Animal electricity at the end of the eighteenth century: the many facets of a great scientific controversy

In the 1790s, Luigi Galvani and Alessandro Volta were the main protagonists of a lively debate on the role of electricity in animal organisms. Significant developments originated from this debate, leading to the foundation of two new disciplines, electrodynamics and electrophysiology, that were to play a crucial role in the scientific and technological progress of the last two centuries. The Galvani-Volta controversy has been repeatedly reconstructed, sometimes in an attempt to identify the merits and the errors of one or the other of the two protagonists, sometimes with the aim of demonstrating that the theories elaborated by the two Italian scholars were irreconcilable, reflecting completely different ways of looking at phenomena and conceiving of scientific research. In this article a different interpretation is offered, based on a discussion of the scientific issues that were central to Galvani's and Volta's research, and with reference to the context of science and society of the eighteenth century.     

Alexander von Humboldt: Galvanism,Animal Electricity,and Self-Experimentation Part 2: The Electric Eel,Animal Electricity,and Later Years

After extensive experimentation during the 1790s, Alexander von Humboldt remained skeptical about “animal electricity” (and metallic electricity), writing instead about an ill-defined galvanic force. With his worldview and wishing to learn more, he studied electric eels in South America just as the new century began, again using his body as a scientific instrument in many of his experiments. As had been the case in the past and for many of the same reasons, some of his findings with the electric eel (and soon after, Italian torpedoes) seemed to argue against biological electricity. But he no longer used galvanic terminology when describing his electric fish experiments. The fact that he now wrote about animal electricity rather than a different “galvanic” force owed much to Alessandro Volta, who had come forth with his “pile” (battery) for multipling the physical and perceptable effects of otherwise weak electricity in 1800, while Humboldt was deep in South America. Humboldt probably read about and saw voltaic batteries in the United States in 1804, but the time he spent with Volta in 1805 was probably more significant in his conversion from a galvanic to an electrical framework for understanding nerve and muscle physiology. Although he did not continue his animal electricity research program after this time, Humboldt retained his worldview of a unified nature and continued to believe in intrinsic animal electricity. He also served as a patron to some of the most important figures in the new field of electrophysiology (e.g., Hermann Helmholtz and Emil du Bois-Reymond), helping to take the research that he had participated in to the next level.     

Animal Electricity at the End of the Eighteenth Century: The Many Facets of a Great Scientific Controversy

In the 1790s, Luigi Galvani and Alessandro Volta were the main protagonists of a lively debate on the role of electricity in animal organisms. Significant developments originated from this debate, leading to the foundation of two new disciplines, electrodynamics and electrophysiology, that were to play a crucial role in the scientific and technological progress of the last two centuries. The Galvani-Volta controversy has been repeatedly reconstructed, sometimes in an attempt to identify the merits and the errors of one or the other of the two protagonists, sometimes with the aim of demonstrating that the theories elaborated by the two Italian scholars were irreconcilable, reflecting completely different ways of looking at phenomena and conceiving of scientific research. In this article a different interpretation is offered, based on a discussion of the scientific issues that were central to Galvani's and Volta's research, and with reference to the context of science and society of the eighteenth century.     

The Role of The Gentleman's Magazine in the Dissemination of Knowledge About Electric Fish in the Eighteenth Century

Although torpedoes and Malopterurus, a Nile catfish, had been described and even used medically in antiquity, their discharges were poorly understood before the second half of the eighteenth century. It was then that their actions, along with those of certain South American “eels,” became firmly associated with electricity. The realization that an animal could produce electricity marked a turning point in the history of neurophysiology, which had long described nerve actions with recourse to animal spirits. By examining The Gentleman's Magazine during the period when electric fish were becoming electrical, one can begin to appreciate how new discoveries about these unusual creatures captured the imagination of scientists and were filtered down to the literate public.     

Guidelines for Authors

Though known primarily for his work on muscle energetics, Archibald Vivian Hill, as discussed below, also made important scientific and pedagogic contributions to nerve physiology.     

The 1932 and 1944 Nobel Prizes in physiology or medicine: rewards for ground-breaking studies in neurophysiology

In 1932 Sherrington and Adrian were awarded the Nobel Prize in Physiology or Medicine "for their discoveries regarding the functions of neurons" and in 1944 Erlanger and Gasser were awarded the same prize "for their discoveries relating to the highly differentiated functions of single nerve fibres." Sherrington made important discoveries on the reflex functions of the spinal cord, formulated the concept of the "synapse," defined the principle of the "final common path," studied "reciprocal innervation" and showed that central inhibition was an active phenomenon. He distinguished three types of receptors: extero-, intero-, and proprioceptive, studied the proprioceptive reflexes in the decerebrate animal and mapped their pathways in the spinal cord. Adrian made fundamental discoveries on the function of single nerve fibers, developed new techniques for the amplification of the weak signals and discovered that increased stimulation resulted in increased frequency of the impulses, the amplitude being unaffected. Erlanger and Gasser introduced the cathode-ray oscillograph and demonstrated the existence of three main groups of nerve fibers, A, B, and C, the conduction velocities of which were in approximately linear relationship with the fiber diameter, the A-fibers being the fastest and thickest and the C-fibers the slowest and having the finest diameter. Together the contributions by the four Laureates paved the way to modern neurophysiology.     

进化之调律:斯宾塞与清末的种群竞争论述

斯宾塞学说构成清末种群进化和竞争论述的主要外在资源。斯宾塞以进化的哲学思维来缀合威廉·卡彭特、查尔斯·赖尔所代表的动物生理学和生物历史知识,回应马尔萨斯的人口论。19世纪50年代以来在中国译介和流行的正是卡彭特所代表的生理学著述片段或与其相似的种群差别认知。知识界对斯宾塞的翻译,意味着中国在戊戌时期发生了类似的理论缀合过程。清末知识人以种分贵贱、黄白同为贵种调整了斯宾塞的种群进化位阶表述,抵制欧洲人歧视东亚黄种之心。同时,他们却强化了贵贱种之间的等级关系,营造"退化""灭种"的焦虑意识和压迫感,警告需积极参与生存竞争来提升种群的心智和自律性,从而为政治变革酝酿社会气氛。     

Urbanization,Place of Experiment And How the Electric Fish Was Caught by Emil Du Bois-Reymond

Laboratories, along with the researchers, organisms, instruments, and experiments associated with these places of investigation, are not isolated from the world beyond their physical and institutional boundaries. Both laboratories and the cities in which they are embedded are subject to change, as was most dramatically apparent in their dynamic and far-reaching transformation during the industrial revolution of the nineteenth century. Using the example of Berlin and the institutionalization of experimental physiology by Emil du Bois-Reymond, in this paper I study experimental work on frogs and fish in order to demonstrate how a city and a laboratory cooperate in the production of knowledge. Emil du Bois-Reymond's research on electric fish illustrates how an exotic organism and a laboratory came together in a city and how the research was driven by innovation and development in urban and industrial technology. Ongoing changes in the urban landscape entered du Bois-Reymond's workplace and became part of the material culture of his experimental physiology and his attempts to demonstrate that the electric fish discharge is fundamentally similar to the excitation of nerve and muscle.     

Urbanization, place of experiment and how the electric fish was caught by Emil du Bois-Reymond

Laboratories, along with the researchers, organisms, instruments, and experiments associated with these places of investigation, are not isolated from the world beyond their physical and institutional boundaries. Both laboratories and the cities in which they are embedded are subject to change, as was most dramatically apparent in their dynamic and far-reaching transformation during the industrial revolution of the nineteenth century. Using the example of Berlin and the institutionalization of experimental physiology by Emil du Bois-Reymond, in this paper I study experimental work on frogs and fish in order to demonstrate how a city and a laboratory cooperate in the production of knowledge. Emil du Bois-Reymond's research on electric fish illustrates how an exotic organism and a laboratory came together in a city and how the research was driven by innovation and development in urban and industrial technology. Ongoing changes in the urban landscape entered du Bois-Reymond's workplace and became part of the material culture of his experimental physiology and his attempts to demonstrate that the electric fish discharge is fundamentally similar to the excitation of nerve and muscle.     

I.M. Sechenov (1829 - 1905) and the scientific self-understanding for medical sciences

There is no discussion about the historic relevance of I. Sechenov for physiology and neurosciences as the "father of Russian modern physiology". But he is relevant for modern natural science too because of his basic epistemological and ontological work. He did not accept the up to now basic paradigm of "Ignorabimus" which can be seen as the reason to exclude even the generalizable aspects of individuality, creativity and spontaneity from natural science. He developed techniques for empirical based science to deal with materialistic and idealistic aspects of the comprehensive person the "ignoramus" according to the actual stay of knowledge and the acceptable ontologies. He demonstrated that ontologies ("paradigms") can be used as tools according to the given problem which should be solved. So Sechenov can be seen as a precursor of the so efficient philosophical positions of Einstein and Th. Kuhn. The stay of the art in physiology and neurosciences changed since the time of Sechenov dramatically. Therefore the philosophical positions of the 19th century should be discussed. Maybe this is indispensable for the needed linkage between materialistic and idealistic aspects of a person. For this the proposals of Sechenov are helpful up to now but nearly unknown. There is no discussion about the historic relevance of I. Sechenov as the "father of Russian physiology." But he is relevant for modern natural science too because of his epistemological and ontological work. He did not accept the up to now basic paradigm of "Ignorabimus" that can be seen as the reason to exclude even the generalizable aspects of individuality, creativity, and spontaneity from natural science. He demonstrated that ontologies ("paradigms") and epistemology can be used as tools according to the given problem. So Sechenov can be seen as a precursor of the so efficient philosophical positions of Einstein and Th. Kuhn. The state of the art changed dramatically. Therefore, the philosophical positions of the nineteenth century should be questioned. Maybe this is indispensable for the needed link between materialistic and idealistic aspects of a person as a whole. In this respect the proposals of Sechenov are helpful for medical science in the twenty-first century too but nearly unknown.     

Walter Rudolf Hess (1881-1973) and his contribution to neuroscience

The present account includes a brief life history of Walter Rudolf Hess (1881-1973) and a review of his major neurophysiological contributions. Hess belonged to the nearly extinct generation of great universalists among students of human physiology. He began his scientific work in hemodynamics and ophthalmology, then studied the functional organization and regulation of circulation and respiration and developed a number of highly sophisticated instruments which fostered his international reputation. By electrically stimulating the brain of the unanesthetized, freely moving animal he explored the functional organization and localization of the cat diencephalon in terms of autonomic, extrapyramidal motor functions, and instinctive behavior, e.g. hunger, thirst, fear, and rage. His thoughts on biological order led him to consider the problems of psychic forces. He was convinced of the close correlation of behavioral research and neurophysiology and believed that neuronal patterns determine the content of consciousness without providing clues concerning the transformation of such patterns into subjective experience.     

The Three Musketeers and the Twelve Cranial Nerves

The present account includes a brief life history of Walter Rudolf Hess (1881-1973) and a review of his major neurophysiological contributions. Hess belonged to the nearly extinct generation of great universalists among students of human physiology. He began his scientific work in hemodynamics and ophthalmology, then studied the functional organization and regulation of circulation and respiration and developed a number of highly sophisticated instruments which fostered his international reputation. By electrically stimulating the brain of the unanesthetized, freely moving animal he explored the functional organization and localization of the cat diencephalon in terms of autonomic, extrapyramidal motor functions, and instinctive behavior, e.g. hunger, thirst, fear, and rage. His thoughts on biological order led him to consider the problems of psychic forces. He was convinced of the close correlation of behavioral research and neurophysiology and believed that neuronal patterns determine the content of consciousness without providing clues concerning the transformation of such patterns into subjective experience.     

Hallucinations and pathological visual perceptions in Maupassant's fantastical short stories--a neurological approach

Maupassant excelled as a realist writer of the nineteenth century, with fantastical short stories being an outstanding example of his literary genius. We have analysed four of his fantastical stories from a neurological point of view. In "Le Horla," his masterpiece, we have found nightmares, sleep paralysis, a hemianopic pattern of loss and recovery of vision, and palinopsia. In "Qui sait" and in "La main" there is also an illusory movement of the objects in the visual field, although in a dreamlike complex pattern. In "Lui," autoscopy and hypnagogic hallucinations emerge as fantastical key elements. The writer suffered from severe migraine and neurosyphilis involving the optic nerve, which led to his death by general paralysis of the insane (GPI). Visual loss and visual hallucinations affected the author in his last years, before a delirant state confined him to a nursing home. Our original hypothesis, which stated that he could have translated his sensorial experiences coming from this source to his works, had to be revised by analyzing some of his earliest works, notably "Le Docteur Héraclius Gloss" and "La main d'écorché" (1875). We found hallucinatory symptoms, adopting the form of autoscopy and other elaborated visual misperceptions, in stories written at age 25, when Maupassant was allegedly healthy. Therefore, we hypothesize that they may be related to his hypersensitive disposition, assuming that no pathology is necessary to experience such vivid experiences. In addition, Maupassant's abuse of drugs, as illustrated in "Rêves," could have provided an additional element to outline his painstaking visual depictions. All these factors, in addition to his up-to-date neurological knowledge and attendance at Charcot's lectures at "La Salpêtrière," armed the author for repetitive and enriched hallucinatory experiences, which were transferred relentlessly into his works from the beginning of his career.     

Ivane tarkhnishvili (tarchanoff): a major georgian figure from the Russian physiological school

This article is dedicated to one of the outstanding scientists of the nineteenth century: Ivane Tarkhnishvili (Tarchanoff), a Russian physiologist of Georgian origin who graduated from the St. Petersburg Medico-Surgical Academy and worked under the supervision of the founder of Russian physiology, Ivan Sechenov. Among his numerous contributions was the discovery of the skin galvanic reflex; however, Tarkhnishvili's most significant contribution was the discovery of the influence of X-rays on the central nervous system, animal behavior, the heart and circulation, and embryonic development. Indeed, these works have given rise to a new field in science (radiobiology).     

Cerebral automatism, the brain, and the soul in Bram Stoker's Dracula

Neither literary critics nor historians of science have acknowledged the extent to which Bram Stoker's Dracula (1897) is indebted to late-Victorian neurologists, particularly David Ferrier, John Burdon-Sanderson, Thomas Huxley, and William Carpenter. Stoker came from a family of distinguished Irish physicians and obtained an M.A. in mathematics from Trinity College, Dublin. His personal library contained volumes on physiology, and his composition notes for Dracula include typewritten pages on somnambulism, trance states, and cranial injuries. Stoker used his knowledge of neurology extensively in Dracula. The automatic behaviors practiced by Dracula and his vampiric minions, such as somnambulism and hypnotic trance states, reflect theories about reflex action postulated by Ferrier and other physiologists. These scientists traced such automatic behaviors to the brain stem and suggested that human behavior was "determined" through the reflex action of the body and brain-a position that threatened to undermine entrenched beliefs in free will and the immortal soul. I suggest that Stoker's vampire protagonist dramatizes the pervasive late-nineteenth-century fear that human beings are soulless machines motivated solely by physiological factors.     

Ivane Tarkhnishvili (Tarchanoff): A Major Georgian Figure from the Russian Physiological School

This article is dedicated to one of the outstanding scientists of the nineteenth century: Ivane Tarkhnishvili (Tarchanoff), a Russian physiologist of Georgian origin who graduated from the St. Petersburg Medico-Surgical Academy and worked under the supervision of the founder of Russian physiology, Ivan Sechenov. Among his numerous contributions was the discovery of the skin galvanic reflex; however, Tarkhnishvili's most significant contribution was the discovery of the influence of X-rays on the central nervous system, animal behavior, the heart and circulation, and embryonic development. Indeed, these works have given rise to a new field in science (radiobiology).     

Darwin Wept: Science and the Sentimental Subject

Could a man of science be sentimental in an age of objectivity, when emotions were largely purged from the field of Victorian science, and feelings themselves defined as animal instincts and reflex mechanisms? This essay addresses the question through Darwin's work on the expression of emotions, and the relationship between his work and his own emotional experience, with particular attention to grief and tears. An old woman in a railway carriage is suddenly overcome with a painful recollection, perhaps that of a long lost child – her mouth becomes ever so slightly contracted, her countenance falls, her eyes suffuse with tears … . An opthalmic surgeon perseveres with his treatise on the physiology of weeping while mourning the loss of his daughter … . With difficulty, a mother prolongs her infant son's screaming in order to record the shape of his mouth for a family friend and famous naturalist … . Her observations later appear in a work on emotional expression (Darwin's), together with photographs of sobbing children, and faces of a psychiatric patient charged with electrodes. Such subject matter, presented in correspondence, private journals, and print, suggest that science and sentimentality could form a more reciprocal pair, where observation was conducted in a sentimental setting, the feelings of observers regulated but not withheld, processed by an experimental regime, and then reinserted in the domain of print, reconfiguring the sentimental for Victorian readers.