Multi-level Science Policy and Regional Innovation: The Case of the Munich Cluster for Pharmaceutical Biotechnology

Knowledge-based industries tend to develop within regional or local clusters that allow for knowledge spillovers, the generation of a critical mass of complementary competencies and skills as for spatial proximity to academic organizations out of which many highly innovative firms have been founded. The prototype of that development certainly is the biotechnology industry which has emerged since the 1970s first in the US where especially small and medium-sized research companies have been established around leading science bases. Following the example of the US biotechnology industry, public policies in many industrialized countries aimed at stimulating cluster formation in biotechnology. This holds true especially for member states of the European Union (EU) where public policy initiatives have been initiated at different territorial levels. This article refers to the Munich pharmaceutical biotechnology cluster and applies institutional and organizational indicators that have been developed in various systemic analyses of technological development and innovation. It will be shown that reforms of the institutional environment in which the innovative organizations are embedded were crucial for the commercialization of biotechnological research in Germany. These reforms have occurred mostly at the regional and national level, whereas the EU played a role especially in establishing the regulatory framework for the biotechnology industry. Organizational indicators will be applied in order to assess the modes of knowledge production within the cluster.     

Are there differences in social capital related to corporate regional engagement in dynamic and less dynamic non-core regions?

ABSTRACT

This article explores corporate regional engagement and related social capital in non-core regions. Corporate regional engagement comprises various activities of firms to influence regional contexts, which are challenging in non-core regions (e.g. on account of their organizational or institutional thinness). Corporate regional engagement engenders positive effects for regional development when firms collaborate among themselves (bonding social capital) and with other actors (bridging social capital) to improve regional endowments. We assume that dynamic regions have at their disposal higher levels of inclusive social capital in terms of collaboration networks for regional concerns and trust, while less dynamic regions have more exclusive and fragmented social capital. Consequently, less dynamic regions in particular appear to have potential to develop in a more social sense by activating the endogenous potential of region-wide collaboration. Those assumptions are tested based on a survey with Chief Executive Officers from the manufacturing industry from three dynamic and three less dynamic Swiss regions. The findings show that in dynamic regions, more firms are members of regional cross-industry associations, favouring regional collaboration; in less dynamic regions, meanwhile, more firms are members of industry-specific associations and service clubs, where benefits seem to be higher for individual firms than for the regional business environment.     

University–Industry Knowledge Transfer and Network Patterns in Romania: Does Knowledge Supply Fit SMEs' Regional Profiles?

Universities' potential to contribute to regional value creation has been extensively discussed so far and significant literature has been devoted to celebrated cases in highly industrialized and developed countries. Assuming that it would be misleading to generalize from “exceptional” cases, some authors have focused their attention specifically on the influence of universities in less developed areas regions and countries, where university–industry relations are far from being a Triple Helix. This paper focuses on the mechanisms of university–industry knowledge transfer (KT) in Romania, a post-communist country with relatively weak regional innovation performances, except for the capital region Bucharest-Ilfov. The purpose of the study is to construct an index to compare university–industry KT across the eight Romanian regions. Data to be aggregated are collected from 90 Romanian higher education institutions and refer to their KT potential in terms of human, financial and relational inputs, outputs and outcomes (patent applications, new products and services, spin-offs and commercial income). Finally, universities' regional KT performances are compared to small and medium enterprises territorial patterns and issuing policy implications are discussed.     

Different Modes of Innovation and the Challenge of Connecting Universities and Industry: Case Studies of Two Regional Industries in Norway

The paper argues that no single formula exists for how universities can stimulate innovation activity and industrial development in a particular region. The type of university–industry cooperation must be fined-tuned according to the knowledge base of the university and to the dominant mode of innovation in the regional industry. This article discusses two different modes of innovation: science, technology, innovation (STI) and doing, using, interacting (DUI). The unit of analysis is innovation and cooperation with universities in two regional industries in Norway, which are dominated by the two modes of innovation: STI (marine biotechnology in Tromsø) and DUI (oil and gas equipment suppliers in Agder). The empirical analyses demonstrate the different roles that universities play in these two regional industries. The University of Tromsø is the main organization behind the development of the marine biotechnology industry in Tromsø and is an important knowledge node and source of biotechnology spin-offs. Equipment suppliers in Agder have become world leaders in some niches, almost without research cooperation with universities. A general lesson is that the dominant mode of innovation in a regional industry makes a difference to the role universities can play in stimulating the development of the industry.     

Persistence and Change of Regional Industrial Activities: The Impact of Diversification in the German Machine Tool Industry

The paper investigates the stability and change of regional economic activities in the long run. As the unit of analysis, we selected the machine tool industry in West Germany for the years 1953–2002. We spot a strong variance in the activities between different regions. These differences are relatively stable over time, and the regional activities are rather path-dependent. Nevertheless, the paper also identifies changes in the level of activities. As the main driving factors for these developments, we examine the effect of changing regional degrees of diversification over time. We find that those regions which generally broaden their scope of activities have a higher likelihood to grow than regions which are specializing. Furthermore, diversification into totally new technological and product fields is only beneficial under specific circumstances based on technological and market developments. Hence, in most cases, a broad diversification is superior to one focusing on new state-of-the-art technological fields.     

The changing system of European cities and regions

This paper analyses the current structure of the system of European cities and regions, relations within the system and how it is changing. Cluster analysis distinguished eight regional types: metropolitan, semi‐peripheral and peripheral service regions; central, semi‐peripheral, peripheral and collapsed industrial regions; and agricultural regions. The core of European industrial societies proves to be almost identical with the city belt that dominated economic development in pre‐industrial Europe. Two possible paths of change are discussed: delocalization of simpler, labour cost‐intensive activities towards the periphery (delocalization hypothesis), or structural changes in industrial core regions and persisting marginal status in the periphery (restructuring hypothesis). Neither hypothesis could be confirmed or rejected unequivocally: there were indicators for the continuing importance of urban service centres but no peripheral industrialization for the continuing dominance of industrial core regions while undergoing structural changes. It is concluded that there are hardly any signs of convergence between core and peripheral regions.     

Regional skill relatedness: towards a new measure of regional related diversification

ABSTRACT

This paper proposes a novel index of regional skill-relatedness and calculates this measure for all Norwegian labour-market regions. Studies of regional related diversification rely on measures of related variety, which build on the industry classification hierarchy. However, the growing literature identifying similarities in knowledge and competences across industries demonstrates that these classifications fail to identify a great deal of actual skill relatedness, and that measures based on empirical measures of industry relatedness are required. The skill relatedness measure builds on labour mobility flows across industries to develop a relatedness matrix for Norwegian industries. It further uses social network analysis to identify the number of other regional industries to which each industry in a particular region is related. Comparing this measure to the related variety index, the analysis shows that the two measures are highly correlated, but that the regional skill relatedness index is able to identify more of the relatedness across industries. In particular, the related variety index tends to underestimate the level of relatedness in many of Norway’s most technologically sophisticated manufacturing regions, whereas these rank highly in the regional skill relatedness index. Consequently, the regional skill relatedness index represents a promising new tool for identifying relatedness in regional systems.     

The Role of Location and Regional Networks for Biotechnology Firms in Israel

This article presents results of a study of the Israeli biotechnology sector. The findings of the study show that despite the small geographical size of the country, the Israeli biotechnology industry tends to a great extent to cluster around leading research institutes. Based on a survey of 109 high-tech projects, the study suggests that the relatively weak business background of the entrepreneurs, the fact that most of them have worked at research institutes and that most new biotechnology firms were originated from ideas that came out of universities or research institutes, can provide possible explanations for this geographical concentration. The research emphasizes the relative importance biotechnology entrepreneurs ascribe to networking, both in very early stages as well as in advanced stages of the firm development process. It is argued that although the focus of the network changes over time, both geographically and in content, its links to local research partners are maintained. It is suggested that earmarked regional support policies are crucial to the development of networks required by new biotechnology firms.     

区域经济增长的文化产业驱动效应研究——基于省级面板数据的分析

本文采用中国31个省份1996-2013年的面板数据,对中国文化产业与经济发展的内在驱动效应展开研究。研究发现:第一,文化产业投入和产出规模扩张对地区GDP和人均GDP增长具有显著作用,两者间的交互效应会加大其对经济发展的推动力;第二,文化产业有助于带动旅游业和整个第三产业发展,促进地区经济增长;第三,中国文化产业对经济发展的带动效应存在显著的地区差异,西部地区文化产业对经济发展的提升作用最大,中部和东部地区效应相对不足。因此,进一步加大对文化产业发展的政策支持,实现文化产业的合理布局,不仅能够促进整体经济增长,而且可以实现区域平衡发展。     

Renewable Energy Innovation and Governance in Wales: A Regional Innovation System Approach

This paper draws on research commissioned to investigate the regional innovation system of Wales on green innovation, focusing on the renewable energy sub-sectors of wind, solar and biomass. It shows how many innovative firms operate within regional networks, cooperating and interacting not only with other firms such as suppliers, customers and competitors, but also with research and technology resource organizations, innovation support agencies, venture capital funds, and local and regional government bodies. The paper argues that within the region there is the presence of various renewable energy production platforms, usually based on core technologies (wind, solar, biomass, marine, etc.) at different levels of development. They involve a mix of established energy utilities and new sustainable energy businesses that are positioned at different levels within the renewable energy supply chain. The research shows that the regional government is playing an important role in supporting the renewable energy industry; nevertheless, more needs to be done to facilitate planning control, provide skills and create new demands for renewable energy that will further foster business growth and further strengthen the existing manufacturing base and innovation in Wales. The paper identifies some weaknesses in the Welsh energy innovation system, not least that energy is not a devolved responsibility and it argues that there is some scope for the Welsh Assembly Government to further investigate gaps within the green innovation supply chain and act on strengthening regional capabilities within the industry but also to support and investigate further opportunities for inward investment.     

Agglomeration,foreign firms and firm exit in regions under transition: the increasing importance of related variety in Hungary

ABSTRACT

Related variety of economic activities is widely recognized to induce regional development; however, it is not clear how this mechanism takes place in regions that go through major structural and institutional transformation. Furthermore, foreign direct investment (FDI) is typically a major source of structural change in these areas; and we still need a better understanding on how foreign-owned (foreign) firms affect the dynamics of domestic-owned (domestic) companies. For these reasons we analyse firm-level exit in Hungarian city regions between 1996 and 2011, over the late post-socialist transition in manufacturing industries, focusing on the difference between foreign and domestic firms. Introducing ownership into the related variety calculation, we estimate the probability of firm exit with the region-level related variety calculated separately for foreign and domestic firms. Our results suggest that related variety of foreign firms decreases the probability of domestic firm exit earlier during the economic transition compared to the related variety of domestic firms. This finding supports the idea that FDI plays a formative role in regions under transition, and shows that domestic firms benefit from being in agglomerations where foreign firms are technologically related to each other.     

NRM Regions in Australia: the ‘Haves’ and the ‘Have Nots’

This paper identifies external factors affecting the capacity of Australia's now‐formalised 56 regional natural resource management (NRM) bodies and their community‐based Boards to meet planning and management responsibilities. It demonstrates that little is known about the basic capacity‐related characteristics of NRM regions, despite the lengthy and elaborate process of regionalism that Australia has embarked upon, with its associated and substantial devolution of responsibilities and resources. A suite of indicators is used to develop an ‘exploratory’ capacity typology of NRM regions. The ten regional ‘types’ identified are found to attract varying budget allocations under the Natural Heritage Trust Extension and National Action Plan for Salinity and Water Quality. There are indications that State and regional interests within and outside NRM can significantly influence the distribution of resources. An examination of resources allocated to capacity‐building activities shows significant differences between regions in the scale of resources allocated (0–96% of total budget). The paper argues the case for intervention to reduce the gap between ‘have’ and ‘have not’ regions, and for further exploration of disparities in the allocation of resources to capacity‐building activities. Clarification is needed of the extent to which capacity‐building activities adequately target regional NRM bodies and their Boards.     

美国大都市区尺度上的工业区位研究

工业化和城市化之间的互动关系体现在都市区尺度上的工业区位上。本文在新经济地理学和城市地理学所揭示的产品差异化和城市集聚效应相互关系的基础上,通过区位熵分析、赫芬达尔-赫希曼指数,对美国工业区位与大都市区间的耦合关系进行实证研究。结果显示:集聚于大都市区核心区的往往是产品个性化和定制化程度较高的行业;位于大都市区外围区的大都是产品依赖于城市市场,但标准化程度较高的行业;传统制造业则往往位于非大都市区。多数都市工业的市场集中度较低,而大部分传统工业的市场集中度较高。这不仅印证了新经济地理学的理论推演和城市地理学的行业分析,而且对包括中国在内的转型国家城市及其产业发展具有重要的参考意义。     

Wage Effects of Unemployment Duration and Frequency

This paper analyzes the wage effects of unemployment duration and frequency for different regional labor market situations in The Netherlands using a simultaneous equations approach. The main finding is that unemployment duration has a significant negative effect and the frequency of unemployment a significant positive effect on wages in the core regions with relatively low unemployment rates. In the periphery with relatively high unemployment rates no significant effects of unemployment duration and frequency are found. It is argued that in the core regions unemployment duration is primarily viewed as a personal indicator of low productivity whereas in the periphery it is attributed to the situation in the regional labor market.     

An Economic Regionalization of North Vietnam

A North Vietnamese graduate student at Moscow University offers a division of North Vietnam into four economic regions and assesses their future development in terms of energy-and-production cycles (groups of technologically interrelated activities proposed by N. N. Kolosovskiy). In a second paper, the author conceptualizes economic regions as consisting of a core or center, accounting for most of the production; an inner shell dependent on the core, and an outer shell that may gravitate to any of a number of adjoining core areas depending on the purpose of the study. The original boundaries of the four-region system of North Vietnam are reviewed in light of the “outer shell” concept. The four-region system is essentially confirmed, but the allocation of some provinces in the “outer shell” is found to be disputable, and regional boundaries have been adjusted.     

Knowledge-Intensive Business Services as Knowledge Intermediaries in Industrial Regions: A Comparison of the Hsinchu and Tainan Metropolitan Areas

Abstract

The literature repeatedly stresses the role of knowledge-intensive business services (KIBS) as a provider of knowledge and information to other businesses and organizations. KIBS simultaneously promotes, mediates and enables client innovation. This investigation mainly seeks to link KIBS to the analytical structure of concepts, including regional innovation systems, knowledge exchanges and innovation patterns. This investigation interprets the role of KIBS as that of a knowledge intermediary that mediates and transmits knowledge among actors. This study also clarifies the mechanism of knowledge exchanges in different geographic innovation systems. The analytical results obtained by this investigation are applied to analyse the intermediary functions of KIBS in various metropolitan areas in southern and northern Taiwan. This investigation demonstrates variations in how KIBS act as knowledge intermediaries, and that these variations depend mostly on industrial cluster patterns, the dominant innovation patterns at their locations and the birth of sustainable KIBS. KIBS in large/core metropolitan regions, thus, are initially based on science, technology and innovation industrial activities, and further closely resemble doing, using and interaction industrial activities. Consequently, more informal learning processes, such as local buzz and discussion/competition relations, tend to develop in such regions.     

Mapping the Geography of R&D: What Can We Learn for Regional Innovation Policy in the Czech Republic and Beyond?

Administrative regions do not necessarily correspond to areas that are homogenous in terms of innovation intensity. Although this has been recognized in the literature, quantitative evidence that explicitly considers this problem is rare. Using spatial exploratory analysis on detailed regional data derived from a census of R&D performers in the Czech Republic, we identify local spatial clusters of R&D activities and assess the extent of their (mis)match with administrative borders. Overall, the results support the arguments for regionalization of innovation policy. However, the existing policy units do not appear well suited for this purpose. On one hand, there is a need for policy coordination between multiple administrative regions. On the other hand, however, there are diverse patterns within them. Similar problems are likely to haunt the regionalization process in many other countries, which is alarming, as the regional accent of innovation policies becomes ever more vehement over time.     

Regional embeddedness,relatedness and inter-regional linkages among less developed regions in Central Europe

This paper aims at a comprehension of existing intra-/inter-regional production flows in a dynamically transforming, export-oriented economy in Central Europe. Drawing on evolutionary economic geography combined with input–output approaches, we have assessed the sectoral compositions and relationships between regions from a buyer-supplier interactions perspective. Inspired by contemporary literature we applied concepts of regional embeddedness, relatedness and vertically related variety. Conceptually we argue that the degree of embeddedness of regions is differentiated and spatially non-random. The differences will depend to a large extent on the economic characteristics and on the ability of key actors and institutions in these regions to respond actively to changing opportunities and threats. Empirically we have found: that economically more developed regions are relatively more embedded in terms of production flows and have greater sectoral variety, whereas regions with high export-dependence are economically backward, and have higher concentration of industry and negative associations with innovation activity and overall innovation potential. The intensity of interregional production flows increases as the regional economies vary more from each other, but beyond a certain level of structural difference the rate of mutual flows decreases; and that the intensity of interregional relations depends on the relatedness of the economic bases.     

东北地区经济空间极化及其驱动因子的定量研究

在对区域经济空间极化相关文献研究综述的基础上,借鉴有关研究方法,遵循从过程到格局、机理,从整体到局部的研究思路,首先以人均GDP为测度指标,综合分析东北三省及其内部各区域经济差异与空间极化的过程与空间格局,接着以人均GDP的极化水平为应变量,以工业总产值、当年实际直接利用外资额、社会商品零售总额、全社会固定资产投资、全员劳动生产率和复合流量的极化水平为自变量,建立多元线性回归模型,分析区域经济空间极化的内在机理。结果表明:①区域经济发展存在空间极化现象,且整体呈现出南强北弱的态势;②哈长经济区和辽中南经济区已初步形成,其中哈长经济区处于明显的集聚阶段,而辽中南经济区扩散效应已开始发挥作用;③地区经济发展的位序排名及其变化表明区域经济发展中心逐步南移;④区域差异和空间极化总体变化趋势基本一致,呈现出先升后降,但总体水平呈上升的变化态势;⑤多元线性回归模型表明各动力因子的作用程度和作用趋势不尽相同,但工业总产值和全员劳动生产率是东北三省及其内部区域经济空间极化演变所共有的主导驱动因子,说明其区域经济发展是一个内生增长过程,并提出应强化市场体制转轨、国有企业改组改革、产业结构升级换代和政府政策的导向作用。     

省域旅游竞争力的空间格局与形成机理研究

本文在系统梳理旅游目的地竞争力研究主要成果的基础上,通过搭建省域旅游竞争力评价指标体系,运用多指标综合评价的主成分分析法,以省域为研究单元,对我国31个省市自治区的旅游竞争力水平进行定量评价。结果显示：规模实效因子、企业活力因子、经营绩效因子和消费支撑因子是影响我国省域旅游竞争力总体水平的主要因子,4项指标对我国省域旅游竞争力的累积贡献值已经超过80％;从空间结构上看,我国各省市自治区之间旅游竞争力总体水平之间存在较大差距,东中西部地区各省份的旅游竞争力之间存在显著的梯度递减格局,东部地区省份的旅游竞争力水平领先于中西部地区,但一些省份也表现出一定的变异特征。从旅游的综合性和系统性角度出发,研究认为区域旅游竞争力的提高是一项系统工程,区域旅游产业的效益更多地来自于全方位和全要素的产业发展,而这些要素既涵盖旅游系统内部的各项要素,又与区域社会经济发展的整体水平密切相关,因此,增强区域旅游竞争力必须强调各项要素的均衡、协调发展。