The scientific commons in the marketplace: the industrialization of biomedical materials at the New England Enzyme Center, 1963–1980

This paper investigates the industrialization of biomedical materials at the New England Enzyme Center (NEEC) from its establishment as a federally supported biochemical resource center in 1964 through its demise and refashioning into several commercial biotech companies in the late 1970s. It sets this history within the long‐standing debate on the proper relation between science and American economic and political traditions. The NEEC sought to embody two aims that stood in tension: academic independence in knowledge production and the market‐driven interests of the biomedical industry. A clash of values ensued, but built on a particular notion of independence: scientists pragmatically accepted the primacy of the market in the age of the ‘federal research economy.’ The question became how to carve out a space for science and scientific values in the market – an intellectual position that some legal and economic scholars have referred to as a scientific commons. Even so, industry executives came to see the idea of a scientific commons and public knowledge as obstructive to industrial innovation. This paper argues that, as seen through the case of the NEEC, the ascendancy of market values and attitudes in the 1970s played a critical role in reconfiguring the science‐industry relationship and in ‘industrializing’ the life sciences. As illustration of this change, I look at a commercial firm – Genzyme – born out of NEEC’s dissolution.     

The Resinous Cargo of the Java Sea Wreck

A number of blocks of resinous materials were found in the cargo of a 12th‐ to 13th‐century shipwreck, discovered in the late 1980s in the Java Sea near the Indonesian islands of Sumatra and Java and excavated in 1996. These well‐preserved blocks presumably were trade materials used for religious, medicinal, cosmetic, decorative or practical purposes. Such materials, derived from plants and termed exudates, generally include frankincense, myrrh, ‘gum benjamin’, liquidambar, dragon's blood, dammar, copal and amber. The source of the cargo resin could not be determined from the site. Investigation by nuclear magnetic resonance (NMR) spectroscopy has revealed that the molecular structure corresponds to that of modern resin from the plant family Dipterocarpaceae, known in trade as dammar and closely resembling Group B copal and amber. Other molecular classes of exudates are excluded. Such materials are not present in the Middle East, which then cannot be their source. The NMR spectra differ from those of Group B samples from Australia, Papua New Guinea and Indonesia, but resemble those from India or Japan. The spectra indicate that the saline environment had a similar effect on the molecular structure to heating and aging.     

The Copper CHARM Set: A New Set of Certified Reference Materials for the Standardization of Quantitative X‐Ray Fluorescence Analysis of Heritage Copper Alloys*

This paper introduces a new set of certified reference materials designed to aid scientists and conservators working in cultural heritage fields with quantitative X‐ray fluorescence analysis of historical and prehistoric copper alloys. This set has been designated as the Copper CHARM Set (Cultural Heritage Alloy Reference Material Set). The Copper CHARM Set is designed to be used by a wide range of museum‐, art‐ and archaeology‐oriented scientists and conservators to help improve the accuracy and range of their calibrations for quantitative ED–XRF spectrometry of copper alloys, and also increase the number of elements that can routinely be quantified. In addition, the common use of a single core set of the reference materials is designed to significantly improve inter‐laboratory reproducibility, allowing greater data sharing between researchers and thus furthering possibilities for collaborative study.     

Network Location and Policy‐Oriented Behavior: An Analysis of Two‐Mode Networks of Coauthored Documents Concerning Climate Change in the Great Lakes Region*,†

This study explores how a scientist's location in science‐based policy networks can affect her policy‐oriented behaviors. In particular, we hypothesize that those scientists who fill structural holes in their networks will be more likely than others to engage in policy‐oriented behaviors. The network data are defined by scientists' coauthorship on policy documents regarding climate change in the Great Lakes. We employ a two‐mode network analysis to identify clusters of scientists who coauthored similar documents, and relative to those clusters, we identify those who fill structural holes by bridging between clusters. We find that those scientists who bridged between clusters were more likely to engage in policy‐oriented behaviors of policy advocacy and advising than were others in the network. This is an example of a link between network location and policy‐oriented behavior indicative of the broader phenomenon of how individuals exert agency, given structural constraints.     

The Exact Men of the North from Tool Makers to Historians

Abstract

This account of northern social scientists, historians, and machine-tool and astronomical instrument makers carries forward the author's construction of an intellectual profile of the North of England in previous articles. Principally by analysing entries in relevant biographical dictionaries, the author has demonstrated that northerners of distinction have been disproportionately numerous among 'men of science' in general and machine-tool engineers and astronomical instrument makers in particular, and — at least since the eighteenth century — among musicians and historians. Astronomical instrument makers and machine-tool engineers were above all exact men; so were the 'new' (scientific) historians like Stubbs and Mandell Creighton who followed the research methods of Leopold von Ranke; while the musicians produced in symphonies and oratorios exactly dovetailed, multi-layered structures of sound. A distinction is drawn between two forms of exactness: one of 'correspondence', the other of 'coherence'. The contrasted social contexts in which they are likely to arise are discussed. Musicians and historians (whose exactness lay in 'coherence') were big-city men; astronomical and mathematical instrument makers were more likely to have come down from the hills. The final result: the North was strongly represented in the front ranks of the nation's historians, mechanical engineers, and musicians; with only weak representation in the foremost ranks of social scientists and imaginative writers.     

Scientific Credibility,Disagreement, and Error Costs in 17 Biotechnology Policy Subsystems

One of the original objectives of the advocacy coalition framework (ACF) was to shed light on the role of science in policymaking. The ACF depicts subsystem scientists as political actors just like any other. Unfortunately, science has never become a major theme of research within the framework and, as a consequence, its role in policymaking remains under‐theorized, leaving ample room for interpretation. This article seeks to explore the validity of three propositions about the role of science in policy. The first two are derived from the ACF: (i) the capacity of scientists to provide credible advice is affected by the harshness of the political debates dividing the policy subsystem; and (ii) agreement among scientists is just as common as among other groupings of policy actors. The third is derived from an “error costs” argument: (iii) Disagreements among scientists are even more pronounced than disagreements among other policy actors. Using the results of a survey of policy actors in 17 biotechnology subsystems, this article finds support for the first and third propositions. Indeed, scientists' participation in political divisions might even be underestimated by the ACF. The article concludes with attempts to clarify the role of scientists within the ACF, including discussions of ambiguity regarding the role of professional forums and of scientists in between‐coalition learning within policy subsystems.     

How China Navigated the Dilemma of Trade Liberalization and Government Revenues

Many economists believe that in the long run, the aggregate performance of open economies is better than that of closed ones, and that open policies contribute significantly to economic development. At the same time, many political scientists and policy makers fear that, in the short run, one of the steps towards openness — trade liberalization — may harm government revenues. However, in the 1990s, China successfully navigated the dilemma of trade liberalization and government revenues. In this period, China decreased tariff and non‐tariff barriers for WTO accession, but has achieved dramatically increased tariff revenues since 1999. This study explores how China implemented trade liberalization and simultaneously increased tariff revenues in the 1990s. It demonstrates that a series of institutional arrangements, including a reform of Criminal Law, rigorous anti‐smuggling activities and a de facto tax imposed on the export sector, successfully curbed smuggling activities through the processing trade, and made foreign‐invested manufacturing enterprises the major contributors to the stability of customs revenue. China's case shows that a prosperous, export‐oriented and foreign‐invested manufacturing sector could potentially provide a developing country with a source of customs revenue.     

Archaeometric Investigation of Medieval Pottery from Excavations at Novo Brdo,Serbia

Medieval pottery from excavations at Novo Brdo, Serbia, an important mining and trading centre during the 14th and 15th centuries, was investigated by a combination of optical microscopy, inductively coupled plasma – optical emission spectrometry, Fourier transform infrared, micro‐Raman and energy‐dispersive X‐ray fluorescence spectroscopy and X‐ray powder diffraction methods in order to determine its composition and firing temperature. The samples investigated were made of medium‐ to coarse‐grained, non‐calcareous clay, by a relatively well‐controlled firing procedure in an oxidizing atmosphere. The firing temperature was estimated to be 850–950°C. The similarity between the chemical composition of the investigated pottery and the local raw clay, combined with the outward appearance and the archaeological findings, indicate domestic production. The pottery is covered with the transparent lead‐rich glaze. Iron and copper were used as colourants.     

Landscapes of Time: Building Long-Term Perspectives in Animal Behavior*

In the 1960s, scientists fascinated by the behavior of free-living animals founded research projects that expanded into multi-generation investigations. This paper charts the history of three scientists’ projects to uncover the varied reasons for investing in a “long-term” perspective when studying animal behavior: Kenneth Armitage's study of marmots in the Rocky Mountains, Jeanne Altmann's analysis of baboons in Kenya, and Timothy Hugh Clutton-Brock's studies (among others) of red deer on the island of Rhum and meerkats in the Kalahari. The desire to study the behavior of the same group of animals over extended periods of time, I argue, came from different methodological traditions – population biology, primatology, and sociobiology – even as each saw themselves as contributing to the legacy of ethology. As scientists embraced and combined these approaches, a small number of long-running behavioral ecology projects like these grew from short pilot projects into decades-long centers of intellectual gravity within behavioral ecology as a discipline. By attending to time as well as place, we can see how this long-term perspective was crucial to their success; they measured evolutionary changes over generations of animals and their data provided insights into how the animals they studied were adapting (or not) to changing local and global environmental factors.     

Incentives for the Iranian Chemical Boom: A Strategic Motivation or Applied Needs?

Iran's scientific impact has suffered hard from decades of imposed and self‐elected isolation from Western influences and international collaboration. Lately, however, the world has witnessed a remarkable increase in scientific publications from Iranian scientists in fields like nanotechnology; material science; and, perhaps most pronounced, chemistry. In this article, the factors behind this “publication boom” are discussed and examined together with an analysis of the coherence between the country's long‐term research strategies and short‐term needs in relation to present organic chemical research conducted at various Iranian universities and institutes. Organic chemistry is a keystone in important Iranian industrial sectors like the petroleum and agricultural industries, and also in the growing field of life science and pharmacology. The development of the petroleum industry and further refinement of raw oil into value‐added fine chemicals holds a key position in the reinforcement of the Iranian economy and labor market, thus motivating a governmental investment in chemical science and research. Taking an approach to find a reasonable balance with the impact from Western and Far Eastern scientific communities, Iran's own scientific roots and Islamic ideology could well be the success factor in becoming a worthy player on the international scientific arena.     

“I spent the first year drinking tea”: Exploring Canadian university researchers’ perspectives on community‐based participatory research involving Indigenous peoples

Community‐based participatory research (CBPR) is generally understood as a process by which decision‐making power and ownership are shared between the researcher and the community involved, bi‐directional research capacity and co‐learning are promoted, and new knowledge is co‐created and disseminated in a manner that is mutually beneficial for those involved. Within the field of Canadian geography we are seeing emerging interest in using CBPR as a way of conducting meaningful and relevant research with Indigenous communities. However, individual interpretations of CBPR's tenets and the ways in which CBPR is operationalized are, in fact, highly variable. In this article we report the findings of an exploratory qualitative case study involving semi‐structured, open‐ended interviews with Canadian university‐based geographers and social scientists in related disciplines who engage in CBPR to explore the relationship between their conceptual understanding of CBPR and their applied research. Our findings reveal some of the tensions for university‐based researchers concerning CBPR in theory and practice.     

„On employera les meilleurs Graveurs pour les Figures”︁. Zeichner und Stecher der Berliner Akademie der Wissenschaften, 1700–1806

“We will employ the best engravers for the figures” – Draughtsmen and Engravers of the Berlin Academy of Sciences, 1700–1809. – Although barely mentioned in accounts of its history of the Berlin Academy of Sciences, draughtsmen and engravers were, from the very inception, essential collaborators. Based on previously overlooked archival sources, this paper investigates the strategies that scientists used to select the most appropriate candidates during the first hundred years of the academy's existence. These included: (1) the engaging of artists already known to the scientists or those who had been recommendaded to them; (2) maintaining long‐term relationships with a number of artists, and later with their offspring (who had frequently been trained by their fathers); in 1768 this strategy culminated in the creation of a permanent position for one academic draughtsman; and (3) hiring draughtsmen who specialised in the subject matter in question, which entailed, for example, employing different people to carry out anatomical and botanical illustrations.     

The technoscientists: a Swedish construction of basic research in World War II

The paper examines a group of engineers and scientists in Sweden in the 1930s and 1940s that worked to gain political support for what they called ‘technoscientific research’. Following their own terminology and the ideas of close relations between engineers, scientists, industries, and politics it implied, I call these actors ‘technoscientists’. Critical to their approach was the strategical use of the concept of ‘basic research’, constructed by the technoscientists to associate knowledge production with economic development and demarcate an area of responsibility for public support of industrial research. The technoscientists promoted this strategy by linking basic research to the technical exigencies caused by World War II and by integrating it with politics of welfare, defense, and trade. The technoscientists were thus important political reformers that laid the foundations of public support of science and technology before the 1950s and 1960s when science policy emerged as an institutionalized political practice in Sweden.     

Transdisciplinarity in Practice: The Emergence and Resolution of Dissonances in Collaborative Research on Brownfield Regeneration

Abstract

The restoration of areas contaminated by industrial or mining activities has been a major issue in environmental research in many European countries since the 1980s, and it also constitutes a major area of research at the Helmholtz Centre for Environmental Research — UFZ. Within this research environment, a consortium consisting of natural and social scientists has developed an EU-funded research project aimed at providing problem- oriented, tailored approaches and technologies for the revitalization of contaminated areas. The approach taken by the project is one that seeks to integrate scientific and non-scientific knowledge. In this paper we show how the idea of joint knowledge production between scientists and non-scientists is pursued in the context of the project. We explore how the rather fuzzy presentation of the transdisciplinary approach in the project proposal opens the door to interpretation and appropriation by scientists and practitioners alike. We describe a number of ad hoc solutions that were deployed to overcome specific dissonances during the collaborative production of knowledge (e.g. substituting common group learning for the single-handed elaboration of concepts by one project partner, or substituting the consultation of external experts for the mere gathering of information). Finally, we show how the interdisciplinary research environment at UFZ enhances the ability of the project team to resolve dissonances, improves collaboration between partners, and increases the innovative potential of project outputs.     

Geographers and the Discourse of an Earth Transformed: Influencing the Intellectual Weather or Changing the Intellectual Climate?

This article considers how geographers might choose to respond to many geoscientists' claims that we are entering ‘the age of humans’. These claims, expressed in the concepts of the Anthropocene, planetary boundaries and global tipping points, make epochal claims about Earth surface change that are also far‐reaching claims upon Earth's current inhabitants. The scale and scope of their normative implications are extraordinarily grand. After describing the content and wider context for these claims, the history of some geographers' engagement with global change research is sketched and their current contributions described. Wider alterations in the modus operandi of global change scientists seem to offer a perfect opportunity for geographers to demonstrate the intellectual and societal value of their discipline's ‘integrative’ aspirations. However, the article suggests that this opportunity is likely to be used in a rather conservative way that downplays the sort of wide, deep and plural forms of integrative analysis that a post‐Holocene world surely calls for. Such forms exist in geography but are currently not, by and large, feeding into wider debates in global change research about how to understand and influence the future of Earth and humanity. The question is: how might they serve to alter the intellectual climate prevailing in global change research as Future Earth becomes the new umbrella for its next phase of development?     

Arctic Explorer Robert E. Peary’s Other Quest: Money,Science, and the Year 1897

American Robert E. Peary is famous for his claim of being the first person to reach the North Pole. However, too little historical attention has been paid to independent parts of his long exploratory career. A closer examination of one year, 1897, in his two‐decade quest, reveals the substantial difficulties of being an explorer at the turn of the twentieth century. Peary used specially crafted arguments to endear himself to the recently organized but poorly connected professional scientists who proved to be his most earnest, if inconsistent, backers before 1898. Peary worked on the scientists’ behalf to locate, and sometimes create, publishing venues and stateside audiences for them, in exchange for their patronage. The money chase was difficult and time‐consuming, but did more than help the scientists and ensure Peary’s future backing. It introduced him to the young American scientific community, with whom he learned to “sell” the Arctic. Peary also used his scientific credentials to maintain a public image of the Arctic that allowed Americans to celebrate both the rugged hero and cultural superiority in this remote region.     

‘M GLOW BLUE’: ARCHAEOMETRIC RESEARCH AT MICHIGAN'S FORD NUCLEAR REACTOR

The Ford Nuclear Reactor operated from 1957 to 2003 on the University of Michigan's North Campus in Ann Arbor, Michigan. Over its 45‐year lifespan, the facility played a key role in archaeometric research, fostering early methodological studies using INAA and supporting archaeological materials science investigations of lithics, ceramics, metals and bone. One small part of the FNR's abundant legacy was the initiation of trace‐element studies of Oaxacan ceramics, which are now beginning to shed light on early exchange interactions and the origin of the Monte Albán state in the Valley of Oaxaca, Mexico, between 500 bce and 200 ce .     

Zur Pluralisierung im Luthertum des 17. Jahrhunderts und ihrer Bedeutung für die Deutungen von ‚Natur’︁

Building on methodological considerations in cultural history and historical anthropology, the following contribution proceeds from the concept of ?nature’? rather than from ?natural science’?, with the former understood here as the object of culturally determined projections, values and practices. This ?constructive’?, practice‐oriented concept of nature exposes perceptions of and attitudes towards nature that, owing to the usual reduction of nature to natural science, would otherwise have remained hidden, but which may well be essential to its constitution. To a certain extent, the term ?nature’? continues the terminological extension from ?natural science’? to ?natural philosophy’?, but as a heuristic device it more strongly implies the significance of culturally mediated practices and dynamics. The essay raises the following questions: Which religious conceptions entered into which attitudes towards nature and which religious expectations and interpretive matrices were the motivating forces behind which studies of nature? The figures within seventeenth‐century Lutheranism who shaped and promoted nature‐oriented attitudes and practices were not the ?orthodox’? scholars more strongly tied to academic and controversialist theology, but rather reform‐oriented theologians critical of the church. In the context of the inner differentiation and pluralization of seventeenth‐century Lutheranism, these reform‐oriented groups not only inspired innovate theological projects but also assumed a leading role, along with liked‐minded Christian laypersons, in interpreting and studying ?nature’?.     

Civic Science and Salmon Recovery Planning in Puget Sound

Today, science and scientists as experts no longer hold sway as unquestioned authoritative sources of objective information in many policy debates. This has led to growing frustration on the part of government officials and scientists over their inability to have science exert as meaningful a role as they think appropriate in the consideration and selection of policy alternatives. Given this development, what can be done to restore or otherwise ensure that the appropriate science and scientists are integrated into the policy process so that they matter to policy outcomes? There is general agreement that traditional top‐down, one‐way (from scientists to others), linear models for conceptualizing the role of science and scientists in the policy process are not capable of capturing the changed political, social, and “scientific” realities of the contemporary policymaking context. Many have gravitated to the concept of civic science/scientists as a new and improved model. Yet, despite clear progress in reconceptualizing the role of science in the policy process, there are gaps in the literature when it comes to actual applications of civic science. As McNie correctly notes: “it is essential that we develop a more robust understanding of experience and practical experiments regarding how relationships [and institutions] are constructed and managed across the science‐society boundary” (p. 29). This research develops lessons for civic science in the policy process by exploring an innovative collaborative governance effort by the National Oceanic and Atmospheric Administration Fisheries and the Shared Strategy for Salmon Recovery in Puget Sound (Washington). The integration of science into the salmon recovery process in this case relied on a series of actions that the Technical Recovery Team (TRT) took to bridge the traditionally separate science and policy spheres in order to increase the certainty of science impact, specific steps taken to establish and maintain the TRTs role as an authoritative, credible source of science, and the embrace of a results‐oriented, adaptive learning approach.     

NON‐DESTRUCTIVE ANALYTIC METHOD USING XRF FOR DETERMINATION OF PROVENANCE OF ARCHAEOLOGICAL OBSIDIANS FROM THE MEDITERRANEAN AREA: A COMPARISON WITH TRADITIONAL XRF METHODS*

A non‐destructive analytical method using wavelength‐dispersive X‐ray fluorescence (WDXRF) that allows the establishment of the provenance of archaeological obsidians was developed and a comparison with the classical XRF method on powders is discussed. Representative obsidian samples of all the geological outcrops of archaeological interest of the Mediterranean area (Lipari, Pantelleria, Sardinia, Palmarola and the Greek islands of Melos and Gyali), were analysed with the normal procedures used in rock analysis by XRF (crushing, powdering and pelletizing). The non‐destructive XRF analysis was instead conducted on splinters taken from the original geological pieces, with the shape deliberately worked to be similar to the refuse usually found at archaeological sites. Since the analysis was conducted on the raw geological fragment, intensity ratios of the suitably selected chemical elements were used, instead of their absolute concentrations, to avoid surface effects due to the irregular shape. The comparison between concentration ratios (obtained by traditional XRF methods) and the intensity ratios of the selected trace elements (obtained from the non‐destructive methodology) show that the different domains of the chemical composition, corresponding to the geological obsidians of the source areas, are perfectly equivalent. In the same way, together with the geological splinters, complete archaeological obsidians, from Neolithic sites, may be analysed and their provenance may be determined. The proposed non‐destructive method uses the XRF method. Due to its sensitivity, low cost and high speed, it is surely an extremely valid instrument for the attribution of the provenance of the archaeological obsidian from Neolithic sites.