first Neurological Institute. The last dwelling place of Willis is Westminster Abbey, where in 1961 his memorial stone was renewed by neurologists and neurosurgeons. Part of this original stone marks the new Brain Imaging Centre at the Montreal Neurological Institute, where the name of Thomas Willis shares a place in the Hall of Neurological Fame.     

2. ONCE AGAIN,WITH MORE FEELING

This book summarizes in a compact volume Runciman's arguments to comparative sociologists that their discipline belongs under the theoretical umbrella of neo‐Darwinian selectionism. In his view, heritable variation and competitive selection govern cultural and social as well as biological evolution. Runciman makes a strong case for the usefulness of selectionism, but two of the theory's central features are problematic: his choice of units of selection; and the notion that culture can be distinguished from society historically as well as analytically. No one friendly to the basic project would argue against the need for hypotheses about units that undergo selection, but arguments can be made, also on pragmatic grounds, that he has chosen the wrong kinds of units. Runciman's learning and wisdom show to good effect in the book's fundamental approach: in the overall human story, the biological, cultural, and social coevolve. The quickly accumulating evidence of evolutionary psychology, anthropology, sociology, and neuroscience strongly supports the hypothesis that there is a biological basis for a great deal of human behavior, and also that sociocultural evolution modifies genes. History, in this way of thinking, is like a “braided stream” of unpredictably mutating, blending, and coevolving biological, cultural, and social processes. The old Darwinian image of branching fails to capture the complexity of evolutionary processes in biology, culture, and society. Runciman outlines a unified bio‐social science relying upon information theory. If his program were carried out consistently it would relegate to a non‐scientific level the traditional historical narratives about “carriers” or “vehicles”. The scientific‐explanatory level would instead feature replicators. Gametheory strategies play a prominent role in the selectionist picture. The emphasis on units of information stored in human brains or in exosomatic brain prostheses pushes neuroscience and information theory to the fore. An argument for the analytic‐heuristic value of “memes” and “practices” should be weighed against the value of other hypothetical units undergoing selection in a sociocultural evolutionary approach.     

WHERE NEUROSCIENCE GETS THINGS WRONG (AND RIGHT)

Alex Rosenberg's book How History Gets Things Wrong holds that our attachment to history as a vehicle for understanding has a long evolutionary pedigree and a genetic basis, but this vehicle involves a defective theory of human nature because it involves a defective theory of the brain as shown by neuroscience. Reviewing his arguments, I argue that our attachment (if any) to history as a vehicle of understanding is not an inherited characteristic as evolutionary theory, if relevant, would require, but is developed culturally. I also argue that an evolutionary basis for a cognitive capacity does not undermine its reliability as a vehicle of knowledge or understanding. Moreover, evolutionary theory and neuroscience are separable theories, and neuroscience is misused and misunderstood by Rosenberg. Rosenberg holds that neuroscience provides a better theory of mind than does the “theory of mind” used by historians (as he understands them), where the latter is assumed by him to involve explaining by reference to beliefs and desires. However, Rosenberg illegitimately adopts what philosophers of mind call “theory‐theory” to characterize historians' assumptions and does not recognize that neuroscience need not be conceived as a rival theory of explanation of action. He wrongly supposes that historical narratives are essentially explanations of individual action. A better use of neuroscience is to learn that “imagining the past” and “imagining the future” use the same brain processes, and just as imagining the future has no causal chain linking the relevant brain states directly to reality, so we have no reason to think that “imagining the past” does. Getting our imaginings correct requires sound historiographical expertise.     

Gender, nature, empire: women naturalists in nineteenth century British travel literature

Among the many British women abroad in the late nineteenth century were a number of travellers who toured the American West with a naturalist's pen and sketchbook. California, with its giant sequoias and redwoods, scenic Yosemite Valley and Sierra Nevada, and the Mediterranean flora of the southern coasts, especially attracted travellers with a naturalist orientation. We examine the botanical and naturalist writings and art of two well-known (and well-heeled) world travellers – Constance Gordon Cumming and Marianne North – and another more obscure British aristocrat, Theodora Guest, sister of the Duke of Westminster, who travelled in California in the late nineteenth century. We examine relationships among these elite women's association with the Romantic aesthetic and naturalist traditions, natural sciences, class-based associations between women and flowers, and emergent environmentalism. The works of these women indicate the process by which natural history rhetorics and styles became embedded within gender, class, and imperial relations; and how the division of natural history into professional and amateur domains relegated women to discursive margins.     

The impossible interview with the man of the hidden biological structures. Interview by Paolo Mazzarello

This paper presents an "impossible interview" to Professor Camillo Golgi, placed in time in December 1906. The Italian Professor Golgi from Pavia has been awarded the Nobel Prize for Physiology or Medicine ex aequo with the Spanish anatomist Santiago Ramón y Cajal. Both scientists have obtained the award for their work on the anatomy of the nervous system. However, they have opposite views on the mechanisms underlying nervous functions. Golgi believes that the axons stained by his "black reaction" form a continuous anatomical or functional network along which nervous impulses propagate. Ramón y Cajal is the paladin of the neuron theory, a hypothesis questioned by Golgi in his Nobel lecture of Tuesday, December 11. After the ceremony, an independent journalist has interviewed Professor Golgi in the Grand Hotel in Stockholm. Excerpts about his education, his main scientific discoveries, and his personal life are here given (reconstructing the "impossible interview" on the basis of Golgi's original writings).     

The Central Institute for Brain Research in Amsterdam and its Directors

The Central Institute for Brain Research was founded in Amsterdam in 1908 as part of an international effort to study the nervous system with multiple institutions and various disciplines. The development of research in the past hundred years at the Brain Institute has hardly been documented. We analyze the history of this institute by means of brief portraits of its directors and their main research topics. It appears that each director introduced his own branch of neuroscience into the institute. Initially, mainly comparative neuroanatomical data were collected. Following the Second World War, the multidisciplinary approach slowly developed with research programs on systems neuroscience, neuroendocrinology, and brain disorders. Every new director introduced new approaches to the study of the brain and thus played an important role in keeping brain research in the Netherlands at the international forefront where it has been ever since its foundation in 1908.     

The Neurophysiological Aspects of Pavlov’s Theory of Higher Nervous Activity: In Honor of the 150th Anniversary of Pavlov’s Birth

Whereas Ivan P. Pavlov (1849-1936) is well-known for his work on classical conditioning, his contribution to neuroscience, particularly his interest in the function of neural centers in the central nervous system, is not as widely known. During the last three decades of his life, Pavlov explored cortical processes by salivary reflex conditioning, a method he used to develop his theory of higher nervous activity. This theory outlined the function of the brain in higher organisms in their interaction with the changing environmental contingencies. As early as 1908, Pavlov outlined a neurophysiological theory as the physiological basis of his theory of higher nervous activity. He maintained that the neural processes of excitation and inhibition irradiate and concentrate among the cortical neural centers. Most of all, he emphasized the plasticity of the cortex in higher organisms’ in the Darwinian struggle for existence.     

Franz Joseph Gall on hemispheric symmetries

ABSTRACT

Franz Joseph Gall believed that the two cerebral hemispheres are anatomically and functionally similar, so much so that one could substitute for the other following unilateral injuries. He presented this belief during the 1790s in his early public lectures in Vienna, when traveling through Europe between 1805 and 1807, and in the two sets of books he published after settling in France. Gall seemed to derive his ideas about laterality independently of French anatomist Marie François Xavier Bichat (1771–1802), who formulated his “law of symmetry” at about the same time. He would, however, later cite Bichat, whose ideas about mental derangement were different from his own and who also attempted to explain handedness, a subject on which Gall remained silent. The concept of cerebral symmetry would be displaced by mounting clinical evidence for the hemispheres being functionally different, but neither Gall nor Bichat would live to witness the advent of the concept of cerebral dominance.     

The neurophysiological aspects of Pavlov's theory of higher nervous activity: in honor of the 150th anniversary of Pavlov's birth

Whereas Ivan P. Pavlov (1849-1936) is well-known for his work on classical conditioning, his contribution to neuroscience, particularly his interest in the function of neural centers in the central nervous system, is not as widely known. During the last three decades of his life, Pavlov explored cortical processes by salivary reflex conditioning, a method he used to develop his theory of higher nervous activity. This theory outlined the function of the brain in higher organisms in their interaction with the changing environmental contingencies. As early as 1908, Pavlov outlined a neurophysiological theory as the physiological basis of his theory of higher nervous activity. He maintained that the neural processes of excitation and inhibition irradiate and concentrate among the cortical neural centers. Most of all, he emphasized the plasticity of the cortex in higher organisms' in the Darwinian struggle for existence.     

Variety and Adventure in the Life of Carl Linden

Abstract

In his long life Carl Linden lived variously and wonderfully. For more than half a century he was a teacher and promoter of Great Books in the classroom and in the neighborhood. Great Books in his hands and mind transformed him into a kind of latter-day Socrates, always questioning, always smiling, sometimes teasingly. As a naturalist he was a hiker/biker on the C&O Canal towpath and promoter of it, as well. His scholarly pursuits took him to Eastern Europe, especially to Russia and Ukraine, about which he wrote and taught for four decades. Finally, he was a bon vivant whose Socratic ways won him laurels in the classroom and friends in the places where good fellows meet.     

Vesalius on the Anatomy and Function of the Recurrent Laryngeal Nerves: Medical Illustration and Reintroduction of a Physiological Demonstration from Galen

The purpose of this article is to review the anatomical illustrations and physiological demonstrations of sixteenth-century Flemish-born anatomist and physician Andreas Vesalius concerning the recurrent laryngeal nerves. Although Vesalius was primarily an anatomist, he also used vivisection as a pedagogical device to help his students understand the function of structures within the fabric of the body that they had previously studied in anatomical detail. Vesalius’s masterwork, De humani corporis fabrica or simply the Fabrica (1543, 1555), was ostensibly an anatomy text, but Vesalius included textual and figural references to his use of vivisection to explicate the function of specific structures. Even as he began to criticize the errors in Galen’s anatomical works, Vesalius nevertheless adopted some of Galen’s classic physiological demonstrations, in particular the ligation (and subsequent release) of the recurrent laryngeal nerves of a pig to demonstrate their role in generating the pig’s squeal. Vesalius’s illustrations concerning the recurrent laryngeal nerve in the Fabrica were of two types: elegant anatomical woodcut plates—unsurpassed for their clarity, accuracy, and detail — and the distinctly inelegant historiated initial Q, depicting a throng of putti busily engaged in vivisecting a pig. Vesalius’ anatomical plates were heavily plagiarized while the historiated initials, showing the rough work of an anatomist or surgeon, were largely ignored and remain little recognized today. While Vesalius’ anatomical illustrations of the recurrent laryngeal nerves contained some errors, they were a dramatic departure from prior meager efforts at medical illustration and indeed far surpassed all contemporary published illustrations by others. Vesalius was also influential in reviving Galen’s approach to vivisection, at least for pedagogical purposes, if not really then yet as a full-fledged investigative technique.     

„Die Photographie als Hülfsmittel mikroskopischer Forschung”︁? Joseph von Gerlach (1820–1896) und die frühen anatomischen Mikrophotographen

The Erlangen anatomist Joseph von Gerlach was one of the first medical researchers who used microphotography for their scientific aims in basic tissue research. Already in 1863, Gerlach published a famous handbook on the methodology of the microphotographic technique, entitled Die Photographie als Hülfsmittel mikroskopischer Forschung. Here, he discussed the technological, practical and epistemological standards and constraints of the newly introduced visualisation technique of scientific photography. The efforts and setbacks of Gerlachs' innovative approaches shall be characterised in the present paper. Furthermore, some of the most important arguments put forward by some of his peers are closely compared and thoroughly scrutinised. These anatomical and biological microscopists objected frequently to Gerlach's photographic approach as being "unscientific" or "insufficient" to support the growth of experimental morphology and neurohistological research. In his scientific self-defence, Gerlach developed important auxiliary arguments that display many facets of the epistemological discourse of 19th-century medical research, particularly on the question of how scientific objects should be visualised and identified in the experimental laboratory.