A case of valgus ankle in an early Pleistocene hominin

Bipedal locomotion is a defining character of the hominin lineage. A skeletal correlate of bipedality is a perpendicularly oriented tibia relative to the plane of the ankle joint, positioning the foot directly under the centre of mass. Non‐human primates, in contrast, possess a tibial shaft that tilts laterally away from the plane of the ankle joint (valgus ankle), which positions the foot in inversion and is adaptive for arboreal climbing. KNM‐ER 2596 is a small distal tibia from 1.9 mya sediments at Koobi Fora, Kenya. Though it possesses some morphologies functionally linked to bipedality, such as an expanded metaphysis, it also possesses a valgus tilt to the ankle. We test the competing hypotheses that the KNM‐ER 2596 tibia is from a cercopithecoid, a non‐human hominoid, or a pathological hominin. A survey of the orthopaedic literature and a comparative study of modern human and non‐human primate tibiae support the hypothesis that KNM‐ER 2596 is from a hominin. In order to investigate the non‐phylogenetic causes of valgus ankle, we examined human skeletal tibiae with valgus tilt secondary to fracture of the distal fibula. Untreated breaks of the lower third portion of the fibula during childhood can result in a valgus tilt to the distal tibia and occasionally other peculiar morphologies found in the KNM‐ER 2596 tibia such as a superoinferiorly atrophied medial malleolus. The morphology of this tibia is incompatible with hypotheses that it is from a cercopithecoid or a hominoid, and instead, we suggest that KNM‐ER 2596 belonged to a hominin that may have suffered a fracture of the lower left fibula as a juvenile. Copyright © 2010 John Wiley & Sons, Ltd.     

The first archaeological case of Madelung's deformity?

An elderly male medieval skeleton excavated from St Gregory's Priory presented with unilateral Madelung's deformity. The right radius and ulna were shortened due to premature fusion of the distal growth plate. The radius displayed lateral and dorsal bowing and the ulna was dislocated posteriorly. Pronation and supination was not possible and the available hand bones presented with disuse atrophy. Degenerative changes had reduced the mobility of the elbow joint and marked cubitus valgus was demonstrated. The unilateral presentation, shortening of the ulna and atrophy of the hand bones and the sex of the skeleton suggest a post-traumatic rather than an idiopathic form of Madelung's deformity. As far as we are aware this is the first archaeological example of this condition.     

Inter-observer variation in coding osteoarthritis in human skeletal remains

Thirty-eight participants at the VIIIth European Meeting of the Paleopathology Association took part in a study of inter-observer variation in scoring osteoarthritis in human skeletal remains. Ten specimens representing different joints were used and five criteria of osteoarthritis were scored. Eleven of the 38 participants ranked themselves as beginners, 13 as experienced and six as very experienced; the data were subsequently examined using the results from these 30, comparing beginners with experts. Agreement as to whether or not changes were present on the specimens and on the degree of change was seldom complete but was greater when scoring eburnation and the presence of new bone on the joint surface than for the three other criteria. There was little difference between beginners and experts. Although all the specimens were chosen to meet our published criteria for osteoarthritis, the experts were unanimous is agreeing the diagnosis in only three cases and the beginners in only one. These results suggest that more work needs to be done to develop operational definitions for the classification of disease in palaeopathology and that great care must be taken when comparing disease frequencies between studies.     

Injuries to the skeleton due to prolonged activity in hand-to-hand combat

Two complete skeletons from the Hamman-Todd collection of the Cleveland Museum of Natural History (CMNH) show a suite of pathological lesions that suggest the individuals had been involved in boxing or other hand-to-hand combat. These lesions were studied and compared with medical and autopsy records. The aims of the research were to estimate the accumulated damage to the bones over time, to characterize the different types of the damage, and to establish criteria for hand-to-hand combat or violence for archaeological material. Our inspections showed that besides the muscle markings developed and the numerous healed fractures that are expected when someone is involved in such activities, other types of lesion are present that are helpful for a proper differential diagnosis. These are: degenerative changes at the lesser tuberosity of the humerus; focal necrotic changes/bone growth on the trochlea of the humerus; necrotic changes on the distal head of the ulna; bony patches on upper limb bones only; secondary centres of ossification failing to fuse (mainly in vertebrae and acromion); a huge conoid tubercle on the clavicle; bony spurs on the distal articular head of the metacarpals; necrotic changes on the femoral head next to the fovea and on the roof of the acetabulum; and a developed bony ridge for the attachment of the iliotrochanteric ligament. Finally, we propose a set of criteria that will help to identify people in archaeological material who were involved in hand-to-hand combat.     

Possible rheumatoid arthritis found in the human skeleton collected from the tomb of Joseon Dynasty,Korea, dating back to the 1700s AD

We report a possible rheumatoid arthritis (RA) case found in a Korean Joseon Dynasty (1392–1910) tomb encapsulated by a lime‐soil mixture barrier (LSMB). The tomb is thought to have been constructed during the 1700s AD (1760 AD by carbon dating). In our anthropological examination, joint destruction, erosion or fusion (signs of polyarthritis) were identified mainly in the peripheral skeleton. Especially in both sides of the wrist bones, severe destruction/joint fusion possibly caused by polyarthritis was observed. A similar polyarthritis pattern also was seen in the right foot bones, even though we failed to confirm this symmetry due to the missing left foot bones. Despite these findings, signs suggestive of polyarthritis are very rarely seen in axial bones, even though bony fusions are found in the atlanto‐occipital joint or thoracic vertebrae (TV) 9–10. By the osteological signs observed in this case, the individual, a female, might have been suffering from a very late stage of RA and died in her 40s, even though other forms of chronic arthritis could not be ruled out completely. Though the current case could not provide evidence to decisively settle the debates on the antiquity of RA, our report could be a stepping stone for forthcoming studies on RA cases found in East Asian countries. Copyright © 2009 John Wiley & Sons, Ltd.     

Thalassaemia: Its diagnosis and interpretation in past skeletal populations

The diagnosis of thalassaemia in archaeological populations has long been hindered by a lack of pathogonomic features, and the non‐specific nature of cribra orbitalia and porotic hyperostosis. In fact, clinical research has highlighted more specific diagnostic criteria for thalassaemia major and intermedia based on changes to the thorax (‘rib‐within‐a‐rib’ and costal osteomas). A recent re‐examination of 364 child skeletons from Romano‐British Poundbury Camp, Dorset revealed children with general ‘wasting’ of the bones and three children who demonstrated a variety of severe lesions (e.g. zygomatic bone and rib hypertrophy, porotic hyperostosis, rib lesions, osteopenia and pitted diaphyseal shafts) that are inconsistent with dietary deficiency alone, and more consistent with a diagnosis of genetic anaemia. Two of these children displayed rib lesions typical of those seen in modern cases of thalassaemia. The children of Poundbury Camp represent the first cases of genetic anaemia identified in a British archaeological population. As thalassaemia is a condition strongly linked to Mediterranean communities, the presence of this condition in a child from England, found within a mausoleum, suggests that they were born to wealthy immigrant parents living in this small Roman settlement in Dorset. This paper explores the diagnostic criteria for genetic anaemia in the archaeological literature and what its presence in ancient populations can contribute to our knowledge of past human migration. Copyright © 2010 John Wiley & Sons, Ltd.     

Tortuosity or aneurysm? The palaeopathology of some abnormalities of the vertebral artery

The anatomy of the vertebral artery (VA) and two pathological conditions which affect it—tortuosity and aneurysm—are described. The changes which these lesions produce in the cervical vertebrae are also described and we present two cases in which these changes have been found. One case is of a female aged at least 45 years at the time of death from a 15th century medieval cemetery site in Britain with what we consider to be tortuosity of the VA. The second case is of a male aged between 25 and 35 years at the time of death from a Coffin period site in Japan, dating to ca 1600 years BP. The changes in this skeleton are considered to be more in keeping with a diagnosis of aneurysm of the VA. Copyright © 2002 John Wiley & Sons, Ltd.     

Skeletal metastatic carcinoma: A case from 15th–20th century Coimbra,Portugal

This paper discusses the differential diagnosis of unusual and distinct pathological changes in the skeletal remains of a 40+‐year‐old female from 15th–20th century Coimbra (Portugal). The most affected area seems to have been the skull, but multiple lesions, lytic and/or blastic, have been found throughout the post‐cranial skeleton, more specifically in the scapulae, clavicles, humerus, sternum, ribs, sacrum, innominates and femurs. The differential diagnosis of the lesions gave rise to several possible pathological conditions, namely, Langerhans cell histiocytosis (granulomatosis or Histiocytosis X), multiple myeloma and metastatic carcinoma. Various macroscopic and radiological aspects lead us to consider metastatic carcinoma as the most probable diagnosis. Despite the argumentative identity of the possible primary lesion, age, sex and the mixed nature of the osseous response are consistent with cancer of the breast but do not exclude other carcinomas, namely lung cancer. With temporal and regional differences emerging in the frequency of malignant tumours, the identification of new cases becomes important, particularly from geographic areas where few cases have been reported. In fact, the present report adds to the only case of metastatic carcinoma detected in non‐identified Portuguese human skeletal remains until now. Copyright © 2009 John Wiley & Sons, Ltd.     

Bison Bone Fragmentation and Survivorship: a Comparative Method

Zooarchaeologists usually describe a bone fragment as a particular portion or segment using terminology based on skeletal orientation (e.g. proximal, anterior, lateral). A more precise understanding of bone fragmentation can be achieved by naming portions for discrete anatomical features and defined zones. Since the anatomical features are the diagnostic criteria for identifying and orienting bones, each specimen normally has at least one such portion, and a complete element contains all of them. This recording method facilitates study of the relationship between survivorship and volume density, and it enhances inter-site comparisons. The method employs the minimum number of elements (MNE) and minimum animal units (MAU) across a site-wide aggregate. Although illustrated here with an analysis of bison bones, the method can be adapted for the study of other taxa as well as for inter-species comparisons.     

Exploring Nonlinear Spatial Dependence in the Tails

In many instances it is of interest to measure the degree of similarity between neighboring regions. Spatial autocorrelation measures are the most popular means of doing it. However, such measures only capture a global linear relationship between regions, whereas in many circumstances a more general instrument is required. For instance, in economic poverty analysis or environmental applications (and in other cases where we are interested in extreme events and threshold exceedances) we should be more interested in the spatial pattern in the tails of the joint distributions. In this article we introduce some exploratory tool that focuses on the bivariate joint tails behavior to detect a pattern of spatial regularities. The method will be illustrated with reference to simulated environmental data.     

旅游口号设计框架构建及其偏离分析:基于衰减器作用视角

作为建立品牌认知、创建品牌资产和投射品牌形象的重要手段,旅游口号在"目的地竞争战"中发挥了重要作用。立足于"衰减器"作用机理,构建旅游口号设计规则框架。同时,根据旅游口号评价指标与设计规则的分歧倾向比例来定义偏离级次,实证分析不同地域尺度的旅游口号的偏离程度和偏离分布差异。研究结论显示：①衰减器的内部作用过程包括特征抽取和口号衰减两个阶段;②旅游口号的偏离情况具有地域尺度差异性。省域旅游口号的总偏离程度最高,景域旅游口号的偏离分布差异性最明显,而市域旅游口号和我国旅游口号的偏离分布一致。     

Cut Mark Cluster Geometry and Equifinality in Replicated Early Stone Age Butchery

Early Stone Age cut marks created during tool‐assisted carnivory potentially offer inferences into hominin butchery behaviour and access to complete or defleshed carcasses. Actualistic butchery trials of 16 goat and cow half‐carcasses were completed by an experienced butcher with replicated Oldowan tools to investigate how the geometric organisation of cut mark clusters reflects flake versus core tool use and bulk muscle versus scrap defleshing. A cluster of cut marks is defined as a series of adjacent cut mark striations that occur at an anatomical location and are bounded by unmarked cortical surface. Tool type and butchery action were predicted to differentially mark certain long bone portions and influence cluster attributes. Moulds of 613 cut mark clusters were photographed and measured using ImageJ software (National Institutes of Health, Bethesda, Maryland, USA) for cluster area, cut mark count, median cut mark length and standard deviation of cut mark length and angle. Analysis suggests the following results: (i) cluster attributes are correlated;(ii) changes in cluster geometry are related to increasing cut mark count and length but not tool type or defleshed muscle amount; (iii) large clusters occur on large animals; and (iv) long bone midshaft portions are cut‐marked during both bulk and scrap muscle defleshing. Analysis of 179 cut mark clusters on long bone shafts of sizes 1–4 mammals from three Okote member assemblages at Koobi Fora, Kenya, shows that archaeological clusters have a similar number of marks when compared with experimental clusters but are significantly smaller, have shorter median marks and include less deviation in mark length and angle. Archaeological clusters corroborate that increasing area is positively correlated with cut mark count, median mark length and standard deviation of mark length and angle. A quantitative inferential model that links cut mark cluster geometry to tool type or the amount of muscle defleshed is not supported by these data. Copyright © 2015 John Wiley & Sons, Ltd.     

Osteometric and molecular sexing of cattle metapodia

Sex identification of skeletal remains based on morphology is a common practice in Zooarchaeology. Knowledge of the sex distribution of slaughtered or hunted animals may help in the interpretation of e.g. hunting or breeding strategies. Here we investigate and evaluate several osteometric criteria used to assess sex of cattle (Bos taurus) metapodia using molecular sex identification as a control of the metric data. The bone assemblage used to assess these new criteria derives from the Eketorp ringfort in the southern parts of Öland Island in Sweden. One hundred metapodia were selected for molecular analysis of sex and we were able to genetically identify the sex of 76 of these elements. The combined results of the molecular and osteometric analyses confirm a significant size difference between females and males for several measurements for both metacarpals (Mc) and metatarsals (Mt). Our results show that some measurements are applicable for metapodials. These measurements include the slenderness indices such as the Mennerich’s index 1 and 3, as well as the distal breadth (Bd), the breadth between the articular crests (Bcr), and the maximum breadth of the lateral trochlea (BFdl). We show that they can be used for sexing of both metacarpals and metatarsals. The latter measurements offer an opportunity to study fragmented elements and thus a higher number of elements may be utilized for morphological sexing of archaeological bones. Size comparisons of Mc and Mt may also aid in the separation of bulls and oxen.     

Multiple myeloma in an early medieval skeleton

Detailed studies on neoplasms in prehistoric populations are rare. Each well-documented case can therefore add to our knowledge. In former times, palaeopathology could present only tentative diagnoses in the case of tumours. Today, modern diagnostic methods and a comparison with established cases make exact evaluations and their verification possible. During our study it became obvious that criteria for the diagnosis of recent tumours can be used as a guide. In this paper we present the most important findings of a malignant primary bone tumour (multiple myeloma) in an early medieval skeleton and its differential diagnoses. Even in the absence of histological findings, the remaining criteria (X-ray, age, localization, macroscopic features) permit the diagnosis of multiple myeloma to be made with some certainty.     

The pattern of spondylosis deformans in prehistoric samples from west‐central New Mexico

A Pre‐Columbian skeletal sample (n=42) from two ancestral Pueblo sites in the Rio Grande valley of west‐central New Mexico was examined for frequency and severity of spondylosis deformans (vertebral osteophytosis). No significant sex differences were detected. Degenerative changes in the collective sample are generally confined to no more than well‐defined horizontal lipping at the joint margins. Advanced proliferative osteophytic change is infrequent even in the oldest age category. Not surprisingly, the lumbar vertebrae were the most frequently and most severely involved vertebral segment for all three adult age cohorts defined. The cervical vertebrae were the least involved. This pattern generally conforms with observations made on other archaeological samples from west of the Mississippi River, but it contrasts with the general pattern of more extensive cervical involvement in Pre‐Columbian North American samples from the Eastern Woodlands. This possible east–west difference is hypothesized (Bridges, P.S. 1994. American Journal of Physical Anthropology 93: 83–93) to be related to differential burden bearing habits. Copyright © 2000 John Wiley & Sons, Ltd.     

Comment on the Analysis of Two Skeletons from Terqa,Syria

Recently, a report on two human skeletons from an Early Bronze Age tomb excavated at Tell Ashara, Syria has been published in International Journal of Osteoarchaeology. One individual was identified as a warrior following these criteria: (i) size and robustness of bones, (ii) cut marks on the humerus, (iii) reduction of the ulnar styloid process, both interpreted as healed weapon‐related trauma, (iv) well‐developed muscle insertions, and (v) degenerative joint disease. Actually, none of these five criteria support the conclusion because of the following reasons: (i) not necessarily all tall and robust men become warriors, (ii) the post mortem origin of cut marks on the humerus is more likely than sharp force trauma, (iii) there are several possible causes of the unusual ulnar styloid shape other than weapon‐related trauma, (iv) the interpretation of musculoskeletal stress markers and (v) degenerative joint disease lacked control for age, sex and body size. Copyright © 2012 John Wiley & Sons, Ltd.     

Observations on the undersurface of the skeletalized human acromion in two populations

In late life, the humeral impingement disorder becomes common due to degenerative changes in the rotator cuff which allow the proximal humerus to press against the acromion in elevation of the arm, so producing facets on the tip region of the subacromial surface and on the lateral margin of the greater tubercle of the humerus. To discover what changes occur prior to those described, 184 acromions below the age of 55 years were examined. During the 18–25 year period, the subacromial surface showed patterns of formation of surface trabeculae of new bone, some associated with union of the epiphysis or with remodelling as a response to the presence of the proximal humerus at a distance of 10–15 mm; others indicated a subacromial attachment of the coraco‐acromial ligament. As early as 30 years of age, flattening of the surface trabeculae of bone was noted in association with compression lipping of the outer margin of the greater tubercle of the humerus, the part that crosses closest to the subacromial surface during elevation of the arm. Although resembling changes found in the impingement disorder, in both populations by the age of 35 years the changes were too common to be so and were not associated with the erosive pitting of the upper surface of the tubercle regarded as the earliest bony criterion of degenerative change in the cuff. It is postulated that, in the normal shoulder joint, in raising the arm, pressure is exerted, perhaps transiently, in the subacromial bursa and adjacent soft tissues which induces the compressive changes described. Probably due to the physically arduous lifestyle of the islanders, these changes occurred earlier among them; so did (but later) cuff degeneration indicated by erosion of the humeral tubercle. Copyright © 1999 John Wiley & Sons, Ltd.     

Morphological Characteristics of Healthy and Osteoarthritic Joint Surfaces in Archaeological Skeletons

Osteoarthritis is a major health concern in living populations, as well as being one of the most common pathological lesions identified in the archaeological record. The aetiology of the disease remains unclear, with a multi‐factorial influence of physical strain, age, genetics, and obesity. Previous studies have identified a relationship between the presence of knee osteoarthritis on the distal femoral joint and the morphology of the intercondylar notch, patellar groove, and medial condyle. The current study expands this research to investigate the relationship between distal femoral, distal humeral, and proximal ulnar joint morphology and osteoarthritis with 3D shape analysis techniques. These methods provide a more detailed analysis of joint morphology in order to determine any relationship between 3D shape and osteoarthritis. The results indicate a complex relationship between joint shape and knee osteoarthritis, with eburnated right femora showing a statistically significant association. The shapes associated with eburnated or affected femoral joints can be explained by osteophyte development, and therefore likely represent systematic shape changes and not a particular joint shape predisposing individuals to the condition. There was no identifiable relationship found in the proximal ulna or distal humerus, indicating that joint shape is unlikely to influence the development of the condition in the elbow joint and that any shape changes produced by osteoarthritis are not systematic or quantifiable. The joints analysed in this study were highly influenced by asymmetry, sexual dimorphism, and allometry, resulting in a small sample size of affected joints in many datasets. Further analyses of large skeletal samples are needed to more thoroughly investigate the possible relationship of distal femoral joint shape and osteoarthritis. Copyright © 2013 John Wiley & Sons, Ltd.     

Identification of urate crystals in gouty individuals

In paleopathology cases of gout have traditionally been identified using the character of erosive bony lesions, but in clinical medicine identification of monosodium urate crystals in joint fluid plays a central role in diagnosis. Work undertaken on three skeletal individuals who had been buried, demonstrates that crystals can be identified using polarising microscopy. The crystals were identified as monosodium urate. Results from this study appear to demonstrate that identification of monosodium urate crystals could be used to assist in the diagnosis of gout in paleopathology. Further work is required to establish the full range of spatial and temporal contexts from which such crystals might be found.