Beyond descriptive neurology: Broca,cerebral hemodynamics,and cortical function

Pierre-Paul Broca’s studies in neurobiology remain of interest. I review a previously neglected aspect of Broca’s work in which he presages the use of modern scanning techniques. Broca’s goal was to correlate cerebral metabolism to regional cerebral blood flow (CBF) using a novel method, to which he referred as cerebral thermometry. Broca attempted to measure changes in temperatures from the ischemic area and across the watershed regions during a stroke, and the increased CBF produced by performing a cognitive task such as reading aloud. The method involved measurements of local temperatures at specific points about the head with an array of strategically placed thermometers much as EEG electrodes are arrayed to record the electrical activity of the brain. Although his technique was inaccurate and unreliable, the concept of measuring CBF as a diagnostic aid and as a cognitive research tool was prescient. Broca’s limitation was not conceptual but purely technological. Broca’s attempt to measure CBF as a surrogate for cerebral metabolism was conceptually valid but premature because he lacked the technology necessary to do so.     

The White Paper: Wilder Penfield,the Stream of Consciousness,and the Physiology of Mind

ABSTRACT

Wilder Penfield is justly famous for his contributions to our understanding of epilepsy and of the structure-function relationship of the brain. His theory on the relationship of the brain and mind is less well known. Based on the effects of the electrical stimulation of the cortex in conscious patients, Penfield believed that consciousness and mind are functions of what he referred to as the centrencephalic integrating system. This functional system comprised bidirectional pathways between the upper brainstem, the thalami, and the cerebral cortex of both hemispheres, and was the physical substrate from which memory, perception, initiative, will, and judgment arose. It was the source of the stream of consciousness and the physical basis of mind. This paper reviews how Penfield arrived at this conception of the mind-brain relationship. Although Penfield ultimately felt that he had failed in his attempt to unify brain and mind, his work shed new light on the relationship of memory to the mesial temporal structures and to the temporal cortex; and his association of consciousness and the brainstem preceded the conceptualization of the reticular activating system by a generation. In these, as in so many aspects of neurobiology, Penfield was prescient.     

Ludwig Heinrich Bojanus (1776–1827) on Gall’s craniognomic system,zoology, and comparative anatomy

ABSTRACT

Most of what was known about Franz Joseph Gall’s (1758–1828) organology or Schädellehre prior to the 1820s came from secondary sources, including letters from correspondents, promotional materials, brief newspaper articles about his lecture-demonstrations, and editions and translations of some lengthier works of varying quality in German. Physician Ludwig Heinrich Bojanus (1776–1827) practiced in Vienna’s General Hospital in 1797–1798; attended some of Gall’s public lectures; and, in 1801–1802, became one of the first physicians to provide detailed reports on Gall’s emerging organology in French and English, respectively. Although Bojanus considered the human mind to be indivisible and did not entirely agree with Gall’s assumption that the brain consists of a number of independent organs responsible for various faculties, he provided valuable information and thoughtful commentary on Gall’s views. Furthermore, he defended Gall against the charge that his sort of thinking would lead to materialism and cautiously predicted that the new system would be fruitful for developing and stimulating important new research about the brain and mind. Bojanus became a professor of zoology in 1806 and a professor of comparative anatomy in 1814 at Vilnius University, where, among other accomplishments, he established himself as a founder of modern veterinary medicine and a pioneer of pre-Darwinian and pre-Lamarckian evolutionism.     

Brain, mind, and body: interactions with art in renaissance Italy

The Renaissance saw the first systematic anatomical and physiological studies of the brain and human body because scientists, for the first time in centuries, were allowed to dissect human bodies for study. Renaissance artists were frequently found at dissections and their attention to detail can be observed in their products. Scientists themselves were increasingly artistic, and they created astonishing anatomical models and illustrations that can still be studied. The cross-fertilization of art and science in the Renaissance resulted in more scientific analyses of neuroanatomy as well as more creative ways in which such analyses could be depicted. Both art and science benefited from the reciprocal ways in which the two influenced each other even as they provided new ways of explaining the mysteries of the human body and mind.     

The Art of Taphonomy and the Taphonomy of Art: Layer IV,Molodova I,Ukraine

Level IV of Molodova I, an open-air Middle Paleolithic site in the Ukraine has been described by some researchers as a possible source of evidence for early symbolic behavior. We examined bone objects from this layer that were identified by Ukrainian researchers as exhibiting possible Neandertal produced engravings including two anthropomorphic figures. While we have determined that there is no evidence of symbolic activity at Molodova I, the database we have created, with its systematic recording of traces left by taphonomic agents on faunal remains, provides a better understanding of the overall site taphonomy.     

Captivating thoughts: nocturnal pollution,imagination and the sleeping mind in the twelfth and thirteenth centuries

ABSTRACT

Medieval attempts to understand nocturnal emissions – involuntary bodily excretions during sleep which were identified as morally ambiguous – became extensive explorations of the unique and problematic features of sleep and the mental state it produced. During the twelfth and thirteenth centuries, nocturnal pollutions became the object of an intensive scrutiny of sleep as a site of moral concern. Causal explanations often centred on human psychology, in particular the unusual status of the sleeping mind, in an attempt to understand the intricate ways in which mind, body and soul were uniquely bound together in sleep. The mental states before, during and after sleep were understood to interact with one another in complex ways which centred on questions of culpability and its lack. A comparison of medical, natural-philosophical, theological and canon law materials discussing nocturnal pollution reveals a preoccupation with the sleeper’s mind as exceptional, uncontrollable and problematic.     

集体良知：个人与社会自然的联结纽带——涂尔干的核心问题及其研究进路之二

埃米尔.涂尔干在其研究生涯中,构筑了以人性和社会自然的心物二重性为基础与核心的社会学思想,并进一步阐述了社会与人性自然之间的联结纽带——社会良知、知识分子是社会良知的担当者与表达者以及社会良知应该以神圣化的仪式和仪轨表达出来才能成为真正的集体规范、社会事实。由此,涂尔干通过＂心物二元＂的研究路径构建了＂精神＂与＂躯体＂、＂个人＂与＂社会＂二者都不偏废的二元研究范式,其目的就是要解决社会发展最为核心的问题——人性与社会的自然及社会秩序何以可能的问题。     

From brain to neuro: the brain research association and the making of British neuroscience, 1965-1996

This article explores the short history of "neuroscience" as a discipline in its own right as opposed to the much longer past of the brain sciences. It focuses on one historical moment, the formation of the first British "neuroscience" society, the Brain Research Association (BRA), renamed in 1996 to the British Neuroscience Association (BNA). It outlines the new thinking brought about by this new science of brain, mind, and behavior, it sketches the beginnings of the BRA and the institutionalization of neuroscience in the British context, and it further explores the ambiguous relation the association had towards some of the ethical, social, and political implications of this new area of research.     

历史语境、史学语境与史料的解读——以弗吉尼亚州批准美国宪法大会中一条材料的解读为例

"语境主义"意识对于历史研究具有重要的意义。历史学家在解读具体的史料时,只有清楚而准确地把握史料产生的"历史语境",以及由相关研究构成的"史学语境",才有可能探明史料的"原意",进而恰当地运用史料。     

Alcmaeon of Croton's Observations on Health, Brain, Mind, and Soul

Alcmaeon of Croton (sixth-fifth century BC), a pre-Socratic physician-philosopher, introduced the concept that mind and soul are located in the brain. Alcmaeon made observations about seeing, hearing, tasting, and smelling and distinguished perception from understanding. Alcmaeon contributed two major ideas to natural sciences: (1) the brain is the seat of human intelligence, and (2) physicians should draw conclusions from empirical observations, an idea that implicitly rejects the alternative notion that science should depend on "divine revelation." Two thousand and five-hundred years later, these two insights remain true and guarantee Alcmaeon a place in the history of neuroscience.     

The Moscow Colloquium on Electroencephalography of Higher Nervous Activity and its impact on international brain research

Late 1950s was a period of recognition of Russian neurophysiology by international neuroscience community and vice versa. This process of "opening windows in both directions" might be illustrated by the story of The Moscow Colloquium on Electroencephalography of Higher Nervous Activity. The Colloquium took place on October 6-11, 1958 at the House of Scientists in Moscow. It was organized by the Academy of Sciences of the USSR under the initiative of the Institute for Higher Nervous Activity and focused on (a) EEG correlates of cortical excitation and inhibition; (b) electrophysiological study of different brain structures and their role in conditioned reflexes; and (c) EEG of higher nervous activity in humans. At the final session it was suggested to launch an International Year for the Study of the Brain and to ask UNESCO for international coordination of brain research. This resulted into the International Brain Research Organization (IBRO) founded in 1960. This article is based on unpublished records of international contacts of Soviet neurophysiologists and organization of the Moscow Colloquium from the Archive of Russian Academy of Science (ARAN), reports in Soviet periodicals, publications in obscure Festschriften, etc.     

Alcmaeon of Croton's Observations on Health,Brain, Mind,and Soul

Alcmaeon of Croton (sixth–fifth century BC), a pre-Socratic physician–philosopher, introduced the concept that mind and soul are located in the brain. Alcmaeon made observations about seeing, hearing, tasting, and smelling and distinguished perception from understanding. Alcmaeon contributed two major ideas to natural sciences: (1) the brain is the seat of human intelligence, and (2) physicians should draw conclusions from empirical observations, an idea that implicitly rejects the alternative notion that science should depend on “divine revelation.” Two thousand and five-hundred years later, these two insights remain true and guarantee Alcmaeon a place in the history of neuroscience.     

Representation and identity ‐ convergence of brain research and mind‐brain philosophy

Abstract

The localization or representation of mental abilities in the brain have always been considered as key questions for understanding the organization of the human nervous system. Particularly with the advent of modern electrophysiological and imaging techniques that provide maps of electromagnetic fields and metabolic processes on the living central nervous system, the representation theory is experiencing a scientific renaissance in neurology, but is only one theory, however, in the succession of a long philosophical tradition dealing with the possible identification of mental phenomena and brain processes. This dichotomy was formulated at the latest in the Cartesian dualism of res cogitans and res extensa of the mind‐body problem. Nowadays philosophical discussion, on the contrary, is dominated by monistic concepts that attempt to explain the mental realm on an organic foundation in order not to succumb to the problem of a psychophysical dualism. Of these, the identity theory offers a philosophically plausible concept postulating that the identity of brain conditions and mental phenomena is based on organic foundations. In this theory, the efforts of brain research converge on the representations of mental phenomena in the human nervous system. In a comprehensive approach, both concepts could complement each other.     

The search for a precise method of measurement in psychical experiments

Presents three brief case studies to show how cognition and psychic activity were explored as energetic and economic transactions in a variety of experimental settings. First, in the 1870's German psychiatrist Emil Kraepelin began a search for an objective measurement of cognitive performance in which he engaged for several decades. His investigations resulted in a graphic representation of cognitive efficiency, the Arbeitscurve, delineating numbers of additions per time interval in close resemblance to representations of machine efficiency. Second, at the turn of the century American nutrition scientist and agronomist Wilbur Olin Atwater convinced himself in a series of precision measurements that the human motor was a perfectly closed input-output system and that any mental surplus in the form of cognitive energy transformation did not count as contradictions to the principle of the conservation of energy. Third, at the beginning of the 20th century and on the basis of Atwater's results, German psychiatrist Hans Berger stipulated a special form of psychic energy for mediating between the principle of the conservation of energy and mental causality. Berger attempted to quantify psychic energy as one factor of brain metabolism. In the three cases of precision investigations into psychic life presented here, the experimental space of psychophysiology turned mental activity into a form of machine-like behavior.     

The Moscow Colloquium on Electroencephalography of Higher Nervous Activity and Its Impact on International Brain Research

Late 1950s was a period of recognition of Russian neurophysiology by international neuroscience community and vice versa. This process of “opening windows in both directions” might be illustrated by the story of The Moscow Colloquium on Electroencephalography of Higher Nervous Activity.

The Colloquium took place on October 6–11, 1958 at the House of Scientists in Moscow. It was organized by the Academy of Sciences of the USSR under the initiative of the Institute for Higher Nervous Activity and focused on (a) EEG correlates of cortical excitation and inhibition; (b) electrophysiological study of different brain structures and their role in conditioned reflexes; and (c) EEG of higher nervous activity in humans.

At the final session it was suggested to launch an International Year for the Study of the Brain and to ask UNESCO for international coordination of brain research. This resulted into the International Brain Research Organization (IBRO) founded in 1960.

This article is based on unpublished records of international contacts of Soviet neurophysiologists and organization of the Moscow Colloquium from the Archive of Russian Academy of Science (ARAN), reports in Soviet periodicals, publications in obscure Festschriften, etc.     

Historical development of the dopamine hypothesis of schizophrenia

This review examines the history of discoveries that contributed to development of the dopamine hypothesis of schizophrenia. The origin of the hypothesis is traced to the recognition that neuroleptic drugs interfere with brain dopamine function. This insight was derived from two distinct lines of research. The first line originated from the discovery in 1956 that reserpine depletes brain serotonin. This finding resulted in a sequence of studies that led to the discovery that brain dopamine is involved in neuroleptic-induced extrapyramidal motor disturbances. The second line of research was aimed at determining the mechanism of action of psychomotor stimulants. This research produced evidence that stimulants directly or indirectly activate brain dopamine receptors. Because nonreserpine neuroleptics such as chlorpromazine block stimulant-induced movement, these findings suggested that neuroleptics were dopamine antagonists. Most previous accounts of the development of the dopamine hypothesis of schizophrenia emphasize the first line of research and ignore the second.     

Historical Development of the Dopamine Hypothesis of Schizophrenia

This review examines the history of discoveries that contributed to development of the dopamine hypothesis of schizophrenia. The origin of the hypothesis is traced to the recognition that neuroleptic drugs interfere with brain dopamine function. This insight was derived from two distinct lines of research. The first line originated from the discovery in 1956 that reserpine depletes brain serotonin. This finding resulted in a sequence of studies that led to the discovery that brain dopamine is involved in neuroleptic-induced extrapyramidal motor disturbances. The second line of research was aimed at determining the mechanism of action of psychomotor stimulants. This research produced evidence that stimulants directly or indirectly activate brain dopamine receptors. Because nonreserpine neuroleptics such as chlorpromazine block stimulant-induced movement, these findings suggested that neuroleptics were dopamine antagonists. Most previous accounts of the development of the dopamine hypothesis of schizophrenia emphasize the first line of research and ignore the second.     

Adaptation and foraging from the Terminal Pleistocene to the Early Holocene: Excavation at Bubog on Ilin Island,Philippines

Abstract

The recently discovered human remains from Callao Cave, northern Luzon, Philippines securely date the migration of hominins into the Philippines to ca. 70 kya (thousands of years ago). The direct route to reach Luzon from the Asian mainland is via Borneo, Palawan, through Mindoro and into Luzon. Our research focuses on Mindoro Island as a potential stepping stone to the main Philippine Archipelago. While Palawan and Luzon have produced evidence for early human occupation, no systematic research on the prehistory of Mindoro has been conducted until now. We report on recent archaeological investigations at the Bubog rockshelter sites on the small island of Ilin just off the coast of Mindoro. The excavations produced evidence of stratified sequences of human habitation at the two rockshelter sites in the form of dense shell middens that date to ca. 11 kya onwards. They provide direct evidence on how variability in landscape formation, sea levels, and landmass during the terminal Pleistocene and early Holocene influenced the behavior of early human populations. Numerous species of molluscs were recorded and provisional results indicate variations in the invertebrate faunas throughout the stratigraphic sequences, resulting from sea level rise and the establishment of coral reefs between Ilin and Mindoro at the end of the Pleistocene. Our results contribute substantially to our understanding of the processes of human island adaptation, complement ongoing research into Island Southeast Asia’s paleogeography, and enhance current knowledge of prehistoric subsistence strategies across the region.     

A Concert Hall for Stringed Musical Instruments Under the Splenium of the Corpus Callosum

This article contains an account of the career of John Eccles that can be divided into two parts. The first extends from 1925, when he won a Rhodes scholarship to Magdalen College Oxford, to 1975, when he took voluntary retirement from the State University of New York at Buffalo. During this period, he set up six different laboratories in which he carried out research on synaptic mechanisms that provide the basis of neuroscience. The second period is the 20 years between his retirement and death in Switzerland, which he spent on the problem of the relationship between mind and brain.