Origins of Molecular Neurobiology: The Role of the Physicists

The revolution in the foundations of physics at the beginning of the twentieth century suggested to several of its most prominent workers that biology was ripe for something similar. In consequence, a number of physicists moved into biology. They were highly influential in initiating a molecular biology in the 1950s. Two decades later it seemed to several of these migrants, and those they had influenced, that the major problems in molecular biology had been solved, and that it was time to move on to what seemed to them the final problem: the nervous system, consciousness, and the age-old mind-body problem. This paper reviews this “double migration” and shows how the hopes of the first generation of physicist-biologists were both realized and dashed. No new physical principles were discovered at work in the foundations of biology or neuroscience. On the other hand, the mind-set of those trained in physics proved immensely valuable in analyzing fundamental issues in both biology and neuroscience. It has been argued that the outcome of the molecular biology of the 1950s was a change in the concept of the gene from that of “a mysterious entity into that of a real molecular object” (Watson, 1965 Watson, JD. 1965. The Molecular Biology of the Gene, New York: Benjamin.  [Google Scholar], p.6); the gates and channels which play such crucial roles in the functioning of nervous systems have been transformed in a similar way. Studies on highly simplified systems have also opened the prospect of finding the neural correlatives of numerous behaviors and neuropathologies. This increasing understanding at the molecular level is invaluable not only in devising rational therapies but also, by defining the material substrate of consciousness, in bringing the mind-body problem into sharper focus.     

Kant and the scientific study of consciousness

We argue that Kant's views about consciousness, the mind-body problem and the status of psychology as a science all differ drastically from the way in which these topics are conjoined in present debates about the prominent idea of a science of consciousness. Kant never used the concept of consciousness in the now dominant sense of phenomenal qualia; his discussions of the mind-body problem center not on the reducibility of mental properties but of substances; and his views about the possibility of psychology as a science did not employ the requirement of a mechanistic explanation, but of a quantification of phenomena. This shows strikingly how deeply philosophical problems and conceptions can change even if they look similar on the surface.     

Representation and identity - convergence of brain research and mind-brain philosophy

The localization or representation of mental abilities in the brain have always been considered as key questions for understanding the organization of the human nervous system. Particularly with the advent of modern electrophysiological and imaging techniques that provide maps of electromagnetic fields and metabolic processes on the living central nervous system, the representation theory is experiencing a scientific renaissance in neurology, but is only one theory, however, in the succession of a long philosophical tradition dealing with the possible identification of mental phenomena and brain processes. This dichotomy was formulated at the latest in the Cartesian dualism of res cogitans and res extensa of the mind-body problem. Nowadays philosophical discussion, on the contrary, is dominated by monistic concepts that attempt to explain the mental realm on an organic foundation in order not to succumb to the problem of a psychophysical dualism. Of these, the identity theory offers a philosophically plausible concept postulating that the identity of brain conditions and mental phenomena is based on organic foundations. In this theory, the efforts of brain research converge on the representations of mental phenomena in the human nervous system. In a comprehensive approach, both concepts could complement each other.     

Interdisciplinarity in the neurosciences

Abstract

The study of the human brain and of the biological nature of the mind and consciousness remains one of the greatest of all scientific challenges. Neuroscience can also lay claim to being one of the most interdisciplinary fields of scientific enquiry, and this has been true since well before the concept of interdisciplinarity was itself invented. Neuroscience draws on insights and developments in disciplines as diverse as molecular biology, electronics, biomedical engineering, statistics, psychology, biophysics, pharmacology, and linguistics. This paper examines the historical, transdisciplinary roots of modern neuroscience and reviews its contemporary interdisciplinary character, before examining two 'case studies', the emergence of functional neuroimaging as a powerful new neuroscientific tool and the ongoing dialogue between computer science and the neurosciences.     

邓小平“一国两制”构想的形成与发展

"一国两制"构想是邓小平理论中最具有创新意义的内容之一."一国两制"构想孕育于20世纪50、60年代,周恩来对毛泽东关于和平解决台湾问题的思想所作的概括即"一纲四目",是邓小平"一国两制"构想的直接思想渊源.从党的十一届三中全会前后邓小平提出和平解决台湾问题思想,到1984年5月第六届全国人民代表大会第二次会议确认"一国两制"的构想,使之成为一种具有法律效力的基本国策,是邓小平"一国两制"构想的形成阶段.1984年6月以后,邓小平"一国两制"构想又得到了进一步丰富和发展.而且由理论变为法律、变为实践.     

The impossible interview with the man of the neuron doctrine. Interview by Edward G Jones

This paper follows the form of that by Mazzarello that precedes it (Mazzarello, 2006) and presents an imaginary interview with Santiago Ramón y Cajal in December 1906. A few days earlier Cajal had been awarded the Nobel Prize for Physiology or Medicine, an award that he shared equally with Professor Camillo Golgi. Golgi had been recognized for his work as a pioneer into investigations of the nervous system, primarily on account of his discovery of the "black reaction" of silver chromate impregnation of whole nerve cells and their processes. Cajal had been recognized for his implementation of that method and for laying with it the foundations of what was to become modern neuroanatomical science. Paradoxically, the two awardees had been led by their researches to diametrically opposed views of the organization of the nervous system. Golgi believed in a continuous network of axons that formed the basis of all the integrative properties of the nervous system, while Cajal had provided the information that led to the formulation of the neuron doctrine that saw the nervous system as being made up of chains of discontinuous cells joined by polarized functional contacts that we now call synapses. The paper takes the form of an interview with Professor Cajal in the Grand Hotel Stockholm. His responses to questions posed by the imaginary interviewer are all taken from Cajal's own writings.     

The Moscow Colloquium on Electroencephalography of Higher Nervous Activity and its impact on international brain research

Late 1950s was a period of recognition of Russian neurophysiology by international neuroscience community and vice versa. This process of "opening windows in both directions" might be illustrated by the story of The Moscow Colloquium on Electroencephalography of Higher Nervous Activity. The Colloquium took place on October 6-11, 1958 at the House of Scientists in Moscow. It was organized by the Academy of Sciences of the USSR under the initiative of the Institute for Higher Nervous Activity and focused on (a) EEG correlates of cortical excitation and inhibition; (b) electrophysiological study of different brain structures and their role in conditioned reflexes; and (c) EEG of higher nervous activity in humans. At the final session it was suggested to launch an International Year for the Study of the Brain and to ask UNESCO for international coordination of brain research. This resulted into the International Brain Research Organization (IBRO) founded in 1960. This article is based on unpublished records of international contacts of Soviet neurophysiologists and organization of the Moscow Colloquium from the Archive of Russian Academy of Science (ARAN), reports in Soviet periodicals, publications in obscure Festschriften, etc.     

The Central Institute for Brain Research in Amsterdam and its Directors

The Central Institute for Brain Research was founded in Amsterdam in 1908 as part of an international effort to study the nervous system with multiple institutions and various disciplines. The development of research in the past hundred years at the Brain Institute has hardly been documented. We analyze the history of this institute by means of brief portraits of its directors and their main research topics. It appears that each director introduced his own branch of neuroscience into the institute. Initially, mainly comparative neuroanatomical data were collected. Following the Second World War, the multidisciplinary approach slowly developed with research programs on systems neuroscience, neuroendocrinology, and brain disorders. Every new director introduced new approaches to the study of the brain and thus played an important role in keeping brain research in the Netherlands at the international forefront where it has been ever since its foundation in 1908.     

William James on a phenomenological psychology of immediate experience: the true foundation for a science of consciousness?

Throughout his career, William James defended personal consciousness. In his "Principles of Psychology" (1890), he declared that psychology is the scientific study of states of consciousness as such and that he intended to presume from the outset that the thinker was the thought. But while writing it, he had been investigating a dynamic psychology of the subconscious, which found a major place in his Gifford Lectures, published as "The Varieties of Religious Experience" in 1902. This was the clearest statement James was able to make before he died with regard to his developing tripartite metaphysics of pragmatism, pluralism and radical empiricism, which essentially asked "Is a science of consciousness actually possible?" James's lineage in this regard, was inherited from an intuitive psychology of character formation that had been cast within a context of spiritual self-realization by the Swedenborgians and Transcendentalists of New England. Chief among these was his father, Henry James, Sr., and his godfather, Ralph Waldo Emerson. However, james was forced to square these ideas with the more rigorous scientific dictates of his day, which have endured to the present. As such, his ideas remain alive and vibrant, particularly among those arguing for the fusion of phenomenology, embodiment and cognitive neuroscience in the renewed search for a science of consciousness.     

Evolution of the concept of "extracellular matrix' in the brain

The question as to whether an extracellular matrix exists between cells in the adult brain has been debated since the end of the last century. In the early years, zones containing neuropil and glial processes were mistakenly believed to represent this substance. But Golgi's discovery of the "perineuronal net" paved the way for future study of the true extracellular matrix. In the 1950s, application of histochemical techniques established the existence of interstitial material between nerve cells. Unfortunately the similarity between the pericellular distribution of this material and Golgi's "pericellular nets" was overlooked. The detection of an extracellular volume fraction in the central nervous system furnished further indirect proof for the existence of an extracellular matrix in the brain. However, the repeated failure of electron microscopy to reveal a substantial space between cell processes undermined the acceptance of the concept of "extracellular matrix" in the central nervous system. Nowadays this concept has, however, been firmly established.     

THE EMPIRICAL STRUCTURE OF URBAN SYSTEMS: THE LONDON, ONTARIO, EXAMPLE

S ince the early 1950s there have been numerous studies which have attempted to determine the hierarchical structure of urban-place systems. Although Harris and Ullman identified three general city-forming functions, namely central place, transportation, and specialized, most urban-place system studies since have been based on a measure of the central-place function. Pred emphasizes the problem in his recent work, City Systems in Advanced Economies. He used the term "city systems" because his study is of the complete system and not just the central-place portion of the system. I chose for this study the term "urban-place system" for the same reason, but used "urban-place" rather than "city" because the system contains towns, villages, and hamlets as well as cities.     

Between clinical medicine and the laboratory: medical research funding in France from 1945 to the present

By focusing on funding methods, this paper considers the way in which medical research eventually led to the science-based medicine that is prevalent in France today. This process seems to have taken place in three stages during the second half of the twentieth century. In the 1940s and 1950s, two major events occurred. The first was the creation of a national health insurance fund in France, which opened up new reasons for, and ways of, funding medical research. The second was the development of antibiotics, which triggered a revival of clinical medicine. In the 1960s and 1970s, a proactive government science policy allowed the life sciences and medical research to come together in the wake of a burgeoning new science: molecular biology. Thus, in 1964, the creation of the National Health and Medical Research Institute (Institut national de la santé et de la recherche médicale or INSERM), destined to "molecularize" medical research, was seen as the fulfillment of the government's ambitious research policy. Today, with medicine irreversibly embedded in scientific and technical rationality, health has become a major issue in modern societies. This paper therefore touches on some of the key features of biomedical research, including the revival of funding systems for clinical research and the development of a system of research grants that was made possible by patient organizations and the creation of new funding agencies.     

Inclusiveness and coherency in the history of the neurosciences

The International Society for the History of the Neurosciences (ISHN) defines "neurosciences" broadly, and we want to encourage the widest possible range of scholarly approaches to our subject. However, this deliberate inclusiveness could potentially cause problems with internal coherency in our organization and in the scholarship that we are trying to create. In other words, we need to avoid the pitfalls of the internalist-externalist tension without losing the benefits of both perspectives. In fact, I think that there is a large and interesting "gray zone," where the boundary between these supposedly separate approaches is both artificial and porous. This should be one of the most rewarding intellectual domains for the study of neuroscience history, because our subject is always culturally loaded by the mind/body problem and by the assumptions that it entails. Of course, neuroscience history is also influenced by all of the other cultural and scientific aspects of the milieus in which it is conducted. Understanding neuroscience history in all of its multiple historical contexts will require the participation of a wide range of scholarly viewpoints. To keep ourselves coherent in the process, we will have to educate each other.     

关于郑州商城小型房基的几点认识

郑州商城房基最早发现于20世纪50年代,主要发现地点位于内城东北角的白家庄、外郭城西部的人民公园和内城北部的紫荆山铸铜作坊遗址内。目前发现的商城房基可以分为地面式、半地穴式和窖穴式三类。房基的形状有长方形、方形、圆形、不规则形等。但最常见的形状是长方形,有的房基在建造过程中或建造之后有举行祭祀礼仪的习俗。此外,本文还对郑州商城小型房基发现较少的原因进行了探讨。     

Alcohol and the family in Canada

In the context of the family in Western society, alcohol often has been viewed as a problem. This article traces how the use of beverage alcohol in Canada related to the family in the transition from the preindustrial to late-twentieth-century era. Powerful temperance movements in the nineteenth century, and divisive prohibition policies in the early twentieth, attempted to protect the material and moral health of the family. Although liquor laws and social attitudes became more open starting in the 1930s, the medicalized discourse on alcoholism in the 1940s and 1950s was linked to notions of the family. Liberalization of retail and on - premise sales of alcohol in the 1960s and 1970s attempted to portray moderate drinking by adults as "normal" family activity. In the last quarter of the century, a neotemperance movement, reacting to issue such as impaired and driving and teenage drinking, suggested that alcohol's relationship to the family remained highly ambiguous.     

Dynamic Interaction between Rigid Foundations on Multi-layered Stratum

This article concerns the cross-interaction problem among multi-foundations on a linearly viscoelastic medium at very small shear strains. In the analysis, the foundations are discretized into a number of sub square-elements. The dynamic response within each sub-element is described by the Green’s function, which is obtained by the Fourier-Bessel transform and the precise integration method. Incorporating the displacement boundary condition and the force equilibrium of the foundations, it obtains the dynamic impedance and compliance functions of the foundations. Extensive results for two rigid circular foundations placed at different separations are presented. Parametric studies are carried out on the dynamic interaction among adjacent foundations. Illustrative results for several closely spaced foundations are also illustrated.     

The historical origins of the vegetative state: Received wisdom and the utility of the text

The persistent vegetative state (PVS) is one of the most iconic and misunderstood phrases in clinical neuroscience. Coined as a diagnostic category by Scottish neurosurgeon Bryan Jennett and American neurologist Fred Plum in 1972, the phrase “vegetative” first appeared in Aristotle’s treatise On the Soul (circa mid-fourth century BCE). Aristotle influenced neuroscientists of the nineteenth and early-twentieth centuries, Xavier Bichat and Walter Timme, and informed their conceptions of the vegetative nervous system. Plum credits Bichat and Timme in his use of the phrase, thus putting the ancient and modern in dialogue. In addition to exploring Aristotle’s definition of the “vegetative” in the original Greek, we put Aristotle in conversation with his contemporaries—Plato and the Hippocratics—to better apprehend theories of mind and consciousness in antiquity. Utilizing the discipline of reception studies in classics scholarship, we demonstrate the importance of etymology and historical origin when considering modern medical nosology.     

An Element of Thought: Phosphorus and Mental Philosophy in the Nineteenth Century

Georges Cabanis (17571808), through his writings on the relation of the physical and moral, or psychological, aspects of man, left a legacy that made the study of mental activity a part of physiology. His views on the importance of phosphorus to the function of the brain thrust that element into a prominent stream of research that involved many investigators in several countries. Although that particular stream eventually dried up, its influence remained: by the beginning of the twentieth century basic medical science had become well set on studies of the mind-body relationship.     

Neuroscience and the fallacies of functionalism

Smail's "On Deep History and the Brain" is rightly critical of the functionalist fallacies that have plagued evolutionary theory, sociobiology, and evolutionary psychology. However, his attempt to improve on these efforts relies on functional explanations that themselves oversimplify the lessons of neuroscience. In addition, like explanations in evolutionary psychology, they are highly speculative and cannot be confirmed or disproved by evidence. Neuroscience research is too diverse to yield a single picture of brain functioning. Some recent developments in neuroscience research, however, do suggest that cognitive processing provides a kind of “operating system” that can support a great diversity of cultural material. These developments include evidence of “top-down” processing in motor control, in visual processing, in speech recognition, and in “emotion regulation.” The constraints that such a system may place on cultural learning and transmission are worth investigating. At the same time, historians are well advised to remain wary of the pitfalls of functionalism.     

Nikolai V. Konovalov (1900-1966): his role in the development of neurology and the creation of the Institute of Neurology of the Russian Academy of Medical Sciences

Nikolai V. Konovalov (1900-1966) has left a significant imprint in the history of Russian neuroscience. He was among the coryphaei of international and national neurology. Along with the large number of fundamental scientific papers that have determined several aspects of the development of neuroscience, his contribution has been equally important to the establishment and development of one of the distinguished Russian scientific centers - the Institute of Neurology of the Russian Academy of Medical Sciences, which he headed from 1948 until 1966.